1.Easy
Sumatriptan is used mainly to:
- ARelieve nerve pain from diabetes
- BPrevent epileptic seizures
- CTreat high blood pressure
- DTreat an acute migraine attack
2.Easy
Which of these drugs has a narrow therapeutic index?
- AAmoxicillin
- BLithium
- COmeprazole
- DLoratadine
3.Easy
Which of these is a second-generation (atypical) antipsychotic?
- AHaloperidol
- BOlanzapine
- CFluphenazine
- DChlorpromazine
4.Medium
What does the clearance of a drug describe?
- AThe fraction of the dose that is absorbed
- BThe time needed for the drug to disappear completely from the plasma
- CThe volume of plasma cleared of the drug per unit of time
- DThe amount of drug removed by one dialysis session
5.Medium
Benzathine benzylpenicillin (penicillin G benzathine) is ordered. Which route is correct?
- ASubcutaneous in the abdomen
- BIntravenous push
- CIntravenous infusion over 30 minutes
- DDeep intramuscular only
6.Medium
Why do NSAIDs such as ibuprofen increase the risk of stomach ulcers?
- AThey raise the pH of gastric acid
- BThey directly dissolve the mucus layer
- CThey increase the number of Helicobacter pylori bacteria in the stomach
- DThey reduce protective prostaglandins in the stomach lining
7.Hard
A patient with severe liver cirrhosis needs a benzodiazepine for alcohol withdrawal. Why is lorazepam often chosen instead of diazepam?
- ALorazepam is a stronger anticonvulsant than all other benzodiazepines
- BLorazepam is excreted unchanged in the urine without any metabolism
- CLorazepam is cleared by simple conjugation and has no active metabolites
- DLorazepam does not cause sedation in liver disease
8.Hard
Morphine 4 mg IV is ordered. The ampoule contains 10 mg/mL. What volume should be drawn up?
- A2.5 mL
- B0.04 mL
- C0.4 mL
- D4 mL
Answer key
- 1. D · Treat an acute migraine attack
- 2. B · Lithium
- 3. B · Olanzapine
- 4. C · The volume of plasma cleared of the drug per unit of time
- 5. D · Deep intramuscular only
- 6. D · They reduce protective prostaglandins in the stomach lining
- 7. C · Lorazepam is cleared by simple conjugation and has no active metabolites
- 8. C · 0.4 mL
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