Practice exercise (made-up values, not clinical guidance). A patient who weighs 64 kg needs a loading dose of vancomycin to reach a level of 20 mg/L straight away. The volume of distribution is 0.7 L/kg. Find the loading dose LD in mg.
Practice exercise (made-up values, not clinical guidance). A patient receives aminophylline as a constant IV infusion without a loading dose. The half-life is 9 h. What percentage f of the steady-state level has been reached after 27 h?
Practice exercise (made-up values, not clinical guidance). After an IV dose of vancomycin, the level is 35 mg/L at 1 h and 11 mg/L at 11 h. Assume first-order elimination. Find the half-life t½.
Practice exercise (made-up values, not clinical guidance). A 68 kg patient is to be loaded with digoxin tablets to reach a level of 0.8 mcg/L. The volume of distribution is 7 L/kg and the tablets have a bioavailability F = 0.7. Find the total oral loading dose LD in mcg.
Practice exercise (made-up values, not clinical guidance). A patient's gentamicin half-life is 2 h. The target is a peak of 7 mg/L and a trough of 0.5 mg/L. Assuming rapid IV doses and first-order elimination, what dosing interval τ lets the level fall from the peak to the trough? Round to one decimal place.
Practice exercise (made-up values, not clinical guidance). A theophylline infusion is started without a loading dose. The half-life in this patient is 9 h. How long t does it take to reach 90% of the steady-state level?
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