感染控制与患者安全
方法
- 对每位患者都从标准预防开始:手卫生、针对预期暴露的个人防护装备、安全使用锐器。
- 按传播途径追加预防措施:接触传播(隔离衣、手套)、飞沫传播(外科口罩)、空气传播(N95、负压病房)。
- 保持无菌物品的无菌状态:如有疑问就视为不无菌;更换,绝不擦拭。
- 预防环境中的伤害:防跌倒措施,约束仅作为最后手段,火灾时用 RACE 和 PASS。
- 核对给药的正确原则、两个身份识别信息,以及对高警示药物的额外保障;报告差错和险兆事件。
公式表、每个专题的关键方法步骤和 40 道练习题,完整解答附在最后。
On the first step of the WHO analgesic ladder, which drugs are used?
After treatment for hypoglycaemia a patient's glucose is now 5.2 mmol/L (94 mg/dL) and the next meal is hours away. What should the nurse do next?
Before a blood transfusion is started, which check is required?
某病区把浓氯化钾药瓶放在病房备用药品柜中。为什么许多安全指南建议不要这样做?
A patient has a serum potassium of 2.9 mEq/L. Which finding should the nurse expect?
A patient has central chest pain that started 30 minutes ago at rest and has not eased with rest or nitroglycerin. What does this suggest?
What is one advantage of a direct oral anticoagulant (DOAC) such as apixaban compared with warfarin?
护理水封式胸腔引流时,哪项做法正确?
A patient on warfarin for atrial fibrillation has a target INR of 2.0–3.0. How does the usual target for a patient with a mechanical mitral valve compare?
A patient with ongoing hemolytic anemia has an HbA1c of 4.6%, but home glucose readings are often 180–220 mg/dL (10–12 mmol/L). What best explains the gap?
A patient with a peanut allergy is taught to use an adrenaline auto-injector. Which statement is correct?
A man on long-term testosterone therapy has a rising haematocrit. Why is this important?
Why is active tuberculosis treated with several drugs for at least six months?
A patient being treated for infective endocarditis of the mitral valve suddenly develops slurred speech and weakness of the right arm. What is the most likely cause?
Which picture fits Brown-Séquard syndrome?
A patient's glucose is 6.2 mmol/L (112 mg/dL) at 03:00 and 12 mmol/L (216 mg/dL) before breakfast. No hypoglycaemia occurred overnight. What is the most likely explanation?
Which description fits a category (stage) 4 pressure ulcer?
After several days of a tight CPAP mask, a patient has a red, broken area on the bridge of the nose. What is this, and what should the nurse do?
A woman 2 hours after birth has a temperature of 37.8 °C (100.0 °F), a firm fundus and normal lochia. What is the most likely cause?
一名妊娠 10 周的女性已呕吐数天,尿中有酮体,体重下降了 6%,站立时头晕。优先事项是什么?
哪项发现提示主动脉缩窄?
Two children with cystic fibrosis are admitted to the same ward. Which precaution is important?
Wernicke 脑病的经典三联征是什么?
一名服用氯氮平已一年的患者戒烟了。为什么这很重要?
练习题(虚构数值,不作为临床指导)。 一位患者身高 184 cm。按 1 in = 2.54 cm,求以英寸表示的身高h。取到一位小数。
练习题(虚构数值,不作为临床指导)。 一个班次中,患者摄入了2 杯 / 茶, 1½ fl oz / 果汁, 4 tbsp / 液体营养补充剂。按给出的等量关系,求以 mL 表示的口服总摄入量V。
5 mL 的 10%(w/v)溶液中含有多少毫克药物 m?
处方为 620 单位的药物,药液规格为 1000 单位/mL。请用 1 mL 注射器抽取剂量:应给多少体积 V?
用滴系数为 10 滴/mL 的输液器在 2 小时内输入 500 mL。求滴速 R(滴/分)。 取整到最接近的整数。
一袋液体在 100 mL 中含药 400 mg,以 25 mL/h 的速度输注。患者每小时获得多少毫克 D?
