Practice exercise (made-up values, not clinical guidance). A patient who weighs 81 kg needs a loading dose of gentamicin to reach a level of 8 mg/L straight away. The volume of distribution is 0.25 L/kg. Find the loading dose LD in mg.
Practice exercise (made-up values, not clinical guidance). In a patient, lidocaine has an elimination half-life of 1.5 h. Find the elimination rate constant k in h⁻¹.
Practice exercise (made-up values, not clinical guidance). A 51 kg patient is to be loaded intravenously with aminophylline to reach a theophylline level of 15 mg/L. The volume of distribution is 0.5 L/kg and the salt factor is S = 0.8. Find the loading dose LD of aminophylline in mg.
Practice exercise (made-up values, not clinical guidance). An 82 kg patient is to be loaded with digoxin tablets to reach a level of 0.8 mcg/L. The volume of distribution is 7 L/kg and the tablets have a bioavailability F = 0.7. Find the total oral loading dose LD in mcg.
Practice exercise (made-up values, not clinical guidance). A vancomycin infusion is started without a loading dose. The half-life in this patient is 8 h. How long t does it take to reach 95% of the steady-state level?
Practice exercise (made-up values, not clinical guidance). A vancomycin infusion runs at 60 mg/h with no loading dose. The patient's clearance is 3 L/h and the half-life is 10 h. What is the level C after 5 h?
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