Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
A patient with COPD uses an inhaled corticosteroid combination inhaler. Which risk should the nurse be aware of?
AAn increased risk of high blood pressure crises
BHearing loss after every dose
CA sharp drop in potassium after each dose
DAn increased risk of pneumonia
2.Med-surg: cardiovascular & respiratoryHard
A patient on an unfractionated heparin infusion has a nosebleed that will not stop, and the aPTT is far above the target range. What is the most appropriate action?
AStop the infusion, inform the prescriber and anticipate protamine
BContinue the infusion at the same rate and pack the nose firmly
CGive vitamin K and continue the infusion at a slightly lower rate
DIncrease the infusion, as the aPTT will settle
3.Med-surg: neuro, endocrine & renalMedium
Which statement about giving IV potassium is correct?
AIt is diluted and given through an infusion pump, never as a bolus
BIt can be given quickly as a push to correct the level fast
CIt is safest given through a small vein in the hand at a fast rate
DIt needs no monitoring at all once the infusion is running
4.Med-surg: neuro, endocrine & renalHard
An older patient with a UTI is now confused, with a respiratory rate of 24/min, BP 88/50 mmHg and a pulse of 120/min. What should happen?
ATreat the confusion with a sedative
BStart sepsis care at once, with IV antibiotics and fluids
CGive oral antibiotics and recheck in four hours
DEncourage oral fluids and wait for the urine culture
5.Med-surg: GI, perioperative & oncologyMedium
A patient with a new ileostomy has a very high output. What is the main risk?
AConstipation and faecal impaction in the bowel above the stoma
BHigh calcium and kidney stones within days
CFluid overload and swelling of the ankles
DDehydration and loss of sodium, potassium and magnesium
6.Med-surg: GI, perioperative & oncologyHard
A patient on a long-term opioid for chronic pain is admitted for surgery. Which statement is correct?
AThey need lower postoperative opioid doses than opioid-naive patients
BAll opioids should be stopped on admission to prevent addiction
CThe usual opioid is continued, plus extra analgesia, due to tolerance
DThey should receive only paracetamol after the operation is over
7.Clinical nursingMedium
Which blood result often rises in an upper GI bleed because blood is digested in the gut?
ASodium
BGlucose
CCalcium
DUrea (blood urea nitrogen)
8.Clinical nursingHard
A postoperative patient on IV fluids has a sodium of 128 mmol/L and is becoming confused. Which fluid could make this worse if given in large amounts?
A5% glucose (D5W)
BHuman albumin solution
CHartmann's solution (similar to lactated Ringer's)
D0.9% sodium chloride
9.Lab values & electrolytesMedium
A patient who is breathless during a transfusion has hypotension, fever and bilateral lung infiltrates, with no signs of fluid overload. Which complication is most likely?
AA simple allergic reaction with hives
BTransfusion-associated circulatory overload
CA mild febrile nonhemolytic reaction
DTransfusion-related acute lung injury (TRALI)
10.Lab values & electrolytesHard
A patient with a round face, central weight gain and purple stretch marks has a glucose of 210 mg/dL (11.7 mmol/L) and a potassium of 3.1 mEq/L. Which condition fits best?
ADiabetes insipidus
BHypothyroidism
CAdrenal insufficiency
DCushing syndrome
11.Arterial blood gas interpretationMedium
A practice arterial blood gas shows pH 7.51, PaCO₂ 50 mmHg (6.7 kPa) and HCO₃⁻ 39 mmol/L. The primary disorder is metabolic alkalosis. How far is it compensated? Click your answer.
pH 7.51PaCO₂ 50 mmHg (6.7 kPa)HCO₃⁻ 39 mmol/L
1uncompensated
2partially compensated
3fully compensated
12.Arterial blood gas interpretationHard
At sea level, a practice gas taken on 28% oxygen shows PaO₂ 82 mmHg (10.9 kPa) and PaCO₂ 60 mmHg (8.0 kPa). Use PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 to find the A–a gradient.
Interpret this lead II rhythm strip. Which rhythm is it? Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1normal sinus rhythm
2sinus tachycardia
3sinus bradycardia
4first-degree AV block
14.ECG rhythm strip interpretationHard
This patient has a pacemaker. Interpret the lead II strip. Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1sinus rhythm with wide QRS
2paced rhythm, failure to capture
3dual-chamber (AV) paced rhythm
4ventricular paced rhythm
15.Prioritization & delegationMedium
Which patient should the RN see first after receiving a report from the night nurse?
