Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the tobramycin level is 10 mg/L. The half-life is 3 h, and the drug is eliminated by first-order kinetics. What is the level C 4 h later?
Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the vancomycin level is 35 mg/L. The half-life is 9 h, and the drug is eliminated by first-order kinetics. What is the level C 2 h later?
Practice exercise (made-up values, not clinical guidance). A 50 kg patient is to be loaded with digoxin tablets to reach a level of 1 mcg/L. The volume of distribution is 7 L/kg and the tablets have a bioavailability F = 0.7. Find the total oral loading dose LD in mcg.
Practice exercise (made-up values, not clinical guidance). A 99 kg patient is to be loaded with digoxin tablets to reach a level of 1 mcg/L. The volume of distribution is 7 L/kg and the tablets have a bioavailability F = 0.7. Find the total oral loading dose LD in mcg.
Practice exercise (made-up values, not clinical guidance). A theophylline infusion runs at 42 mg/h with no loading dose. The patient's clearance is 3.5 L/h and the half-life is 9 h. What is the level C after 23 h?
Practice exercise (made-up values, not clinical guidance). A vancomycin infusion runs at 125 mg/h with no loading dose. The patient's clearance is 5 L/h and the half-life is 8 h. What is the level C after 9 h?
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