Practice exercise (made-up values, not clinical guidance). A patient receives aminophylline as a constant IV infusion without a loading dose. The half-life is 9 h. What percentage f of the steady-state level has been reached after 13.5 h?
Practice exercise (made-up values, not clinical guidance). In a patient, theophylline has an elimination half-life of 9 h. Find the elimination rate constant k in h⁻¹.
Practice exercise (made-up values, not clinical guidance). A 64 kg patient is to be loaded intravenously with phenytoin sodium to reach a phenytoin level of 20 mg/L. The volume of distribution is 0.7 L/kg and the salt factor is S = 0.92. Find the loading dose LD of phenytoin sodium in mg.
Practice exercise (made-up values, not clinical guidance). A 99 kg patient receives a theophylline infusion. The clearance is 0.045 L/kg/h. What infusion rate R in mg/h gives a steady-state level of 15 mg/L?
Practice exercise (made-up values, not clinical guidance). An 84-year-old man weighs 89 kg and has a serum creatinine of 1.9 mg/dL (168 µmol/L). Estimate the creatinine clearance with Cockcroft–Gault: CrCl (mL/min) = (140 − age) × weight (kg)/(72 × SCr in mg/dL), × 0.85 for women. The usual levetiracetam dose is 1000 mg every 12 h for a creatinine clearance of 100 mL/min. Keeping the interval, the dose is reduced in proportion to the creatinine clearance. Find the adjusted dose D. Round to the nearest whole number.
Practice exercise (made-up values, not clinical guidance). A vancomycin infusion is started without a loading dose. The half-life in this patient is 6 h. How long t does it take to reach 50% of the steady-state level?
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