1.Easy
A raised neutrophil count (neutrophilia) is most typical of:
- AVitamin B12 deficiency
- BHay fever and asthma
- CAcute bacterial infection
- DA mild viral cold
2.Easy
Why is prealbumin (transthyretin) sometimes used to follow a patient's nutritional status instead of albumin?
- AIt has a short half-life, so it changes within days
- BIt is not affected by inflammation or liver disease
- CIt is measured in urine, so no blood test is needed
- DIt has a long half-life, so it changes over months
3.Easy
What is a typical adult reference range for total serum calcium?
- AAbout 3.5–5.0 mg/dL (0.87–1.25 mmol/L)
- BAbout 8.5–10.5 mg/dL (2.1–2.6 mmol/L)
- CAbout 12–16 mg/dL (3.0–4.0 mmol/L)
- DAbout 1.3–2.1 mg/dL (0.3–0.5 mmol/L)
4.Medium
A patient with type 2 diabetes has a target HbA1c below 7% (53 mmol/mol). Today's result is 7.8% (62 mmol/mol). What is the best interpretation?
- AThe patient has had frequent episodes of severe hypoglycemia
- BAverage glucose over the past months has been above the target
- CThe result shows today's fasting glucose is above the target
- DGlucose control has been excellent for the past several months
5.Medium
A young adult with new diabetes has a very low C-peptide level. What does this suggest?
- AThe patient has high insulin resistance, as in type 2 diabetes
- BThe kidneys are excreting all of the patient's insulin in urine
- CThe patient is injecting too much insulin and needs a lower dose
- DThe pancreas is making very little insulin, as in type 1 diabetes
6.Medium
A patient with iron-deficiency anemia started oral iron. Which result is usually the earliest sign that treatment is working?
- AA rise in the platelet count
- BA fall in the white cell count
- CA fall in the mean cell volume (MCV)
- DA rise in the reticulocyte count
7.Hard
A middle-aged man has fatigue, joint pain, a raised ALT and new diabetes. His ferritin is very high and his transferrin saturation is above 60%. Which condition is most likely?
- AHereditary hemochromatosis
- BIron-deficiency anemia
- CAnemia of chronic disease
- DAcute viral hepatitis A
8.Hard
A patient taking isoniazid for latent TB reports nausea, loss of appetite and dark urine. The ALT is five times the upper limit of normal. What is the best action?
- AContinue the isoniazid and give it with food to settle the stomach
- BDouble the dose to finish the treatment course more quickly
- CReassure the patient that dark urine is a harmless drug effect
- DHold the isoniazid and report the findings to the prescriber at once
Answer key
- 1. C · Acute bacterial infection
- 2. A · It has a short half-life, so it changes within days
- 3. B · About 8.5–10.5 mg/dL (2.1–2.6 mmol/L)
- 4. B · Average glucose over the past months has been above the target
- 5. D · The pancreas is making very little insulin, as in type 1 diabetes
- 6. D · A rise in the reticulocyte count
- 7. A · Hereditary hemochromatosis
- 8. D · Hold the isoniazid and report the findings to the prescriber at once
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