1.Easy
What is a typical reference range for the prothrombin time (PT) in a person not taking anticoagulants?
- AAbout 3–5 minutes
- BAbout 60–90 seconds
- CAbout 11–13.5 seconds
- DAbout 2–4 seconds
2.Easy
A raised alpha-fetoprotein (AFP) in an adult is most closely linked to which cancer?
- AProstate adenocarcinoma
- BDuctal breast cancer
- CHepatocellular (liver) cancer
- DBladder urothelial cancer
3.Easy
An older adult is found on the floor after lying there for many hours. Which blood test best shows breakdown of skeletal muscle (rhabdomyolysis)?
- ASerum albumin
- BHemoglobin A1c (HbA1c)
- CCreatine kinase (CK)
- DSerum lipase
4.Medium
A patient with a low clinical probability of deep vein thrombosis has a normal (negative) D-dimer. What is the best interpretation?
- AA DVT is unlikely and can usually be ruled out
- BThe test is useless and should always be ignored
- CA pulmonary embolism is now certain to be present
- DA DVT is confirmed and anticoagulation is needed
5.Medium
On the first day after major surgery, a patient's white cell count is 12.5 × 10³/µL, with no fever or wound signs. What is the best interpretation?
- AA laboratory error, since surgery lowers white cells
- BA sign of leukemia that needs bone marrow testing
- CA common stress response to surgery that is monitored
- DDefinite wound infection that needs antibiotics now
6.Medium
Why must a low total calcium be interpreted with care in a patient with a low serum albumin?
- AAlbumin and calcium are measured with the same chemical reaction, so they always fall together
- BMuch calcium is bound to albumin, so total calcium falls even if ionized calcium is normal
- CLow albumin makes every calcium test inaccurate and useless
- DLow albumin always causes true, symptomatic hypocalcemia
7.Hard
A patient with no kidney problems and a normal ECG has a potassium of 6.2 mEq/L. The laboratory comments that the sample was hemolyzed. What is the best interpretation?
- ATreat immediately with insulin and glucose without further checks
- BThe patient has kidney failure
- CThe potassium is certainly normal and needs no follow-up
- DThe result may be falsely high; assess the patient and arrange a repeat sample
8.Hard
A patient started methimazole for hyperthyroidism 6 weeks ago and now has a fever and a severe sore throat. Which action is most important?
- ACheck the TSH and double the dose if it is still low
- BHold the drug and arrange an urgent white cell and neutrophil count
- CAdvise the patient to continue the drug and drink more fluid
- DGive the next dose and suggest warm salt-water gargles for comfort
Answer key
- 1. C · About 11–13.5 seconds
- 2. C · Hepatocellular (liver) cancer
- 3. C · Creatine kinase (CK)
- 4. A · A DVT is unlikely and can usually be ruled out
- 5. C · A common stress response to surgery that is monitored
- 6. B · Much calcium is bound to albumin, so total calcium falls even if ionized calcium is normal
- 7. D · The result may be falsely high; assess the patient and arrange a repeat sample
- 8. B · Hold the drug and arrange an urgent white cell and neutrophil count
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