Practice exercise (made-up values, not clinical guidance). A patient receives vancomycin as a constant IV infusion without a loading dose. The half-life is 6 h. What percentage f of the steady-state level has been reached after 15 h?
Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the vancomycin level is 25 mg/L. The half-life is 7 h, and the drug is eliminated by first-order kinetics. What is the level C 23 h later?
Practice exercise (made-up values, not clinical guidance). A 53 kg patient is to be loaded with digoxin tablets to reach a level of 0.8 mcg/L. The volume of distribution is 7 L/kg and the tablets have a bioavailability F = 0.7. Find the total oral loading dose LD in mcg.
Practice exercise (made-up values, not clinical guidance). After an IV dose of tobramycin, the level is 6 mg/L at 1 h and 1.5 mg/L at 5 h. Assume first-order elimination. Find the elimination rate constant k.
Practice exercise (made-up values, not clinical guidance). A 56 kg patient has a theophylline level of 4.5 mg/L; the target is 15 mg/L. The drug is given intravenously as aminophylline (S = 0.8), and the volume of distribution is 0.5 L/kg. What extra loading dose LD raises the level to the target?
Practice exercise (made-up values, not clinical guidance). A vancomycin infusion is started without a loading dose. The half-life in this patient is 8 h. How long t does it take to reach 95% of the steady-state level?
Full step-by-step solutions: practise this topic on examproblems.com.