Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the tobramycin level is 6 mg/L. The half-life is 2 h, and the drug is eliminated by first-order kinetics. What is the level C 2 h later?
Practice exercise (made-up values, not clinical guidance). A patient who weighs 108 kg needs a loading dose of tobramycin to reach a level of 8 mg/L straight away. The volume of distribution is 0.3 L/kg. Find the loading dose LD in mg.
Practice exercise (made-up values, not clinical guidance). A patient receives an IV bolus of 110 mg of tobramycin. The level back-extrapolated to time zero is 8 mg/L and the half-life is 2 h. Find the clearance CL in L/h.
Practice exercise (made-up values, not clinical guidance). A patient has a lidocaine clearance of 600 mL/min. What infusion rate R in mg/min keeps the steady-state level at 4 mg/L?
Practice exercise (made-up values, not clinical guidance). A 92 kg patient has a digoxin level of 0.5 mcg/L; the target is 1 mcg/L. The volume of distribution is 7 L/kg and the tablets have F = 0.7. What extra loading dose LD raises the level to the target?
Practice exercise (made-up values, not clinical guidance). A theophylline infusion runs at 42 mg/h with no loading dose. The patient's clearance is 3.5 L/h and the half-life is 9 h. What is the level C after 2 h?
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