Practice exercise (made-up values, not clinical guidance). A patient who weighs 93 kg needs a loading dose of vancomycin to reach a level of 20 mg/L straight away. The volume of distribution is 0.7 L/kg. Find the loading dose LD in mg.
Practice exercise (made-up values, not clinical guidance). In a patient, vancomycin has an elimination half-life of 9 h. Find the elimination rate constant k in h⁻¹.
Practice exercise (made-up values, not clinical guidance). After an IV dose of tobramycin, the level is 8 mg/L at 1 h and 3.2 mg/L at 5 h. Assume first-order elimination. Find the half-life t½.
Practice exercise (made-up values, not clinical guidance). A patient receives an IV bolus of 210 mg of tobramycin. The level back-extrapolated to time zero is 7 mg/L and the half-life is 3 h. Find the clearance CL in L/h.
Practice exercise (made-up values, not clinical guidance). A 66 kg patient has a phenytoin level of 8 mg/L; the target is 20 mg/L. The drug is given intravenously as phenytoin sodium (S = 0.92), and the volume of distribution is 0.7 L/kg. What extra loading dose LD raises the level to the target?
Practice exercise (made-up values, not clinical guidance). A vancomycin infusion runs at 100 mg/h with no loading dose. The patient's clearance is 5 L/h and the half-life is 6 h. What is the level C after 10 h?
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