练习题(虚构数值,不作为临床指导)。 一份输液含普通胰岛素 100 单位,容量 100 mL。医嘱为 2 units/h。求泵速 R,以 mL/h 计。 保留一位小数。
练习题(虚构数值,不作为临床指导)。 一袋中含dopamine 400 mg,容量 250 mL。医嘱为 15 mcg/kg/min,患者体重 105 kg。输液泵速率 R 应设为多少 mL/h? 保留一位小数。
练习题(虚构数值,不作为临床指导)。 记录显示了一名患者在一个 8 小时班次中的出入量。静脉输液在整个班次中按所示速率输注。求液体平衡 B = 入量 − 出量,以 mL 计(答案为负表示净丢失)。
练习题(虚构数值,不作为临床指导)。 一袋 500 mL 的液体用输液泵以 125 mL/h 输注。到 10:00 时已输入 200 mL。还要多少小时 t 袋子才会输完? 保留一位小数。
练习题(虚构数值,不作为临床指导)。 用 Morse 跌倒评分评估一位练习患者:过去 3 个月内的跌倒史: 是; 次要诊断: 是; 行走辅助: 无、卧床休息或由护士协助; 静脉输液或封管: 否; 步态: 虚弱; 精神状态: 高估或忘记自身局限。求 Morse 总分MFS。
练习题(虚构数值,不作为临床指导)。 一名练习用新生儿出生后 1 分钟时:全身皮肤粉红,心率 130 次/分,刺激时哭叫、咳嗽或打喷嚏,活动活跃,呼吸良好,哭声响亮。 为 Apgar 评分并点击该评分的解读。
某练习血气显示 PaCO₂ 31 mmHg (4.1 kPa)。利用规则:在慢性呼吸性碱中毒中,PaCO₂ 每比 40 低出 10 mmHg,HCO₃⁻ 下降 5 mmol/L,以HCO₃⁻ 24 mmol/L 为起点,求预期HCO₃⁻。
练习数值:Na⁺ 141,Cl⁻ 115,HCO₃⁻ 11 mmol/L,白蛋白 36 g/L。求经白蛋白校正的阴离子间隙 AGc = AG + 0.25·(40 − 白蛋白)。
在这条规则的 II 导联心电图上测量 QT 间期和 R–R 间期,然后用 Bazett 公式 QTc = QT/√RR(均以秒计)计算经心率校正的QTc。答案以秒表示,保留三位小数。
这条 II 导联心电图显示房室传导阻滞,所以心房和心室以不同的频率搏动。QRS 波群是规则的:求出心室率(单位:次/分,1500 法,取整数)。
答案: B · Non-opioids such as paracetamol (acetaminophen) or an NSAID
The WHO ladder starts with non-opioids, adds a weak opioid for moderate pain and a strong opioid for severe pain, with adjuvants at any step. It is still widely taught, although current WHO guidance stresses individual assessment over a strict step-by-step approach.
答案: C · Give a longer-acting carbohydrate, such as a sandwich
Fast-acting glucose raises the level quickly but briefly. A starchy snack, or the next meal if due, keeps it from falling again. The episode is recorded and its cause reviewed.
答案: D · The patient’s identity is checked against the blood product and its paperwork at the bedside
Wrong-patient transfusion can cause a fatal ABO reaction, so the final check is always done at the bedside, with positive patient identification against the product label, compatibility tag and order. Many US hospitals require two qualified people for this check, while UK guidance allows one trained person if positive identification is used. Local policy decides who checks.
答案: B · 误将未稀释的浓缩液给药可使心脏停搏
浓氯化钾未经稀释或输注过快可使心脏停搏。把浓缩液从病房常规备用药中撤出,改用预混即用的输液袋,是广泛推荐的安全措施。
答案: B · Muscle weakness and U waves on the ECG
Hypokalemia causes muscle weakness, cramps and arrhythmias, with flattened T waves and U waves on the ECG. Peaked T waves are a sign of hyperkalemia.
答案: B · A possible myocardial infarction that needs urgent action
Chest pain that lasts and is not relieved by rest or nitroglycerin suggests acute coronary syndrome, possibly a heart attack. The nurse acts at once: ECG, escalation and prescribed treatment.
答案: B · It does not need routine INR monitoring
DOACs have predictable effects so INR monitoring is not needed. They still cause bleeding, have some interactions and need kidney function checked.
