Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the vancomycin level is 40 mg/L. The half-life is 8 h, and the drug is eliminated by first-order kinetics. What is the level C 11 h later?
Practice exercise (made-up values, not clinical guidance). A patient receives aminophylline as a constant IV infusion without a loading dose. The half-life is 6 h. What percentage f of the steady-state level has been reached after 21 h?
Practice exercise (made-up values, not clinical guidance). A 60 kg patient receives a theophylline infusion. The clearance is 0.035 L/kg/h. What infusion rate R in mg/h gives a steady-state level of 15 mg/L?
Practice exercise (made-up values, not clinical guidance). A 66 kg patient is to receive an aminophylline infusion (salt factor S = 0.8: 80% of aminophylline is theophylline). The theophylline clearance is 0.035 L/kg/h. What aminophylline infusion rate R in mg/h gives a steady-state theophylline level of 15 mg/L?
Practice exercise (made-up values, not clinical guidance). A 100 kg patient takes oral theophylline (F = 1) every 8 h. The clearance is 0.045 L/kg/h. What dose D in mg gives an average steady-state level of 10 mg/L?
Practice exercise (made-up values, not clinical guidance). A theophylline infusion runs at 52.5 mg/h with no loading dose. The patient's clearance is 3.5 L/h and the half-life is 6 h. What is the level C after 4 h?
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