Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the vancomycin level is 30 mg/L. The half-life is 10 h, and the drug is eliminated by first-order kinetics. What is the level C 33 h later?
Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the tobramycin level is 10 mg/L. The half-life is 2.5 h, and the drug is eliminated by first-order kinetics. What is the level C 2.5 h later?
Practice exercise (made-up values, not clinical guidance). Vancomycin is given as a continuous infusion to a patient whose vancomycin clearance is 80 mL/min. What infusion rate R in mg/h gives a steady-state level of 20 mg/L?
Practice exercise (made-up values, not clinical guidance). A 56 kg patient is to be loaded intravenously with aminophylline to reach a theophylline level of 12 mg/L. The volume of distribution is 0.5 L/kg and the salt factor is S = 0.8. Find the loading dose LD of aminophylline in mg.
Practice exercise (made-up values, not clinical guidance). A 77 kg patient has a theophylline level of 5 mg/L; the target is 10 mg/L. The drug is given intravenously as aminophylline (S = 0.8), and the volume of distribution is 0.5 L/kg. What extra loading dose LD raises the level to the target?
Practice exercise (made-up values, not clinical guidance). An 88 kg patient takes oral theophylline (F = 1) every 8 h. The clearance is 0.045 L/kg/h. Each dose is 450 mg of theophylline. Find the average steady-state level Css,avg.
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