1.Easy
Why is folinic acid (leucovorin) given after high-dose methotrexate?
- ATo prevent nausea and vomiting after the methotrexate
- BTo treat an allergic reaction to methotrexate
- CTo protect normal cells from methotrexate toxicity
- DTo make methotrexate act faster on the tumour
2.Easy
Vitamin D supplements support bone health mainly by:
- AStimulating osteoclasts to break down bone
- BIncreasing calcium loss in the urine
- CIncreasing calcium absorption from the gut
- DReplacing collagen in bone
3.Easy
In hepatic encephalopathy, lactulose is given mainly to:
- ARaise the blood glucose level
- BReduce fluid in the abdomen
- CLower the blood ammonia level
- DStop bleeding from varices
4.Medium
Which type of diuretic acts on the thick ascending limb of the loop of Henle?
- AOsmotic diuretics
- BThiazide diuretics
- CLoop diuretics such as furosemide
- DPotassium-sparing diuretics
5.Medium
Which lab tests are monitored in a patient taking carbamazepine?
- AThyroid antibodies and cortisol
- BINR and aPTT
- CSerum amylase and lipase
- DFull blood count and serum sodium
6.Medium
Which side effects are most common when starting gabapentin?
- AInsomnia and agitation
- BDrowsiness and dizziness
- CHair loss and weight loss
- DCough and runny nose
7.Hard
In adult cardiac arrest with shock-refractory ventricular fibrillation, which antiarrhythmic is commonly given?
- AVerapamil
- BDigoxin
- CAdenosine
- DAmiodarone
8.Hard
A patient on simvastatin is prescribed gemfibrozil. What is the main concern?
- ALoss of all lipid-lowering effect
- BA much higher risk of myopathy and rhabdomyolysis
- CSevere hypoglycaemia
- DA sharp rise in LDL cholesterol and triglycerides
Answer key
- 1. C · To protect normal cells from methotrexate toxicity
- 2. C · Increasing calcium absorption from the gut
- 3. C · Lower the blood ammonia level
- 4. C · Loop diuretics such as furosemide
- 5. D · Full blood count and serum sodium
- 6. B · Drowsiness and dizziness
- 7. D · Amiodarone
- 8. B · A much higher risk of myopathy and rhabdomyolysis
Full step-by-step solutions: practise this topic on examproblems.com.