Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
A patient's blood pressure is high in clinic but normal on home readings. Which step best confirms the diagnosis?
AStarting two antihypertensive drugs at once at full dose
BA chest X-ray
CA single repeat reading in the same clinic visit
DAmbulatory or structured home blood pressure monitoring
2.Med-surg: cardiovascular & respiratoryHard
A patient on bisoprolol and diltiazem is dizzy, with a heart rate of 38/min and BP 82/50 mmHg. What is the most appropriate first response?
AWalk the patient around the ward to raise the heart rate
BRecord the observations and recheck them in four hours
CGive the next doses of both drugs early to keep the heart rate steady
DCall for urgent help, assess ABCDE and attach a cardiac monitor
3.Med-surg: neuro, endocrine & renalMedium
During continuous bladder irrigation, 3200 mL drains out in a shift. 2500 mL of irrigation fluid was put in. What is the true urine output?
A2500 mL
B3200 mL
C5700 mL
D700 mL
4.Med-surg: neuro, endocrine & renalHard
A patient with a cervical spinal cord injury is helped to sit up for the first time. They become dizzy and pale, and the BP falls from 110/70 to 78/46 mmHg. What should the nurse do?
AContinue sitting them upright, because it will pass in an hour
BStand the patient up to improve the blood flow to the legs
CLower the patient back towards lying, then raise them gradually later
DGive a large meal and a strong coffee to raise the blood pressure
5.Med-surg: GI, perioperative & oncologyMedium
How should pancreatic enzyme replacement capsules usually be taken?
AOnly on days with abdominal pain
BWith every meal and snack
COnce a day at bedtime
DOne hour after meals, on an empty stomach
6.Med-surg: GI, perioperative & oncologyHard
A few hours after an ERCP, a patient has severe epigastric pain radiating to the back, with vomiting. Which complication is most likely?
AHepatitis B infection
BPost-ERCP pancreatitis
CAcute appendicitis
DBiliary colic from a new stone
7.Clinical nursingMedium
What should the nurse regularly check for a patient with a syringe driver?
AThe infusion site, the rate and volume remaining, and the patient's symptoms
BOnly that the battery is charged and the device is switched on
CNothing, once the syringe driver is running
DOnly the patient's weight, measured once a week on the same scales
8.Clinical nursingHard
Which patient should a ward nurse assess first at the start of a shift?
AA patient asking for a laxative
BA patient with chronic back pain scored 4/10
CA patient awaiting discharge with stable observations
DA patient with new-onset confusion and a respiratory rate of 28/min
9.Lab values & electrolytesMedium
A 55-year-old has a positive fecal immunochemical test (FIT) during routine screening. What is the usual next step?
AReferral for colonoscopy
BStart an iron supplement only
CNo action if there are no symptoms
DRepeat the test in 10 years
10.Lab values & electrolytesHard
A patient with heart failure has a BNP that was very high on admission and is now falling after diuretic treatment. What does this most likely show?
AWorsening heart failure that needs more fluids
BNew kidney failure caused by the diuretic
CLess stretch on the heart, consistent with improvement
DThat the diuretic must be stopped at once
11.Arterial blood gas interpretationMedium
A practice arterial blood gas shows pH 7.36, PaCO₂ 20 mmHg (2.7 kPa) and HCO₃⁻ 11 mmol/L. The primary disorder is metabolic acidosis. How far is it compensated? Click your answer.
pH 7.36PaCO₂ 20 mmHg (2.7 kPa)HCO₃⁻ 11 mmol/L
1uncompensated
2partially compensated
3fully compensated
12.Arterial blood gas interpretationHard
Practice values: Na⁺ 140, Cl⁻ 111, HCO₃⁻ 17 mmol/L and albumin 29 g/L. Find the albumin-corrected anion gap AGc = AG + 0.25·(40 − albumin).
Measure the QT interval and the R–R interval on this regular lead II strip, then calculate the rate-corrected QTc with Bazett’s formula QTc = QT/√RR (both in seconds). Give the answer in seconds to three decimals.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
QTc = s
14.ECG rhythm strip interpretationHard
Identify the rhythm on this lead II strip. Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1supraventricular tachycardia (SVT)
2torsades de pointes
3idioventricular rhythm
4ventricular fibrillation
15.Prioritization & delegationMedium
Which patient on an addiction unit should the nurse see first?