答案: A · 保持引流瓶低于胸部水平
引流瓶应低于胸部,防止液体和气体回流入胸膜腔。常规夹管可能导致张力性气胸。
答案: B · Higher, about 2.5–3.5
Mechanical heart valves, especially in the mitral position, have a high risk of thrombosis, so the INR target is usually higher, about 2.5–3.5. An INR of 5 or more carries a high bleeding risk.核对依据: Label: WARFARIN SODIUM tablet · DailyMed (NLM/FDA) (2012)
答案: A · Short red cell life span lowers the HbA1c falsely
HbA1c reflects glucose attached to hemoglobin over the red cell life span. In hemolysis, red cells are younger and have less time to bind glucose, so HbA1c is falsely low. Glucose monitoring or other markers are used instead.核对依据: The A1C Test & Diabetes · NIDDK (NIH) (2018); Hemoglobin A1C (HbA1c) Test · MedlinePlus (NIH) (2025)
答案: B · Call emergency services after using it, even if symptoms improve
Anaphylaxis can recur after the adrenaline wears off (a biphasic reaction). The person always calls for help after using it, carries two auto-injectors and uses adrenaline early.
答案: B · Testosterone raises red cell production, increasing clot risk
Testosterone increases erythropoiesis and can cause polycythaemia, which increases blood viscosity and thrombosis risk. Haematocrit is monitored, and the dose may be reduced or paused.
答案: D · To kill slow-growing bacteria and prevent drug resistance
Mycobacterium tuberculosis grows slowly and has resistant mutants in any large population. A combination (for example rifampicin, isoniazid, pyrazinamide and ethambutol at first) kills susceptible and resistant bacteria and prevents resistance. Stopping early risks relapse and multidrug-resistant TB.
答案: B · An embolus from a valve vegetation causing a stroke
Vegetations on the mitral or aortic valve can break off and embolise to the brain, kidneys, spleen or limbs. Sudden focal neurological signs suggest an embolic stroke: the nurse calls for urgent help, checks the blood glucose to exclude hypoglycaemia and expects urgent brain imaging. Thrombolysis is generally avoided in endocarditis because of the bleeding risk.
答案: C · Weakness on the same side and loss of pain on the opposite side
Damage to one side of the spinal cord, often from a stab wound, causes motor loss and loss of proprioception on the same side, and loss of pain and temperature on the opposite side. The pain fibres cross soon after entering the cord.
答案: A · The dawn phenomenon from early-morning hormones
In the dawn phenomenon, cortisol and growth hormone rise in the early morning and push glucose up without a preceding hypo. A night-time hypo followed by rebound hyperglycaemia would suggest the Somogyi effect. The prescriber can adjust the insulin regimen.
答案: D · Full-thickness loss with exposed bone, tendon or muscle
Category 4 has full-thickness loss with exposed bone, tendon or muscle and often undermining or tunnelling. Category 3 reaches the fat but does not expose bone, tendon or muscle.
答案: A · A device-related pressure injury; protect skin and refit the mask
Masks, tubes, catheters and splints can cause pressure injuries. The nurse checks the skin under devices regularly, uses protective dressings, adjusts fit and repositions where possible.
答案: B · Dehydration after labour
A slight rise in temperature in the first 24 hours is often due to dehydration and the effort of labour. Fluids are encouraged and temperature rechecked. A fever of 38 °C (100.4 °F) or more, especially after 24 hours, suggests infection.
答案: C · 按处方静脉补液和补充电解质以纠正脱水
这些是妊娠剧吐伴脱水的征象。优先事项是静脉补液、补充电解质、止吐药,并按处方补充维生素,如硫胺素。
答案: C · 上肢血压高于下肢,股动脉搏动减弱
主动脉缩窄使主动脉变窄,通常位于通往手臂的动脉之后,因此上肢压力高而下肢压力低,股动脉搏动减弱或延迟。
答案: D · Keep them apart, not sharing rooms, equipment or play areas
People with CF can pass bacteria such as Pseudomonas aeruginosa and Burkholderia cepacia to each other, worsening lung disease. Children with CF are kept apart in hospital and clinics, and equipment is not shared.
