Practice exercise (made-up values, not clinical guidance). A patient who weighs 63 kg needs a loading dose of theophylline to reach a level of 15 mg/L straight away. The volume of distribution is 0.5 L/kg. Find the loading dose LD in mg.
Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the vancomycin level is 40 mg/L. The half-life is 10 h, and the drug is eliminated by first-order kinetics. What is the level C 30 h later?
Practice exercise (made-up values, not clinical guidance). After an IV dose of vancomycin, the level is 25 mg/L at 1 h and 8.8 mg/L at 13 h. Assume first-order elimination. Find the half-life t½.
Practice exercise (made-up values, not clinical guidance). An 88 kg patient is to be loaded intravenously with phenytoin sodium to reach a phenytoin level of 20 mg/L. The volume of distribution is 0.7 L/kg and the salt factor is S = 0.92. Find the loading dose LD of phenytoin sodium in mg.
Practice exercise (made-up values, not clinical guidance). A vancomycin infusion runs at 125 mg/h with no loading dose. The patient's clearance is 5 L/h and the half-life is 8 h. What is the level C after 23 h?
Practice exercise (made-up values, not clinical guidance). A patient receives vancomycin IV every 12 h; the vancomycin clearance is 5 L/h. What dose D in mg gives an average steady-state level of 20 mg/L?
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