Practice exercise (made-up values, not clinical guidance). A patient who weighs 69 kg needs a loading dose of tobramycin to reach a level of 8 mg/L straight away. The volume of distribution is 0.3 L/kg. Find the loading dose LD in mg.
Practice exercise (made-up values, not clinical guidance). The elimination rate constant of vancomycin in a patient is 0.0578 h⁻¹. Find the half-life t½.
Practice exercise (made-up values, not clinical guidance). A patient receives an IV bolus of 110 mg of tobramycin. The level back-extrapolated to time zero is 6 mg/L and the half-life is 3 h. Find the volume of distribution Vd.
Practice exercise (made-up values, not clinical guidance). A patient has a lidocaine clearance of 500 mL/min. What infusion rate R in mg/min keeps the steady-state level at 4 mg/L?
Practice exercise (made-up values, not clinical guidance). A 51 kg patient on regular gentamicin doses is at steady state. The target is a peak of 7 mg/L and a trough of 1 mg/L, and the volume of distribution is 0.3 L/kg. Assuming rapid IV doses, what dose D raises the level from the trough to the peak?
Practice exercise (made-up values, not clinical guidance). A 57 kg patient on regular gentamicin doses is at steady state. The target is a peak of 10 mg/L and a trough of 1 mg/L, and the volume of distribution is 0.25 L/kg. Assuming rapid IV doses, what dose D raises the level from the trough to the peak?
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