1Formulas and methods
ECG rhythm strip interpretation
- Paper (25 mm/s, 10 mm/mV)
- 1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
- Heart rate, regular rhythm
- 300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
- Heart rate, irregular rhythm
- QRS complexes in 6 s × 10
- Normal PR interval
- 0.12–0.20 s
- Normal QRS duration
- < 0.12 s
- QTc (Bazett)
- QT/√RR
- QTc (Fridericia)
- QT/∛RR
- QTc (Framingham)
- QT + 154·(1 − RR)
- Sinus rates
- bradycardia < 60, normal 60–100, tachycardia > 100 /min
- Escape rates
- junctional 40–60, ventricular 20–40 /min
- Fast rhythms
- SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
- Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
- Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
- P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
- PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
- QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
2Practice problems
1.ECG rhythm strip interpretationMedium
Measure the QT interval and the R–R interval on this regular lead II strip, then calculate the rate-corrected QTc with Bazett’s formula QTc = QT/√RR (both in seconds). Give the answer in seconds to three decimals.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
QTc = s
2.ECG rhythm strip interpretationHard
This lead II strip shows an AV block, so the atria and the ventricles beat at different rates. The QRS complexes are regular: find the ventricular rate in beats per minute (1500 method, whole number).
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
ventricular rate = bpm
3.Human physiologyMedium
What is anatomical dead space?
- AThe space between the two pleural layers
- BAlveoli that have collapsed completely
- CThe air that stays in the lungs after full exhalation (residual volume)
- DThe volume of the conducting airways where no gas exchange happens
4.Human physiologyHard
A young woman has muscle weakness that gets worse with repeated use and improves with an acetylcholinesterase inhibitor. What is the most likely mechanism?
- ADemyelination of central nervous system tracts
- BLoss of motor neurons in the spinal cord
- CA defect in the dystrophin protein of muscle
- DAntibodies against acetylcholine receptors at the neuromuscular junction
3Solutions
1.ECG rhythm strip interpretation
Answer: QTc = 0.401 s
QT and QTc: the QT interval runs from the start of the QRS complex to the end of the T wave. It shortens as the heart rate rises, so it is corrected for rate with the R–R interval in seconds: Bazett QTc = QT/√RR and Fridericia QTc = QT/∛RR. Bazett is the formula most textbooks use; it over-corrects at fast rates, where Fridericia is preferred. Limits differ between references: a QTc above about 0.45 s in men or 0.46 s in women is usually called prolonged, and above 0.50 s markedly prolonged.
Measure
QT = 8.5 × 0.04 = 0.34 s
RR = 18 × 0.04 = 0.72 s
Bazett’s formula
QTc = 0.34/√0.72 = 0.34/0.8485 = 0.401 s
Within the usual limits (about 0.45 s for men, 0.46 s for women). (401 ms)
2.ECG rhythm strip interpretation
Answer: ventricular rate = 33 bpm
AV blocks: march out the P waves and check which ones are followed by a QRS. First-degree: every P conducted, PR constant and above 0.20 s. Second-degree type I (Mobitz I, Wenckebach): the PR lengthens from beat to beat until one P wave is not conducted, then the cycle starts again (group beating). Second-degree type II (Mobitz II): the PR of the conducted beats stays constant, and P waves are suddenly not conducted; the QRS is often wide. Third-degree (complete) block: P waves and QRS complexes are each regular but independent, the PR varies at random and the atrial rate is faster than the escape rate (junctional 40–60/min with a narrow QRS, ventricular 20–40/min with a wide QRS). A 2:1 block cannot be called type I or type II from one strip.
Atrial rate
P–P = 17 small boxes = 0.68 s → 1500 ÷ 17 = 88.24 ≈ 88 per minute
Ventricular rate
R–R = 46 small boxes = 1.84 s → 1500 ÷ 46 = 32.61 ≈ 33 per minute
Answer
ventricular rate = 33 bpm
ventricular rate = 33 bpm
Third-degree block with a wide-complex ventricular escape (usually 20–40 per minute).
3.Human physiology
Answer: D · The volume of the conducting airways where no gas exchange happens
Why this is the answer
Anatomical dead space (about 150 ml) is air in the nose, trachea and bronchi. It is moved with every breath but never reaches the alveoli.
D · The volume of the conducting airways where no gas exchange happens
4.Human physiology
Answer: D · Antibodies against acetylcholine receptors at the neuromuscular junction
Why this is the answer
In myasthenia gravis, autoantibodies reduce the number of functional acetylcholine receptors. Blocking acetylcholinesterase leaves more ACh to bind the remaining receptors.
D · Antibodies against acetylcholine receptors at the neuromuscular junction