Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the gentamicin level is 7 mg/L. The half-life is 3 h, and the drug is eliminated by first-order kinetics. What is the level C 3 h later?
Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the gentamicin level is 6 mg/L. The half-life is 2 h, and the drug is eliminated by first-order kinetics. What is the level C 6 h later?
Practice exercise (made-up values, not clinical guidance). A 51 kg patient is to be loaded intravenously with phenytoin sodium to reach a phenytoin level of 15 mg/L. The volume of distribution is 0.7 L/kg and the salt factor is S = 0.92. Find the loading dose LD of phenytoin sodium in mg.
Practice exercise (made-up values, not clinical guidance). A patient receives an IV bolus of 120 mg of tobramycin. The level back-extrapolated to time zero is 8 mg/L and the half-life is 2.5 h. Find the clearance CL in L/h.
Practice exercise (made-up values, not clinical guidance). A 68-year-old man weighs 80 kg and has a serum creatinine of 1.6 mg/dL (141 µmol/L). Estimate the creatinine clearance with Cockcroft–Gault: CrCl (mL/min) = (140 − age) × weight (kg)/(72 × SCr in mg/dL), × 0.85 for women. The usual cefazolin dose is 1000 mg every 8 h for a creatinine clearance of 100 mL/min. Keeping the interval, the dose is reduced in proportion to the creatinine clearance. Find the adjusted dose D. Round to the nearest whole number.
Practice exercise (made-up values, not clinical guidance). A 99 kg patient takes oral aminophylline (S = 0.8, F = 1) every 8 h. The theophylline clearance is 0.035 L/kg/h. What dose D in mg gives an average steady-state level of 15 mg/L?
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