答案: C · 意识模糊、共济失调和眼球运动异常
只有部分患者表现出完整的三联征,因此对任何有风险的人都应给予硫胺素。如不治疗,可发展为 Korsakoff 综合征。
答案: D · 氯氮平水平可能升高,增加镇静和惊厥等副作用的风险
烟雾诱导代谢氯氮平的肝酶 CYP1A2。戒烟后,血药水平可大幅升高,因此应通知开医嘱者,并监测血药水平和副作用。
答案: h = 72.4 in
家用计量和体重:护理考试使用取整的等量关系:1 茶匙(tsp)= 5 mL,1 汤匙(tbsp)= 15 mL = 3 tsp,1 液量盎司(fl oz)= 30 mL = 2 tbsp,1 杯 = 8 fl oz = 240 mL。体重方面,1 kg = 2.2 lb,1 lb = 16 oz;长度方面,1 英寸 = 2.54 cm。设置换算时,要让你不需要的单位相互约去。
答案: V = 585 mL
家用计量和体重:护理考试使用取整的等量关系:1 茶匙(tsp)= 5 mL,1 汤匙(tbsp)= 15 mL = 3 tsp,1 液量盎司(fl oz)= 30 mL = 2 tbsp,1 杯 = 8 fl oz = 240 mL。体重方面,1 kg = 2.2 lb,1 lb = 16 oz;长度方面,1 英寸 = 2.54 cm。设置换算时,要让你不需要的单位相互约去。
答案: m = 500 mg
Solution strengths: a percentage strength is grams per 100 mL, so 1% = 1 g/100 mL = 10 mg/mL. A ratio strength 1:1000 means 1 g in 1000 mL = 1 mg/mL; 1:10 000 is 0.1 mg/mL. For a dilution the amount of drug stays the same: C₁·V₁ = C₂·V₂.
答案: V = 0.62 mL
抽取剂量:体积 = (处方剂量/药物浓度) × 药物体积。先换算成相同的单位,再检查该体积是否适合注射器,并落在它的某一个刻度上。
在这支 1 mL 的注射器上,每条小刻度线代表 0.01 mL。
答案: R = 42 gtt/min
输注速率:输液泵按 mL/h = 体积/时间(小时)设定。重力滴注按每分钟滴数计:gtt/min = 体积 (mL) × 滴系数 (gtt/mL)/时间 (min)。 滴系数印在输液器包装上:普通输液器为 10、15 或 20 gtt/mL(输血器在美国常为 10 gtt/mL,在英国为 15),微量输液器为 60 gtt/mL。务必使用题目或包装给出的滴系数。
床旁取最接近的整滴:42 滴/分。
答案: D = 100 mg/h
输注速率:输液泵按 mL/h = 体积/时间(小时)设定。重力滴注按每分钟滴数计:gtt/min = 体积 (mL) × 滴系数 (gtt/mL)/时间 (min)。 滴系数印在输液器包装上:普通输液器为 10、15 或 20 gtt/mL(输血器在美国常为 10 gtt/mL,在英国为 15),微量输液器为 60 gtt/mL。务必使用题目或包装给出的滴系数。
答案: R = 2 mL/h
肝素和胰岛素输注:浓度 = 袋中单位数/袋容量 (units/mL)。泵速 (mL/h) = 每小时单位数/浓度,每小时单位数 = mL/h × 浓度。按体重给药时,先求 units/h = units/kg/h × 体重。推注体积 = 所需单位数/药瓶规格。 这些数字仅供练习;在临床工作中务必遵循当地规程,高危剂量须经双人核对。
答案: R = 59.1 mL/h
滴定输注:先求以 mcg/mL 计的浓度(mg × 1000/mL)。按体重给药时,mcg/min = mcg/kg/min × 体重。然后 mL/h = mcg/min × 60/浓度。反推时,mcg/kg/min = mL/h × 浓度/(60 × 体重)。 这些数字仅供练习;在临床工作中务必遵循当地规程,高危剂量须经双人核对。
答案: B = 295 mL
出入量:入量计入所有进入体内的液体(口服液体、静脉输液、静脉用药及冲管液、管饲);冰屑按其体积的一半计。出量计入尿液、引流液、呕吐物和其他丢失。平衡 = 总入量 − 总出量;平衡为负表示净丢失。 这些数字仅供练习;在临床工作中务必遵循当地规程,高危剂量须经双人核对。
为正:摄入的液体多于排出的液体。
答案: t = 2.4 h
输液时间:时间 (h) = 待输体积 (mL)/速率 (mL/h);使用袋中剩余的体积,而不是袋的容量。已输入体积 = 速率 × 时间。把小数小时换算为小时和分钟时,用小数部分 × 60(0.5 h = 30 min,而不是 50 min)。 这些数字仅供练习;在临床工作中务必遵循当地规程,高危剂量须经双人核对。
