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1Formulas and methods
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
2Practice problems
1.ECG rhythm strip interpretationMedium
Interpret this lead II rhythm strip. Which rhythm is it? Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1sinus tachycardia
2atrial flutter, 2:1 conduction
3atrial flutter, 4:1 conduction
4normal sinus rhythm
2.ECG rhythm strip interpretationHard
This lead II strip shows second-degree AV block type I (Wenckebach). Measure the PR interval of the last conducted beat before a non-conducted P wave (the longest PR), in seconds.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
longest PR = s
3.Human physiologyMedium
Where does the final activation step of vitamin D (1-alpha hydroxylation) take place?
AKidney
BSmall intestine
CLiver
DSkin
4.Human physiologyHard
Why does ketoacidosis typically develop in untreated type 1 diabetes but rarely in type 2?
AEven low insulin levels suppress lipolysis and ketogenesis
BType 2 patients cannot make ketones at all
CKetones are only made in children
DType 1 patients have more glucagon receptors
3Solutions
1.ECG rhythm strip interpretation
Answer: atrial flutter, 4:1 conduction
Rhythm criteria (lead II): sinus rhythm has an upright P wave before every QRS, a constant PR of 0.12–0.20 s and a narrow QRS: normal sinus rhythm at 60–100/min, sinus bradycardia below 60, sinus tachycardia above 100. Atrial fibrillation: no P waves, a fibrillatory baseline and an irregularly irregular R–R. Atrial flutter: sawtooth flutter waves at about 250–350/min with a fixed conduction ratio such as 2:1 or 4:1. First-degree AV block: sinus rhythm with a constant PR above 0.20 s. Junctional rhythm: narrow QRS at 40–60/min with absent or inverted P waves (PR below 0.12 s, or P after the QRS). A PVC is an early, wide (0.12 s or more), bizarre QRS without a P wave, with the T wave in the opposite direction and usually a full compensatory pause; in bigeminy every second beat is a PVC.
Five steps
1. Rate: R–R = 24 small boxes, 1500 ÷ 24 ≈ 63 per minute.
2. Rhythm: regular, every R–R is 0.96 s.
3. P waves: none; regular sawtooth flutter waves every 0.24 s (250 per minute), 4 for each QRS.
4. PR interval: not measurable.
5. QRS: 0.10 s, narrow (below 0.12 s).
Interpretation
atrial flutter, 4:1 conduction
Answer
atrial flutter, 4:1 conduction
2.ECG rhythm strip interpretation
Answer:longest PR = 0.3 s
AV blocks: march out the P waves and check which ones are followed by a QRS. First-degree: every P conducted, PR constant and above 0.20 s. Second-degree type I (Mobitz I, Wenckebach): the PR lengthens from beat to beat until one P wave is not conducted, then the cycle starts again (group beating). Second-degree type II (Mobitz II): the PR of the conducted beats stays constant, and P waves are suddenly not conducted; the QRS is often wide. Third-degree (complete) block: P waves and QRS complexes are each regular but independent, the PR varies at random and the atrial rate is faster than the escape rate (junctional 40–60/min with a narrow QRS, ventricular 20–40/min with a wide QRS). A 2:1 block cannot be called type I or type II from one strip.
March out the P waves
P–P = 0.96 s, regular; one P wave in every 3 is not conducted
PR in each group
PR₁ = 0.16 s, PR₂ = 0.30 s
Answer
longest PR = 0.3 s
The biggest step in PR comes between the first and second beats of a group; later steps are smaller, which is why the R–R intervals shorten before the pause.
3.Human physiology
Answer: A · Kidney
Why this is the answer
Vitamin D is made in the skin or eaten, hydroxylated in the liver, and then activated to calcitriol in the kidney. Kidney failure therefore causes vitamin D deficiency.
Answer
A · Kidney
4.Human physiology
Answer: A · Even low insulin levels suppress lipolysis and ketogenesis
Why this is the answer
Insulin strongly inhibits lipolysis and hepatic ketone production. In type 1 there is almost no insulin, so fatty acids flood the liver and ketones build up.
Answer
A · Even low insulin levels suppress lipolysis and ketogenesis