Practice exercise (made-up values, not clinical guidance). A patient who weighs 75 kg needs a loading dose of gentamicin to reach a level of 10 mg/L straight away. The volume of distribution is 0.25 L/kg. Find the loading dose LD in mg.
Practice exercise (made-up values, not clinical guidance). A patient who weighs 62 kg needs a loading dose of gentamicin to reach a level of 6 mg/L straight away. The volume of distribution is 0.25 L/kg. Find the loading dose LD in mg.
Practice exercise (made-up values, not clinical guidance). Vancomycin is given as a continuous infusion to a patient whose vancomycin clearance is 50 mL/min. What infusion rate R in mg/h gives a steady-state level of 25 mg/L?
Practice exercise (made-up values, not clinical guidance). An 83 kg patient receives a theophylline infusion. The clearance is 0.03 L/kg/h. What infusion rate R in mg/h gives a steady-state level of 15 mg/L?
Practice exercise (made-up values, not clinical guidance). An 87 kg patient takes oral theophylline (F = 1) every 12 h. The clearance is 0.045 L/kg/h. Each dose is 300 mg of theophylline. Find the average steady-state level Css,avg.
Practice exercise (made-up values, not clinical guidance). A 76 kg patient on regular gentamicin doses is at steady state. The target is a peak of 7 mg/L and a trough of 0.5 mg/L, and the volume of distribution is 0.3 L/kg. Assuming rapid IV doses, what dose D raises the level from the trough to the peak?
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