Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the vancomycin level is 40 mg/L. The half-life is 6 h, and the drug is eliminated by first-order kinetics. What is the level C 1 h later?
Practice exercise (made-up values, not clinical guidance). A patient who weighs 96 kg needs a loading dose of gentamicin to reach a level of 8 mg/L straight away. The volume of distribution is 0.25 L/kg. Find the loading dose LD in mg.
Practice exercise (made-up values, not clinical guidance). After an IV dose of gentamicin, the level is 8 mg/L at 2 h and 3 mg/L at 7 h. Assume first-order elimination. Find the half-life t½.
Practice exercise (made-up values, not clinical guidance). A 79 kg patient is to be loaded intravenously with phenytoin sodium to reach a phenytoin level of 20 mg/L. The volume of distribution is 0.7 L/kg and the salt factor is S = 0.92. Find the loading dose LD of phenytoin sodium in mg.
Practice exercise (made-up values, not clinical guidance). An 80 kg patient takes oral theophylline (F = 1) every 8 h. The clearance is 0.03 L/kg/h. Each dose is 300 mg of theophylline. Find the average steady-state level Css,avg.
Practice exercise (made-up values, not clinical guidance). A vancomycin infusion is started without a loading dose. The half-life in this patient is 10 h. How long t does it take to reach 95% of the steady-state level?
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