ADay 3 after bowel surgery, wants a shower and hair wash before breakfast
BDay 1 after bowel surgery, new chest pain and heart rate 110/min
CDay 2 after bowel surgery, asking to start a soft diet
DDay 4 after bowel surgery, waiting for discharge teaching
16.Prioritization & delegationHard
A nurse has a needlestick injury from a used needle. What should the nurse do first?
ASqueeze the wound hard and suck it
BScrub the area with bleach
CFinish the shift and report it tomorrow
DWash the area with soap and water
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: D · An increased risk of pneumonia
Why this is the answer
In COPD, inhaled corticosteroids increase the risk of pneumonia. They are used where there are frequent exacerbations or features of asthma, and their benefit is weighed against this risk. Signs of pneumonia should be reported promptly.
Answer
D · An increased risk of pneumonia
2.Med-surg: cardiovascular & respiratory
Answer: A · Stop the infusion, inform the prescriber and anticipate protamine
Why this is the answer
With bleeding and a high aPTT, the heparin infusion is stopped at once and the prescriber informed. Because heparin's effect wears off within hours, stopping is often enough, but protamine sulfate can reverse it. Vitamin K reverses warfarin, not heparin.
Answer
A · Stop the infusion, inform the prescriber and anticipate protamine
3.Med-surg: neuro, endocrine & renal
Answer: A · It is diluted and given through an infusion pump, never as a bolus
Why this is the answer
Concentrated potassium given quickly can cause fatal arrhythmias. IV potassium is given in a diluted, ready-made solution through an infusion pump at a controlled rate, with monitoring of potassium and, at higher rates, the ECG.
Answer
A · It is diluted and given through an infusion pump, never as a bolus
4.Med-surg: neuro, endocrine & renal
Answer: B · Start sepsis care at once, with IV antibiotics and fluids
Why this is the answer
These findings suggest sepsis from a urinary source. Blood cultures, lactate, IV antibiotics within the hour, IV fluids and close monitoring of urine output are started, and senior review is requested.
Answer
B · Start sepsis care at once, with IV antibiotics and fluids
5.Med-surg: GI, perioperative & oncology
Answer: D · Dehydration and loss of sodium, potassium and magnesium
Why this is the answer
High-output ileostomies (often defined as over about 1.5–2 L a day) can cause dehydration, acute kidney injury and electrolyte loss. Fluid balance, weight, urine output and electrolytes are monitored. Patients may need oral rehydration solution and drugs to slow output.
Answer
D · Dehydration and loss of sodium, potassium and magnesium
6.Med-surg: GI, perioperative & oncology
Answer: C · The usual opioid is continued, plus extra analgesia, due to tolerance
Why this is the answer
Patients on long-term opioids have tolerance and physical dependence. Stopping their usual opioid risks withdrawal and uncontrolled pain. Their baseline dose is continued (or converted to another route) and multimodal analgesia added; they often need more opioid than opioid-naive patients, with careful monitoring.
Answer
C · The usual opioid is continued, plus extra analgesia, due to tolerance
7.Clinical nursing
Answer: D · Urea (blood urea nitrogen)
Why this is the answer
Blood proteins digested in the upper GI tract are absorbed and converted to urea, so urea rises out of proportion to creatinine. Urea is part of the Glasgow-Blatchford bleeding score.
Answer
D · Urea (blood urea nitrogen)
8.Clinical nursing
Answer: A · 5% glucose (D5W)
Why this is the answer
The glucose in 5% glucose is metabolised, leaving free water that dilutes the plasma sodium further. Postoperative patients often have raised ADH, so large volumes of hypotonic fluid can cause dangerous hyponatraemia.
Answer
A · 5% glucose (D5W)
9.Lab values & electrolytes
Answer: D · Transfusion-related acute lung injury (TRALI)
Why this is the answer
TRALI is acute lung injury within 6 hours of transfusion, caused by donor antibodies activating neutrophils in the lungs. It causes hypoxia, bilateral infiltrates and often hypotension and fever. TACO, in contrast, causes hypertension and signs of fluid overload.
