Practice exercise (made-up values, not clinical guidance). A patient receives aminophylline as a constant IV infusion without a loading dose. The half-life is 9 h. What percentage f of the steady-state level has been reached after 13.5 h?
Practice exercise (made-up values, not clinical guidance). A patient who weighs 91 kg needs a loading dose of gentamicin to reach a level of 10 mg/L straight away. The volume of distribution is 0.25 L/kg. Find the loading dose LD in mg.
Practice exercise (made-up values, not clinical guidance). A patient receives an IV bolus of 160 mg of gentamicin. The level back-extrapolated to time zero is 6 mg/L and the half-life is 2.5 h. Find the volume of distribution Vd.
Practice exercise (made-up values, not clinical guidance). A patient receives an IV bolus of 130 mg of tobramycin. The level back-extrapolated to time zero is 7 mg/L and the half-life is 2 h. Find the clearance CL in L/h.
Practice exercise (made-up values, not clinical guidance). A vancomycin infusion runs at 75 mg/h with no loading dose. The patient's clearance is 3 L/h and the half-life is 6 h. What is the level C after 7 h?
Practice exercise (made-up values, not clinical guidance). A patient's gentamicin half-life is 4 h. The target is a peak of 6 mg/L and a trough of 0.5 mg/L. Assuming rapid IV doses and first-order elimination, what dosing interval τ lets the level fall from the peak to the trough? Round to one decimal place.
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