1.Easy
Why is folinic acid (leucovorin) given after high-dose methotrexate?
- ATo prevent nausea and vomiting after the methotrexate
- BTo make methotrexate act faster on the tumour
- CTo protect normal cells from methotrexate toxicity
- DTo treat an allergic reaction to methotrexate
2.Easy
Which class of drug is used to relieve an acute asthma attack?
- ABeta blockers
- BShort-acting beta-2 agonists
- CACE inhibitors
- DAntihistamines
3.Easy
A patient taking furosemide is advised to eat potassium-rich foods. Which food is a good choice?
- AEgg whites
- BWhite rice
- CButter
- DBananas
4.Medium
Why is ketorolac given only for a short course?
- AIt causes respiratory depression after a few days
- BIt quickly loses all its pain-relieving effect because of tolerance
- CGI bleeding and kidney injury become more likely with longer use
- DIt is a strong opioid that causes addiction
5.Medium
Macrolides such as clarithromycin act by:
- ABlocking folic acid synthesis
- BBinding the 50S ribosomal subunit to inhibit protein synthesis
- CInhibiting cell wall synthesis
- DInhibiting DNA gyrase
6.Medium
A man taking tamsulosin is planning cataract surgery. What should the nurse advise?
- ATell the eye surgeon, as it can cause floppy iris syndrome
- BTake a double dose on the day of surgery
- CStop the drug for one day and no further action is needed
- DThe drug has no link with eye surgery
7.Hard
A patient with asthma starts timolol eye drops for glaucoma and soon becomes wheezy. What is the most likely explanation?
- ATimolol activates histamine receptors in the lungs
- BThe wheeze is unrelated to the eye drops
- CTimolol is absorbed and blocks beta-2 receptors in the airways
- DThe eye drops contain an allergen that causes hay fever and asthma
8.Hard
A teenager took a large overdose of diphenhydramine. He is agitated, hot, flushed and confused, with dry skin, dilated pupils and a full bladder. What is this pattern?
- AAnticholinergic toxidrome
- BSerotonin syndrome
- COpioid toxidrome
- DCholinergic toxidrome
Answer key
- 1. C · To protect normal cells from methotrexate toxicity
- 2. B · Short-acting beta-2 agonists
- 3. D · Bananas
- 4. C · GI bleeding and kidney injury become more likely with longer use
- 5. B · Binding the 50S ribosomal subunit to inhibit protein synthesis
- 6. A · Tell the eye surgeon, as it can cause floppy iris syndrome
- 7. C · Timolol is absorbed and blocks beta-2 receptors in the airways
- 8. A · Anticholinergic toxidrome
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