Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the vancomycin level is 30 mg/L. The half-life is 10 h, and the drug is eliminated by first-order kinetics. What is the level C 20 h later?
Practice exercise (made-up values, not clinical guidance). The elimination rate constant of lidocaine in a patient is 0.347 h⁻¹. Find the half-life t½.
Practice exercise (made-up values, not clinical guidance). A 90 kg patient is to be loaded intravenously with phenytoin sodium to reach a phenytoin level of 15 mg/L. The volume of distribution is 0.7 L/kg and the salt factor is S = 0.92. Find the loading dose LD of phenytoin sodium in mg.
Practice exercise (made-up values, not clinical guidance). A patient receives an IV bolus of 150 mg of gentamicin. The level back-extrapolated to time zero is 8 mg/L and the half-life is 3.5 h. Find the clearance CL in L/h.
Practice exercise (made-up values, not clinical guidance). A patient's gentamicin half-life is 2 h. The target is a peak of 7 mg/L and a trough of 0.5 mg/L. Assuming rapid IV doses and first-order elimination, what dosing interval τ lets the level fall from the peak to the trough? Round to one decimal place.
Practice exercise (made-up values, not clinical guidance). A vancomycin infusion is started without a loading dose. The half-life in this patient is 10 h. How long t does it take to reach 75% of the steady-state level?
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