1.Easy
Which adverse effect can follow long-term use of strong topical corticosteroids?
- AIncreased hair loss on the scalp
- BPermanent darkening of the nails
- CThickening of the skin
- DThinning of the skin
2.Easy
Nitrofurantoin is used mainly to treat:
- AUncomplicated cystitis (lower urinary infection)
- BBacterial meningitis in adults and children
- CBone infections
- DPneumonia
3.Easy
After chemotherapy, what is the "nadir"?
- AThe point when blood cell counts are at their lowest
- BThe time when nausea is worst
- CThe point when the tumour is at its smallest after treatment
- DThe day the drug is given
4.Medium
Which adverse effect is a well-known risk of zidovudine?
- ARed–green colour blindness
- BGum overgrowth
- COrange-red colouring of the urine and tears
- DBone marrow suppression, especially anaemia
5.Medium
Which side effect is typical of the calcium channel blocker amlodipine?
- AAnkle swelling
- BHyperkalaemia
- CDry cough
- DBronchospasm
6.Medium
A patient is starting lisinopril. Which rare but serious adverse effect should the nurse teach the patient to report immediately?
- AA harmless rash on the palms of the hands
- BSwelling of the lips, tongue or face
- CAn increase in appetite in the evening
- DDarker skin after exposure to sunlight
7.Hard
A patient who used heroin a few hours ago is given a first dose of buprenorphine and quickly develops severe withdrawal. Why?
- ABuprenorphine is a pure antagonist like naloxone with no agonist effect
- BBuprenorphine is a high-affinity partial agonist that displaces heroin
- CBuprenorphine causes an allergic reaction in heroin users
- DBuprenorphine has no effect at opioid receptors
8.Hard
Methotrexate for rheumatoid arthritis is taken once a week. A patient mistakenly takes the same dose every day. What is the main danger?
- AHypoglycaemia because methotrexate strongly stimulates insulin release
- BSevere hypertension from fluid retention
- CThe arthritis gets worse because of drug tolerance
- DBone marrow suppression and mucositis from methotrexate toxicity
Answer key
- 1. D · Thinning of the skin
- 2. A · Uncomplicated cystitis (lower urinary infection)
- 3. A · The point when blood cell counts are at their lowest
- 4. D · Bone marrow suppression, especially anaemia
- 5. A · Ankle swelling
- 6. B · Swelling of the lips, tongue or face
- 7. B · Buprenorphine is a high-affinity partial agonist that displaces heroin
- 8. D · Bone marrow suppression and mucositis from methotrexate toxicity
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