约为 2 h 24 min,所以袋子大约在 12:24 输完。
答案: MFS = 65
Morse 跌倒评分:六个条目。跌倒史:否 0 分,是 25 分。次要诊断:否 0 分,是 15 分。行走辅助:无、卧床休息或护士协助 0 分;拐杖、手杖或助行器 15 分;扶着家具 30 分。静脉输液或封管:否 0 分,是 20 分。步态:正常、卧床休息或轮椅 0 分;虚弱 10 分;受损 20 分。精神状态:了解自身局限 0 分;高估或忘记自身局限 15 分。总分为 0 至 125。各医院的风险分界值不同;常用的一套是 0–24 低风险,25–44 中度风险,45 及以上为高风险。
答案: 令人放心
Apgar 评分:五项体征,每项评 0、1 或 2 分,在出生后 1 分钟和 5 分钟检查。外观(肤色):青紫或苍白 0 分,躯干粉红、四肢青紫 1 分,全身粉红 2 分。脉搏:无 0 分,低于 100 次/分 1 分,100 次/分或以上 2 分。反射(反射应激性):无 0 分,做鬼脸 1 分,哭叫、咳嗽或打喷嚏 2 分。肌张力(活动):松软 0 分,略有屈曲 1 分,活动活跃 2 分。呼吸:无 0 分,缓慢或不规则、哭声微弱 1 分,良好、哭声响亮 2 分。总分 7–10 为令人放心,4–6 为中度异常,0–3 为低。
答案: HCO₃⁻ = 19.5 mmol/L
预期代偿:代谢性酸中毒时,温特公式预测 PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg;实测值高于该范围提示合并呼吸性酸中毒,低于该范围提示合并呼吸性碱中毒。阴离子间隙 AG = Na⁺ − (Cl⁻ + HCO₃⁻),正常约为 8–12 mmol/L,用于区分高阴离子间隙与正常阴离子间隙代谢性酸中毒;低白蛋白会掩盖升高的间隙(白蛋白低于 4.0 的部分,每 g/dL 加 2.5)。Δ 比值 (AG − 12)/(24 − HCO₃⁻) 约在 0.8 到 2 之间符合单纯高间隙酸中毒(有些教材用 1 代替 0.8),低于此范围提示合并正常间隙酸中毒,高于 2 提示合并代谢性碱中毒。
答案: AGc = 16 mmol/L
预期代偿:代谢性酸中毒时,温特公式预测 PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg;实测值高于该范围提示合并呼吸性酸中毒,低于该范围提示合并呼吸性碱中毒。阴离子间隙 AG = Na⁺ − (Cl⁻ + HCO₃⁻),正常约为 8–12 mmol/L,用于区分高阴离子间隙与正常阴离子间隙代谢性酸中毒;低白蛋白会掩盖升高的间隙(白蛋白低于 4.0 的部分,每 g/dL 加 2.5)。Δ 比值 (AG − 12)/(24 − HCO₃⁻) 约在 0.8 到 2 之间符合单纯高间隙酸中毒(有些教材用 1 代替 0.8),低于此范围提示合并正常间隙酸中毒,高于 2 提示合并代谢性碱中毒。
校正后高于约 12:阴离子间隙升高。
答案: QTc = 0.448 s
QT 与 QTc:QT 间期从 QRS 波群起点到 T 波终点。它随心率加快而缩短,因此要用以秒为单位的 R–R 间期按心率校正:Bazett QTc = QT/√RR,Fridericia QTc = QT/∛RR。多数教科书使用 Bazett 公式;它在心率快时校正过度,此时宜用 Fridericia。各参考标准的界限不同:QTc 男性高于约 0.45 s、女性高于约 0.46 s 通常称为延长,高于 0.50 s 称为明显延长。
在通常上限之内(男性约 0.45 s,女性约 0.46 s)。(448 ms)
答案: 心室率 = 27 bpm
房室传导阻滞:逐个标出 P 波,检查哪些 P 波后面跟着 QRS。一度:每个 P 波都下传,PR 恒定且大于 0.20 s。二度 I 型(Mobitz I,文氏现象):PR 逐搏延长,直到一个 P 波未下传,然后周期重新开始(成组搏动)。二度 II 型(Mobitz II):下传搏动的 PR 保持恒定,P 波突然不下传;QRS 常增宽。三度(完全性)阻滞:P 波和 QRS 波群各自规则但互相独立,PR 随机变化,心房率快于逸搏率(交界性逸搏 40–60 次/分,QRS 窄;室性逸搏 20–40 次/分,QRS 宽)。2:1 阻滞仅凭一份条带无法判断是 I 型还是 II 型。
三度阻滞,伴宽 QRS 室性逸搏(通常为 20–40 次/分)。
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