Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
After repair of an abdominal aortic aneurysm, which regular assessment helps detect a blocked graft or clots in the legs?
ATesting the gag reflex every four hours after surgery
BChecking the pupils' response to light
CChecking leg pulses, colour, warmth and sensation
DMeasuring the blood glucose every hour through the night
2.Med-surg: cardiovascular & respiratoryHard
An older patient with three rib fractures is breathing shallowly and refuses to cough because of pain. What is the priority intervention?
AStrap the chest tightly with bandages to stop the ribs moving
BKeep the patient flat and still in bed until the pain settles
CEffective analgesia so they can breathe deeply and cough
DWithhold analgesia to avoid depressing breathing
3.Med-surg: neuro, endocrine & renalMedium
Why is all urine strained in a patient with suspected kidney stones?
ATo remove blood clots before testing
BTo measure the urine volume more accurately
CTo catch the stone so it can be analysed
DTo stop the stone from blocking the toilet
4.Med-surg: neuro, endocrine & renalHard
Which patient on a stroke unit is most at risk of falling?
AA patient with a TIA whose symptoms resolved completely yesterday
BA patient with a right-hemisphere stroke who is impulsive and denies having weakness
CA patient with a left-hemisphere stroke who has expressive aphasia and waits for help
DA patient with mild dysarthria who walks steadily with a frame
5.Med-surg: GI, perioperative & oncologyMedium
A nasogastric feeding tube appears blocked. What is usually the first step?
AUse a small 5 mL syringe with firm pressure
BFlush gently with warm water in a 50 mL enteral syringe
CCut the end of the tube to release the blockage inside it
DPush the guidewire back in to clear it
6.Med-surg: GI, perioperative & oncologyHard
A patient taking oral capecitabine reports red, painful, peeling palms and soles. What should the nurse do?
AReassure that it is a sign of an unrelated allergy to washing powder
BAdvise hot soaks for the hands and feet
CReport it; this is hand-foot syndrome and treatment may need changing
DTell the patient to take a double dose next time
7.Clinical nursingMedium
Which signs suggest a blood transfusion reaction in the first minutes?
ASlow, steady rise in haemoglobin over the next day
BFever, chills, back pain and low blood pressure
CMild hunger
DImproved colour and energy
8.Clinical nursingHard
A patient's urine output has been very low for 12 hours and creatinine has risen sharply. Which drug on the chart is most likely to need review?
AA non-steroidal anti-inflammatory drug such as ibuprofen
BParacetamol at usual doses
CAn emollient cream
DA vitamin supplement
9.Lab values & electrolytesMedium
A patient with hyperkalemia is prescribed an oral potassium binder such as patiromer or sodium zirconium cyclosilicate. How does this drug lower potassium?
AIt moves potassium into cells in the next few minutes
BIt binds potassium in the gut so it leaves in the stool
CIt stops the kidneys from absorbing water in the tubules
DIt protects the heart muscle against high potassium levels
10.Lab values & electrolytesHard
At the start of a shift, the nurse reviews four new results. Which patient needs attention first?
APotassium 5.2 mEq/L in a patient with stable chronic kidney disease
BHemoglobin 11.0 g/dL (110 g/L) in a patient with rheumatoid arthritis
CGlucose 180 mg/dL (10 mmol/L) after a meal in a patient with diabetes
DSodium 119 mEq/L in a patient with new confusion and vomiting
11.Arterial blood gas interpretationMedium
A practice gas shows PaCO₂ 77 mmHg (10.3 kPa). Use the rule that in chronic respiratory acidosis HCO₃⁻ rises by 3.5 mmol/L for every 10 mmHg that PaCO₂ is above 40, starting from HCO₃⁻ 24 mmol/L, to find the expected HCO₃⁻.
A practice gas shows a respiratory acidosis: pH 7.29, PaCO₂ 62 mmHg (8.3 kPa), HCO₃⁻ 29 mmol/L. Use the rules ‘HCO₃⁻ rises 1 mmol/L per 10 mmHg (acute) or 3.5 mmol/L per 10 mmHg (chronic)’ to classify it. Click your answer.
pH 7.29PaCO₂ 62 mmHg (8.3 kPa)HCO₃⁻ 29 mmol/L
1acute
2chronic
3acute on chronic
13.ECG rhythm strip interpretationMedium
Measure the QT interval and the R–R interval on this regular lead II strip, then calculate the rate-corrected QTc with Bazett’s formula QTc = QT/√RR (both in seconds). Give the answer in seconds to three decimals.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
QTc = s
14.ECG rhythm strip interpretationHard
This lead II strip shows an AV block, so the atria and the ventricles beat at different rates. Measure the P–P interval and find the atrial rate in beats per minute (1500 method, whole number).
