Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the tobramycin level is 8 mg/L. The half-life is 2.5 h, and the drug is eliminated by first-order kinetics. What is the level C 7.5 h later?
Practice exercise (made-up values, not clinical guidance). A patient who weighs 80 kg needs a loading dose of vancomycin to reach a level of 30 mg/L straight away. The volume of distribution is 0.7 L/kg. Find the loading dose LD in mg.
Practice exercise (made-up values, not clinical guidance). A 92 kg patient receives a theophylline infusion. The clearance is 0.035 L/kg/h. What infusion rate R in mg/h gives a steady-state level of 10 mg/L?
Practice exercise (made-up values, not clinical guidance). After an IV dose of tobramycin, the level is 6 mg/L at 2 h and 2.4 mg/L at 6 h. Assume first-order elimination. Find the elimination rate constant k.
Practice exercise (made-up values, not clinical guidance). An 85 kg patient has a phenytoin level of 10 mg/L; the target is 20 mg/L. The drug is given intravenously as phenytoin sodium (S = 0.92), and the volume of distribution is 0.7 L/kg. What extra loading dose LD raises the level to the target?
Practice exercise (made-up values, not clinical guidance). An 80 kg patient takes oral aminophylline (S = 0.8, F = 1) every 12 h. The theophylline clearance is 0.04 L/kg/h. What dose D in mg gives an average steady-state level of 12 mg/L?
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