Practice exercise (made-up values, not clinical guidance). A patient who weighs 64 kg needs a loading dose of gentamicin to reach a level of 6 mg/L straight away. The volume of distribution is 0.25 L/kg. Find the loading dose LD in mg.
Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the tobramycin level is 6 mg/L. The half-life is 2 h, and the drug is eliminated by first-order kinetics. What is the level C 3 h later?
Practice exercise (made-up values, not clinical guidance). After an IV dose of gentamicin, the level is 8 mg/L at 2 h and 3.5 mg/L at 5 h. Assume first-order elimination. Find the elimination rate constant k.
Practice exercise (made-up values, not clinical guidance). A 55 kg patient is to be loaded with digoxin tablets to reach a level of 0.8 mcg/L. The volume of distribution is 7 L/kg and the tablets have a bioavailability F = 0.7. Find the total oral loading dose LD in mcg.
Practice exercise (made-up values, not clinical guidance). An 81 kg patient has a theophylline level of 6 mg/L; the target is 12 mg/L. The drug is given intravenously as aminophylline (S = 0.8), and the volume of distribution is 0.5 L/kg. What extra loading dose LD raises the level to the target?
Practice exercise (made-up values, not clinical guidance). A 66 kg patient on regular gentamicin doses is at steady state. The target is a peak of 6 mg/L and a trough of 0.5 mg/L, and the volume of distribution is 0.3 L/kg. Assuming rapid IV doses, what dose D raises the level from the trough to the peak?
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