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
atrial rate = bpm
15.Prioritization & delegationMedium
A patient is receiving opioids after surgery. Which finding usually comes before opioid-induced respiratory depression?
AIncreased appetite and thirst
BA sudden rise in pain scores
CIncreasing sleepiness that is hard to rouse
DA rise in blood pressure with flushed cheeks
16.Prioritization & delegationHard
After cardiac surgery, a patient becomes hypotensive with distended neck veins and muffled heart sounds, and chest drain output has suddenly stopped. What should the nurse suspect?
ALeft-sided heart failure
BHypovolemic shock from dehydration
CA blocked urinary catheter
DCardiac tamponade
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: C · Checking leg pulses, colour, warmth and sensation
Why this is the answer
After aortic surgery, distal pulses, skin colour, temperature, capillary refill, movement and sensation are checked often and compared with baseline. Loss of pulses, pallor or pain suggests graft occlusion or emboli and must be reported at once. Urine output is also monitored for renal perfusion.
Answer
C · Checking leg pulses, colour, warmth and sensation
2.Med-surg: cardiovascular & respiratory
Answer: C · Effective analgesia so they can breathe deeply and cough
Why this is the answer
Pain from rib fractures causes shallow breathing and poor coughing, leading to atelectasis and pneumonia, especially in older adults. Good analgesia (sometimes regional blocks), deep breathing, coughing with support and early mobilisation are key. Chest strapping restricts breathing and is not used.
Answer
C · Effective analgesia so they can breathe deeply and cough
3.Med-surg: neuro, endocrine & renal
Answer: C · To catch the stone so it can be analysed
Why this is the answer
A passed stone can be sent for analysis. Its composition guides diet and drug advice to prevent recurrence. Straining also confirms that the stone has passed.
Answer
C · To catch the stone so it can be analysed
4.Med-surg: neuro, endocrine & renal
Answer: B · A patient with a right-hemisphere stroke who is impulsive and denies having weakness
Why this is the answer
Right-hemisphere strokes often cause left-sided neglect, poor judgement, impulsivity and denial of the deficit. These patients may try to get up alone. Patients with left-hemisphere strokes are often more cautious.
Answer
B · A patient with a right-hemisphere stroke who is impulsive and denies having weakness
5.Med-surg: GI, perioperative & oncology
Answer: B · Flush gently with warm water in a 50 mL enteral syringe
Why this is the answer
Gentle flushing with warm water using a 50 mL enteral syringe may clear a blockage. Small syringes and force can rupture the tube, and reinserting a guidewire can perforate the oesophagus.
Answer
B · Flush gently with warm water in a 50 mL enteral syringe
6.Med-surg: GI, perioperative & oncology
Answer: C · Report it; this is hand-foot syndrome and treatment may need changing
Why this is the answer
Palmar-plantar erythrodysaesthesia (hand-foot syndrome) is common with capecitabine and fluorouracil. It is graded and may need a treatment break or dose reduction; emollients and avoiding heat and friction help.
Answer
C · Report it; this is hand-foot syndrome and treatment may need changing
7.Clinical nursing
Answer: B · Fever, chills, back pain and low blood pressure
Why this is the answer
An acute haemolytic or febrile reaction can cause fever, rigors, loin or back pain, breathlessness and hypotension. Stop the transfusion and call for help.
Answer
B · Fever, chills, back pain and low blood pressure
8.Clinical nursing
Answer: A · A non-steroidal anti-inflammatory drug such as ibuprofen
Why this is the answer
In acute kidney injury, nephrotoxic drugs (such as NSAIDs and aminoglycosides) and drugs that reduce renal perfusion (such as ACE inhibitors and diuretics) are reviewed and often stopped.