Answer
D · Transfusion-related acute lung injury (TRALI)
10.Lab values & electrolytes
Answer: D · Cushing syndrome
Why this is the answer
Excess cortisol raises glucose, causes central obesity, a round face and purple striae, and has some mineralocorticoid effect that lowers potassium. Adrenal insufficiency causes low glucose and high potassium.Checked against:Hypercortisolism (Cushing Syndrome) · StatPearls (NCBI Bookshelf) (2025); Hypokalemia · StatPearls (NCBI Bookshelf) (2025)
Answer
D · Cushing syndrome
11.Arterial blood gas interpretation
Answer: partially compensated
Reading a blood gas (ROME): first the pH: below 7.35 is acidaemia, above 7.45 alkalaemia. Then find the value that explains it. PaCO₂ (normal 35–45 mmHg, 4.7–6.0 kPa) is the respiratory part and moves Opposite to the pH in a respiratory disorder; HCO₃⁻ (normal 22–26 mmol/L) is the metabolic part and moves in the same direction as the pH (Respiratory Opposite, Metabolic Equal). The other value shows the compensation: normal means uncompensated; abnormal in the direction that pulls the pH back while the pH is still abnormal means partially compensated; a normal pH with both values abnormal means fully compensated. Ranges differ slightly between laboratories; these are practice values.
ROME, value by value
pH 7.51: alkalaemia (above 7.45)
PaCO₂ 50 mmHg: high (35–45)
HCO₃⁻ 39 mmol/L: high (22–26)
Compensation
partially compensated
Answer
partially compensated
12.Arterial blood gas interpretation
Answer: A–a gradient = 42.64 mmHg
Derived values: calculated serum osmolality is 2·Na⁺ + glucose + urea with all values in mmol/L (2·Na⁺ + glucose/18 + BUN/2.8 with glucose and BUN in mg/dL); normal is about 275–295 mOsm/kg. The P/F ratio is PaO₂ divided by FiO₂ as a fraction. The alveolar oxygen pressure is PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 mmHg at sea level, and the A–a gradient is PAO₂ − PaO₂.
Rhythm criteria (lead II): sinus rhythm has an upright P wave before every QRS, a constant PR of 0.12–0.20 s and a narrow QRS: normal sinus rhythm at 60–100/min, sinus bradycardia below 60, sinus tachycardia above 100. Atrial fibrillation: no P waves, a fibrillatory baseline and an irregularly irregular R–R. Atrial flutter: sawtooth flutter waves at about 250–350/min with a fixed conduction ratio such as 2:1 or 4:1. First-degree AV block: sinus rhythm with a constant PR above 0.20 s. Junctional rhythm: narrow QRS at 40–60/min with absent or inverted P waves (PR below 0.12 s, or P after the QRS). A PVC is an early, wide (0.12 s or more), bizarre QRS without a P wave, with the T wave in the opposite direction and usually a full compensatory pause; in bigeminy every second beat is a PVC.
Five steps
1. Rate: R–R = 26 small boxes, 1500 ÷ 26 ≈ 58 per minute.
2. Rhythm: regular, every R–R is 1.04 s.
3. P waves: upright, one before every QRS, all alike.
4. PR interval: 0.36 s, constant, longer than 0.20 s.
5. QRS: 0.08 s, narrow (below 0.12 s).
Interpretation
first-degree AV block
Answer
first-degree AV block
14.ECG rhythm strip interpretation
Answer: ventricular paced rhythm
Paced rhythms: a pacemaker impulse shows as a narrow vertical pacing spike. After a ventricular spike the QRS is wide (0.12 s or more), because the impulse spreads from the lead through the muscle instead of the conduction system; with right-ventricular pacing it is often mostly negative in lead II. A spike before each P wave means atrial pacing, and a dual-chamber (AV) pacemaker shows an atrial spike and a P wave, then, after the programmed AV delay, a ventricular spike and a wide QRS. Capture means every spike is followed by a depolarisation. Failure to capture is a spike without a P wave or QRS after it; failure to sense (spikes that ignore the patient’s own beats) and failure to pace (no spike when one is due) are the other classic malfunctions.
Five steps
1. Rate: R–R = 25 small boxes, 1500 ÷ 25 ≈ 60 per minute.
2. Rhythm: regular, every R–R is 1.00 s.
3. P waves: none visible; a sharp pacing spike comes just before every QRS.
4. PR interval: not measurable.
5. QRS: 0.16 s, wide, and every spike is followed by a QRS (capture).
Interpretation
ventricular paced rhythm
Answer
ventricular paced rhythm
The paced QRS is wide by nature; do not call it a bundle branch block or a ventricular rhythm.
15.Prioritization & delegation
Answer: B · Day 1 after bowel surgery, new chest pain and heart rate 110/min
Why this is the answer
New chest pain and tachycardia after surgery could be a myocardial infarction or pulmonary embolism. This patient needs immediate assessment; the others have routine needs.
Answer
B · Day 1 after bowel surgery, new chest pain and heart rate 110/min
16.Prioritization & delegation
Answer: D · Wash the area with soap and water
Why this is the answer
The wound is washed with soap and water at once. The nurse then reports the injury immediately so the source patient can be tested and post-exposure treatment considered.