Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the vancomycin level is 30 mg/L. The half-life is 6 h, and the drug is eliminated by first-order kinetics. What is the level C 1 h later?
Practice exercise (made-up values, not clinical guidance). A patient who weighs 84 kg needs a loading dose of tobramycin to reach a level of 6 mg/L straight away. The volume of distribution is 0.3 L/kg. Find the loading dose LD in mg.
Practice exercise (made-up values, not clinical guidance). Vancomycin is given as a continuous infusion to a patient whose vancomycin clearance is 110 mL/min. What infusion rate R in mg/h gives a steady-state level of 25 mg/L?
Practice exercise (made-up values, not clinical guidance). A patient receives an IV bolus of 150 mg of gentamicin. The level back-extrapolated to time zero is 6 mg/L and the half-life is 2.5 h. Find the clearance CL in L/h.
Practice exercise (made-up values, not clinical guidance). A patient receives vancomycin IV every 12 h; the vancomycin clearance is 4.5 L/h. What dose D in mg gives an average steady-state level of 25 mg/L?
Practice exercise (made-up values, not clinical guidance). A vancomycin infusion runs at 80 mg/h with no loading dose. The patient's clearance is 4 L/h and the half-life is 8 h. What is the level C after 11 h?
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