1.Easy
What is the most common side effect of first-generation antihistamines such as diphenhydramine?
- ARaised blood pressure
- BInsomnia
- CDiarrhoea
- DDrowsiness
2.Easy
Fluconazole is used to treat infections caused by:
- AFungi such as Candida
- BParasites such as malaria
- CViruses such as influenza
- DGram-negative bacteria
3.Easy
How is pernicious anaemia usually treated?
- AWith oral iron tablets for three months, then stopping
- BWith folic acid alone
- CWith vitamin B12 injections, usually for life
- DWith blood transfusions every month
4.Medium
How many micrograms are in 0.5 mg?
- A5 micrograms
- B50 micrograms
- C5000 micrograms
- D500 micrograms
5.Medium
A child weighing 20 kg is prescribed a drug at 15 mg/kg per dose. What is the dose?
- A3000 mg
- B150 mg
- C35 mg
- D300 mg
6.Medium
A patient given haloperidol develops a sudden painful twisting of the neck and the eyes roll upward. Which drug is usually given?
- AA second dose of haloperidol
- BAn anticholinergic such as benzatropine (benztropine)
- CNaloxone
- DDantrolene by mouth to relax the twisted neck muscles
7.Hard
A patient taking long-term morphine for cancer pain becomes very sedated with slow breathing. Why is naloxone given in small, diluted doses?
- ABecause naloxone is toxic to the liver in large doses
- BTo make the effect of naloxone last longer than morphine
- CBecause naloxone is much more potent and toxic in patients with cancer
- DTo restore breathing without causing severe withdrawal and pain
8.Hard
In aspirin overdose the urine may be made alkaline with sodium bicarbonate. Why does this increase salicylate excretion?
- ABicarbonate speeds up the liver metabolism of salicylate to inactive forms
- BBicarbonate binds salicylate and makes it inactive
- CMore salicylate is ionised in the tubule, so less is reabsorbed
- DAlkaline urine increases glomerular filtration
Answer key
- 1. D · Drowsiness
- 2. A · Fungi such as Candida
- 3. C · With vitamin B12 injections, usually for life
- 4. D · 500 micrograms
- 5. D · 300 mg
- 6. B · An anticholinergic such as benzatropine (benztropine)
- 7. D · To restore breathing without causing severe withdrawal and pain
- 8. C · More salicylate is ionised in the tubule, so less is reabsorbed
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