Practice exercise (made-up values, not clinical guidance). A patient who weighs 84 kg needs a loading dose of vancomycin to reach a level of 30 mg/L straight away. The volume of distribution is 0.7 L/kg. Find the loading dose LD in mg.
Practice exercise (made-up values, not clinical guidance). A patient starts regular doses of digoxin, which has a half-life of 36 h. Using the rule that steady state is reached after about five half-lives, after how many hours tss is steady state reached?
Practice exercise (made-up values, not clinical guidance). Vancomycin is given as a continuous infusion to a patient whose vancomycin clearance is 5 L/h. What infusion rate R in mg/h gives a steady-state level of 25 mg/L?
Practice exercise (made-up values, not clinical guidance). Vancomycin is given as a continuous infusion to a patient whose vancomycin clearance is 3.5 L/h. What infusion rate R in mg/h gives a steady-state level of 20 mg/L?
Practice exercise (made-up values, not clinical guidance). A patient's gentamicin half-life is 3 h. The target is a peak of 7 mg/L and a trough of 0.5 mg/L. Assuming rapid IV doses and first-order elimination, what dosing interval τ lets the level fall from the peak to the trough? Round to one decimal place.
Practice exercise (made-up values, not clinical guidance). An 83 kg patient takes oral theophylline (F = 1) every 12 h. The clearance is 0.04 L/kg/h. What dose D in mg gives an average steady-state level of 10 mg/L?
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