Answer
A · A non-steroidal anti-inflammatory drug such as ibuprofen
9.Lab values & electrolytes
Answer: B · It binds potassium in the gut so it leaves in the stool
Why this is the answer
Potassium binders exchange potassium in the gut for another ion, so potassium is removed from the body in the stool. They act over hours, so they are not used alone for emergencies; calcium protects the heart, and insulin with glucose shifts potassium into cells quickly.Checked against:High potassium level · MedlinePlus (NIH) (2025)
Answer
B · It binds potassium in the gut so it leaves in the stool
10.Lab values & electrolytes
Answer: D · Sodium 119 mEq/L in a patient with new confusion and vomiting
Why this is the answer
Severe hyponatremia with confusion and vomiting suggests cerebral edema and can progress to seizures and coma. The other results are mildly abnormal and expected for those conditions, so they are less urgent.Checked against:Low blood sodium - Medical Encyclopedia · MedlinePlus (NIH) (2025); Sodium Blood Test · MedlinePlus (NIH) (2024)
Answer
D · Sodium 119 mEq/L in a patient with new confusion and vomiting
11.Arterial blood gas interpretation
Answer: HCO₃⁻ = 36.95 mmol/L
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Change in PaCO₂
|77 − 40| = 37 mmHg → 3.7 × 10 mmHg
Expected HCO₃⁻
HCO₃⁻ = 24 + 3.5·3.7 = 36.95 mmol/L
Answer
HCO₃⁻ = 36.95 mmol/L
12.Arterial blood gas interpretation
Answer: acute on chronic
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Expected HCO₃⁻
acute: 24 + 1·2.2 = 26.2 mmol/L
chronic: 24 + 3.5·2.2 = 31.7 mmol/L
Compare
measured: 29 mmol/L → acute on chronic
Answer
acute on chronic
13.ECG rhythm strip interpretation
Answer: QTc = 0.465 s
QT and QTc: the QT interval runs from the start of the QRS complex to the end of the T wave. It shortens as the heart rate rises, so it is corrected for rate with the R–R interval in seconds: Bazett QTc = QT/√RR and Fridericia QTc = QT/∛RR. Bazett is the formula most textbooks use; it over-corrects at fast rates, where Fridericia is preferred. Limits differ between references: a QTc above about 0.45 s in men or 0.46 s in women is usually called prolonged, and above 0.50 s markedly prolonged.
Measure
QT = 9 × 0.04 = 0.36 s
RR = 15 × 0.04 = 0.60 s
Bazett’s formula
QTc = 0.36/√0.60 = 0.36/0.7746 = 0.465 s
Answer
QTc = 0.465 s
Above the usual limits for both men (about 0.45 s) and women (about 0.46 s): prolonged. (465 ms)
14.ECG rhythm strip interpretation
Answer: atrial rate = 63 bpm
AV blocks: march out the P waves and check which ones are followed by a QRS. First-degree: every P conducted, PR constant and above 0.20 s. Second-degree type I (Mobitz I, Wenckebach): the PR lengthens from beat to beat until one P wave is not conducted, then the cycle starts again (group beating). Second-degree type II (Mobitz II): the PR of the conducted beats stays constant, and P waves are suddenly not conducted; the QRS is often wide. Third-degree (complete) block: P waves and QRS complexes are each regular but independent, the PR varies at random and the atrial rate is faster than the escape rate (junctional 40–60/min with a narrow QRS, ventricular 20–40/min with a wide QRS). A 2:1 block cannot be called type I or type II from one strip.
Atrial rate
P–P = 24 small boxes = 0.96 s → 1500 ÷ 24 = 62.5 ≈ 63 per minute
Ventricular rate
4 QRS complexes in 6 s × 10 = 40 per minute
Answer
atrial rate = 63 bpm
Answer
atrial rate = 63 bpm
Second-degree type I (Wenckebach): 4 P waves for every 3 QRS complexes.
15.Prioritization & delegation
Answer: C · Increasing sleepiness that is hard to rouse
Why this is the answer
Sedation usually increases before breathing slows. Regular sedation checks let the nurse hold the opioid and act before respiratory depression occurs.
Answer
C · Increasing sleepiness that is hard to rouse
16.Prioritization & delegation
Answer: D · Cardiac tamponade
Why this is the answer
Hypotension, distended neck veins and muffled heart sounds suggest fluid compressing the heart. A sudden stop in chest drain output can mean clots are trapping blood around the heart; this is an emergency.