1Formulas and methods
ECG rhythm strip interpretation
- Paper (25 mm/s, 10 mm/mV)
- 1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
- Heart rate, regular rhythm
- 300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
- Heart rate, irregular rhythm
- QRS complexes in 6 s × 10
- Normal PR interval
- 0.12–0.20 s
- Normal QRS duration
- < 0.12 s
- QTc (Bazett)
- QT/√RR
- QTc (Fridericia)
- QT/∛RR
- QTc (Framingham)
- QT + 154·(1 − RR)
- Sinus rates
- bradycardia < 60, normal 60–100, tachycardia > 100 /min
- Escape rates
- junctional 40–60, ventricular 20–40 /min
- Fast rhythms
- SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
- Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
- Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
- P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
- PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
- QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
2Practice problems
1.ECG rhythm strip interpretationMedium
Measure the QT interval and the R–R interval on this regular lead II strip, then calculate the rate-corrected QTc with Bazett’s formula QTc = QT/√RR (both in seconds). Give the answer in seconds to three decimals.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
QTc = s
2.ECG rhythm strip interpretationHard
This lead II strip shows an AV block, so the atria and the ventricles beat at different rates. Measure the P–P interval and find the atrial rate in beats per minute (1500 method, whole number).
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
atrial rate = bpm
3.Human physiologyMedium
Which cells in the stomach secrete hydrochloric acid?
- AGoblet cells
- BChief cells
- CG cells
- DParietal cells
4.Human physiologyHard
Why is severe hyperkalaemia dangerous for the heart?
- AIt speeds up the SA node until tachycardia causes fainting
- BIt depolarises cardiac cells, inactivating sodium channels and causing arrhythmias
- CIt blocks the binding of calcium to troponin
- DIt hyperpolarises cardiac cells, so they can never fire
3Solutions
1.ECG rhythm strip interpretation
Answer: QTc = 0.375 s
QT and QTc: the QT interval runs from the start of the QRS complex to the end of the T wave. It shortens as the heart rate rises, so it is corrected for rate with the R–R interval in seconds: Bazett QTc = QT/√RR and Fridericia QTc = QT/∛RR. Bazett is the formula most textbooks use; it over-corrects at fast rates, where Fridericia is preferred. Limits differ between references: a QTc above about 0.45 s in men or 0.46 s in women is usually called prolonged, and above 0.50 s markedly prolonged.
Measure
QT = 7.5 × 0.04 = 0.30 s
RR = 16 × 0.04 = 0.64 s
Bazett’s formula
QTc = 0.30/√0.64 = 0.30/0.8 = 0.375 s
Within the usual limits (about 0.45 s for men, 0.46 s for women). (375 ms)
2.ECG rhythm strip interpretation
Answer: atrial rate = 65 bpm
AV blocks: march out the P waves and check which ones are followed by a QRS. First-degree: every P conducted, PR constant and above 0.20 s. Second-degree type I (Mobitz I, Wenckebach): the PR lengthens from beat to beat until one P wave is not conducted, then the cycle starts again (group beating). Second-degree type II (Mobitz II): the PR of the conducted beats stays constant, and P waves are suddenly not conducted; the QRS is often wide. Third-degree (complete) block: P waves and QRS complexes are each regular but independent, the PR varies at random and the atrial rate is faster than the escape rate (junctional 40–60/min with a narrow QRS, ventricular 20–40/min with a wide QRS). A 2:1 block cannot be called type I or type II from one strip.
Atrial rate
P–P = 23 small boxes = 0.92 s → 1500 ÷ 23 = 65.22 ≈ 65 per minute
Ventricular rate
5 QRS complexes in 6 s × 10 = 50 per minute
Second-degree type I (Wenckebach): 4 P waves for every 3 QRS complexes.
3.Human physiology
Answer: D · Parietal cells
Why this is the answer
Parietal cells secrete HCl and intrinsic factor. Chief cells secrete pepsinogen and G cells secrete gastrin.
4.Human physiology
Answer: B · It depolarises cardiac cells, inactivating sodium channels and causing arrhythmias
Why this is the answer
High extracellular potassium makes the resting potential less negative. Many fast sodium channels then become inactivated, slowing conduction and risking fatal arrhythmias.
B · It depolarises cardiac cells, inactivating sodium channels and causing arrhythmias