ALast drink two days ago; now shaking, sweating, heart rate 124/min and seeing insects
BIn recovery for a year; came to the clinic today for a routine check and a repeat prescription
CLast drink one week ago; asking about support groups
DLast drink this morning; asking when lunch will arrive
16.Prioritization & delegationHard
A visitor on the ward becomes threatening and shows a knife. What is the nurse’s priority?
AMove away to safety, keep others away and call security or the police
BIgnore the visitor and carry on with patient care
CArgue with the visitor to persuade them to leave
DTry to take the knife away from the visitor straight away before anyone is hurt
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: D · Ambulatory or structured home blood pressure monitoring
Why this is the answer
"White-coat" hypertension means raised readings only in clinical settings. Ambulatory monitoring over 24 hours or a structured series of home readings gives a truer picture and is widely recommended before diagnosing hypertension.
Answer
D · Ambulatory or structured home blood pressure monitoring
2.Med-surg: cardiovascular & respiratory
Answer: D · Call for urgent help, assess ABCDE and attach a cardiac monitor
Why this is the answer
Beta-blockers and rate-limiting calcium channel blockers have additive effects on the sinus and AV nodes. Symptomatic bradycardia with hypotension is an emergency: call for help, monitor, hold the drugs and anticipate atropine and possibly pacing according to the bradycardia algorithm.
Answer
D · Call for urgent help, assess ABCDE and attach a cardiac monitor
3.Med-surg: neuro, endocrine & renal
Answer: D · 700 mL
Why this is the answer
True urine output equals total drainage minus irrigation volume: 3200 − 2500 = 700 mL. If drainage is less than the irrigant volume, the catheter may be blocked and fluid is being retained.
Answer
D · 700 mL
4.Med-surg: neuro, endocrine & renal
Answer: C · Lower the patient back towards lying, then raise them gradually later
Why this is the answer
Loss of sympathetic tone causes orthostatic hypotension after high spinal injuries. The patient is reclined, and later raised gradually, often with compression stockings, an abdominal binder and sometimes medicines.
Answer
C · Lower the patient back towards lying, then raise them gradually later
5.Med-surg: GI, perioperative & oncology
Answer: B · With every meal and snack
Why this is the answer
Pancreatic enzymes digest fat, protein and carbohydrate, so they are taken with meals and snacks. The dose is adjusted to reduce steatorrhoea and support weight gain.
Answer
B · With every meal and snack
6.Med-surg: GI, perioperative & oncology
Answer: B · Post-ERCP pancreatitis
Why this is the answer
Pancreatitis is the most common serious complication of ERCP. Severe epigastric pain radiating to the back with raised amylase or lipase suggests it; management includes analgesia, IV fluids and close monitoring.
Answer
B · Post-ERCP pancreatitis
7.Clinical nursing
Answer: A · The infusion site, the rate and volume remaining, and the patient's symptoms
Why this is the answer
Nurses check that the infusion is running as planned, the site has no redness or swelling, and the symptoms are controlled. Problems are acted on quickly to avoid distress.
Answer
A · The infusion site, the rate and volume remaining, and the patient's symptoms
8.Clinical nursing
Answer: D · A patient with new-onset confusion and a respiratory rate of 28/min
Why this is the answer
New confusion with tachypnoea suggests acute deterioration, such as sepsis or hypoxia. Patients with stable chronic problems can wait.
Answer
D · A patient with new-onset confusion and a respiratory rate of 28/min
9.Lab values & electrolytes
Answer: A · Referral for colonoscopy
Why this is the answer
A positive FIT means hidden blood in the stool, which may come from a polyp, cancer or other lesion, so a colonoscopy is needed to find the source. A positive screening test is never ignored, even without symptoms.Checked against:Fecal Occult Blood Test (FOBT) · MedlinePlus (NIH) (2024)
Answer
A · Referral for colonoscopy
10.Lab values & electrolytes
Answer: C · Less stretch on the heart, consistent with improvement
Why this is the answer
A falling BNP means the ventricles are under less strain, which fits an improving fluid status. It is read together with symptoms, weight and examination.Checked against:Natriuretic Peptide Tests (BNP, NT-proBNP) · MedlinePlus (NIH) (2023); Brain natriuretic peptide test · MedlinePlus (NIH) (2024)
Answer
C · Less stretch on the heart, consistent with improvement
11.Arterial blood gas interpretation
Answer: fully compensated
Reading a blood gas (ROME): first the pH: below 7.35 is acidaemia, above 7.45 alkalaemia. Then find the value that explains it. PaCO₂ (normal 35–45 mmHg, 4.7–6.0 kPa) is the respiratory part and moves Opposite to the pH in a respiratory disorder; HCO₃⁻ (normal 22–26 mmol/L) is the metabolic part and moves in the same direction as the pH (Respiratory Opposite, Metabolic Equal). The other value shows the compensation: normal means uncompensated; abnormal in the direction that pulls the pH back while the pH is still abnormal means partially compensated; a normal pH with both values abnormal means fully compensated. Ranges differ slightly between laboratories; these are practice values.
