Practice exercise (made-up values, not clinical guidance). A patient receives lidocaine as a constant IV infusion without a loading dose. The half-life is 2 h. What percentage f of the steady-state level has been reached after 7 h?
Practice exercise (made-up values, not clinical guidance). A patient receives vancomycin as a constant IV infusion without a loading dose. The half-life is 6 h. What percentage f of the steady-state level has been reached after 21 h?
Practice exercise (made-up values, not clinical guidance). A patient receives an IV bolus of 150 mg of gentamicin. The level back-extrapolated to time zero is 6 mg/L and the half-life is 3.5 h. Find the volume of distribution Vd.
Practice exercise (made-up values, not clinical guidance). A patient has a lidocaine clearance of 900 mL/min. What infusion rate R in mg/min keeps the steady-state level at 2.5 mg/L?
Practice exercise (made-up values, not clinical guidance). A patient's tobramycin half-life is 3.5 h. The target is a peak of 8 mg/L and a trough of 0.5 mg/L. Assuming rapid IV doses and first-order elimination, what dosing interval τ lets the level fall from the peak to the trough? Round to one decimal place.
Practice exercise (made-up values, not clinical guidance). A patient receives vancomycin IV every 12 h; the vancomycin clearance is 6 L/h. Each dose is 1500 mg of vancomycin. Find the average steady-state level Css,avg.
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