ورقة عمل علم الأدوية مع الإجابات

Celecoxib selectively inhibits which enzyme?

1. ALipoxygenase
2. BPhospholipase A2
3. CCyclo-oxygenase-2 (COX-2)
4. DCyclo-oxygenase-1 (COX-1)

Which intramuscular site is recommended for infants?

1. ADeltoid
2. BVentral forearm
3. CVastus lateralis (outer thigh)
4. DDorsogluteal (upper outer buttock)

Naltrexone helps in alcohol use disorder because it:

1. ACauses vomiting and flushing whenever alcohol is drunk
2. BBlocks opioid receptors, reducing reward and craving
3. CReplaces alcohol as a sedative
4. DSpeeds up the liver breakdown of alcohol

Why is testing for HLA-B*15:02 recommended before carbamazepine in people of some Asian ancestries?

1. AThis gene variant makes carbamazepine ineffective
2. BThis gene variant speeds up the kidney excretion of carbamazepine
3. CIt greatly raises the risk of Stevens–Johnson syndrome
4. DThis gene variant causes carbamazepine to raise blood glucose

Which assessment is most important during IV mannitol therapy?

1. ALiver enzymes and signs of jaundice
2. BPlatelet count and signs of bleeding
3. CUrine output, electrolytes and signs of fluid overload
4. DBlood glucose before meals and signs of hypoglycaemia

Why are patients taking simvastatin often advised to avoid large amounts of grapefruit juice?

1. AGrapefruit blocks cholesterol absorption and causes low cholesterol
2. BGrapefruit makes the tablet dissolve in the mouth
3. CGrapefruit inhibits CYP3A4 in the gut, raising simvastatin levels and myopathy risk
4. DGrapefruit speeds up simvastatin breakdown in the liver, so the drug stops working

Why do infants absorb more of a topical corticosteroid than adults?

1. AThey have more skin area per kilogram and thinner skin
2. BTheir skin contains no blood vessels
3. CTheir liver changes the cream into a much stronger form
4. DInfants do not absorb topical drugs at all

A drug is ordered at 5 micrograms/kg/min for an 80 kg patient. The infusion contains 1,600 micrograms per mL. What rate in mL/h is needed?

1. A4 mL/h
2. B25 mL/h
3. C150 mL/h
4. D15 mL/h