ROME, value by value
pH 7.36: within 7.35–7.45
PaCO₂ 20 mmHg: low (35–45)
HCO₃⁻ 11 mmol/L: low (22–26)
Compensation
Clinically, also check the expected compensation: Winter’s formula expects PaCO₂ 22.5–26.5 mmHg, so the measured 20 mmHg points to an additional respiratory alkalosis (a mixed disorder). The answer above is the ROME exam classification.
fully compensated
Answer
fully compensated
12.Arterial blood gas interpretation
Answer: AGc = 14.75 mmol/L
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Anion gap
AG = 140 − (111 + 17) = 12
Correction for albumin
12 + 0.25·(40 − 29) = 14.75 mmol/L
Answer
AGc = 14.75 mmol/L
Above about 12 after correction: a high anion gap.
13.ECG rhythm strip interpretation
Answer: QTc = 0.384 s
QT and QTc: the QT interval runs from the start of the QRS complex to the end of the T wave. It shortens as the heart rate rises, so it is corrected for rate with the R–R interval in seconds: Bazett QTc = QT/√RR and Fridericia QTc = QT/∛RR. Bazett is the formula most textbooks use; it over-corrects at fast rates, where Fridericia is preferred. Limits differ between references: a QTc above about 0.45 s in men or 0.46 s in women is usually called prolonged, and above 0.50 s markedly prolonged.
Measure
QT = 9 × 0.04 = 0.36 s
RR = 22 × 0.04 = 0.88 s
Bazett’s formula
QTc = 0.36/√0.88 = 0.36/0.9381 = 0.384 s
Answer
QTc = 0.384 s
Within the usual limits (about 0.45 s for men, 0.46 s for women). (384 ms)
14.ECG rhythm strip interpretation
Answer: torsades de pointes
More ventricular rhythms: torsades de pointes is a polymorphic ventricular tachycardia, usually 150–250/min, in which the wide complexes change in height and twist around the baseline, pointing up for a few beats and then down. Textbooks link it to a prolonged QT interval, and magnesium sulfate is the drug resuscitation guidelines name for it. An idioventricular rhythm is a ventricular escape rhythm: regular, wide QRS (0.12 s or more), no P waves, at 20–40/min (an accelerated idioventricular rhythm runs at 40–100/min). Monomorphic VT has identical wide complexes at more than 100/min. VF is chaotic, without any repeating complex.
Five steps
1. Rate: very fast, the complexes are about 6 small boxes apart (about 250 per minute).
2. Rhythm: fast and roughly regular, but the height and direction of the complexes change in a repeating spindle pattern.
3. P waves: none identifiable.
4. PR interval: not measurable.
5. QRS: wide and polymorphic; the complexes twist around the baseline, pointing up for a few beats and then down.
Interpretation
torsades de pointes
Answer
torsades de pointes
Torsades de pointes is a polymorphic VT linked to a prolonged QT interval. This is identification practice only.
15.Prioritization & delegation
Answer: A · Last drink two days ago; now shaking, sweating, heart rate 124/min and seeing insects
Why this is the answer
Hallucinations, tremor, sweating and tachycardia two to three days after the last drink suggest severe withdrawal and possible delirium tremens, which can be fatal. This patient needs prompt assessment and treatment.
Answer
A · Last drink two days ago; now shaking, sweating, heart rate 124/min and seeing insects
16.Prioritization & delegation
Answer: A · Move away to safety, keep others away and call security or the police
Why this is the answer
In a threat involving a weapon, staff keep a safe distance, protect patients where possible and call security or the police. Trying to disarm the person puts staff at serious risk.
Answer
A · Move away to safety, keep others away and call security or the police