Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
Which patient is most typical of a primary spontaneous pneumothorax?
AA middle-aged woman with high blood pressure
BAn older woman with long-standing heart failure
CA child with a viral sore throat
DA tall, thin young man who smokes
2.Med-surg: cardiovascular & respiratoryHard
A patient with a mechanical mitral valve replacement on warfarin has an INR of 2.2. What should the nurse consider?
AThe INR is in range for every warfarin indication, so no action is needed
BThe INR should be about 1.0 for mechanical valves
CThe INR is dangerously high and the dose must be withheld
DThe INR may be below this patient's higher target, so check it and report
3.Med-surg: neuro, endocrine & renalMedium
After a lumbar discectomy, which finding should the nurse report promptly?
AMild pain at the wound site
BNew weakness or numbness in the legs
CStiffness when getting out of bed
DA dry, intact wound dressing
4.Med-surg: neuro, endocrine & renalHard
A patient with SIADH is taught about a fluid restriction. Which statement shows a need for further teaching?
A"I will report any headaches or confusion."
B"If I feel thirsty, I can drink as much water as I like."
C"I will weigh myself every morning."
D"I will count all drinks, including soup, in my daily total."
5.Med-surg: GI, perioperative & oncologyMedium
Which diet is usually recommended for a patient with cirrhosis and hepatic encephalopathy?
AOnly clear fluids for several weeks
BNormal protein and enough calories, with a late-evening snack
CNo food at all until the confusion settles
DA very low-protein diet for the rest of their life to lower ammonia
6.Med-surg: GI, perioperative & oncologyHard
A patient is booked for a urea breath test for H. pylori. Which medicine should usually be stopped 2 weeks before the test?
ALevothyroxine
BAmlodipine
COmeprazole
DParacetamol (acetaminophen)
7.Clinical nursingMedium
What is the most common cause of hypernatraemia in frail older inpatients?
ANot drinking enough water
BToo much exercise
CTaking too many vitamins
DEating too much salt in one meal
8.Clinical nursingHard
A nurse realises she has given a patient a medicine prescribed for another patient. What should she do first?
AAsk a colleague not to mention it
BGive the patient's own medicine as well to balance it
CWait to see whether any side effects develop
DCheck the patient's condition and inform the doctor
9.Lab values & electrolytesMedium
When several samples are drawn at the same venipuncture, which tubes or bottles are filled first?
ABlood culture bottles
BCoagulation (citrate) tubes
CFluoride (glucose) tubes
DEDTA (complete blood count) tubes
10.Lab values & electrolytesHard
A patient without symptoms has a TSH of 7.5 mIU/L on two occasions with a normal free T4. Which term fits best?
ASubclinical hypothyroidism
BSecondary hypothyroidism
COvert primary hypothyroidism
DSubclinical hyperthyroidism
11.Arterial blood gas interpretationMedium
Practice values: Na⁺ 140 mmol/L, glucose 7.3 mmol/L and urea 3.7 mmol/L. Calculate the serum osmolality Osm = 2·Na⁺ + glucose + urea to the nearest whole number.
Na⁺ 140 mmol/Lglucose 7.3 mmol/Lurea 3.7 mmol/L
Osm = mOsm/kg
12.Arterial blood gas interpretationHard
A practice gas shows a respiratory acidosis: pH 7.27, PaCO₂ 67 mmHg (8.9 kPa), HCO₃⁻ 30 mmol/L. Use the rules ‘HCO₃⁻ rises 1 mmol/L per 10 mmHg (acute) or 3.5 mmol/L per 10 mmHg (chronic)’ to classify it. Click your answer.
pH 7.27PaCO₂ 67 mmHg (8.9 kPa)HCO₃⁻ 30 mmol/L
1acute
2chronic
3acute on chronic
13.ECG rhythm strip interpretationMedium
Measure the QT interval and the R–R interval on this regular lead II strip, then calculate the rate-corrected QTc with Bazett’s formula QTc = QT/√RR (both in seconds). Give the answer in seconds to three decimals.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
QTc = s
14.ECG rhythm strip interpretationHard
Interpret this lead II strip. Which interpretation can you defend from this single strip? Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1third-degree (complete) AV block
2sinus bradycardia
32:1 AV block (type undetermined)
4second-degree AV block type I (Wenckebach)
15.Prioritization & delegationMedium
During labor, the nurse sees the umbilical cord in the vagina after the membranes rupture. What is the first action?
AWait for the next contraction before acting
BAsk the patient to walk around the room to bring the baby lower and speed up labor
CPush the cord back into the uterus
DRelieve pressure on the cord by lifting the presenting part with a gloved hand
16.Prioritization & delegationHard
A patient arrives one hour after the start of stroke symptoms. Which step must happen before a thrombolytic drug can be given?
AA swallow test with a cup of water
BA brain scan to rule out bleeding
CAn echocardiogram to look for clots
DA full lipid profile to check cholesterol
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: D · A tall, thin young man who smokes
Why this is the answer
Primary spontaneous pneumothorax usually occurs in tall, thin young men, often smokers, when small apical blebs rupture. Secondary pneumothorax occurs in people with lung disease such as COPD and tends to be more serious.
Answer
D · A tall, thin young man who smokes
2.Med-surg: cardiovascular & respiratory
Answer: D · The INR may be below this patient's higher target, so check it and report
Why this is the answer
Mechanical heart valves, especially in the mitral position, often need a higher INR target (for example 2.5–3.5, depending on valve type and risk factors). An INR of 2.2 may be subtherapeutic, increasing the risk of valve thrombosis and stroke. The nurse checks the documented target and informs the prescriber. DOACs are not used for mechanical valves.
Answer
D · The INR may be below this patient's higher target, so check it and report
3.Med-surg: neuro, endocrine & renal
Answer: B · New weakness or numbness in the legs
Why this is the answer
New or worsening leg weakness, numbness or problems passing urine may indicate a haematoma or nerve root compression and need urgent review. Mild wound pain and stiffness are expected.
Answer
B · New weakness or numbness in the legs
4.Med-surg: neuro, endocrine & renal
Answer: B · "If I feel thirsty, I can drink as much water as I like."
Why this is the answer
In SIADH, the body keeps too much water. Drinking freely when thirsty would lower the sodium further. All fluids count towards the restriction. Daily weights and reporting neurological symptoms are correct.
Answer
B · "If I feel thirsty, I can drink as much water as I like."
5.Med-surg: GI, perioperative & oncology
Answer: B · Normal protein and enough calories, with a late-evening snack
Why this is the answer
Protein restriction worsens malnutrition and muscle loss and is no longer routinely advised. Adequate protein and energy, small frequent meals and a late-evening snack are recommended.
Answer
B · Normal protein and enough calories, with a late-evening snack
6.Med-surg: GI, perioperative & oncology
Answer: C · Omeprazole
Why this is the answer
PPIs suppress H. pylori and can give false-negative breath or stool tests, so they are usually stopped 2 weeks before. Antibiotics are usually stopped 4 weeks before testing.
Answer
C · Omeprazole
7.Clinical nursing
Answer: A · Not drinking enough water
Why this is the answer
Hypernatraemia usually reflects water deficit, often in patients who are confused, unable to drink independently or losing fluid through fever or diarrhoea. Supporting fluid intake prevents it.
Answer
A · Not drinking enough water
8.Clinical nursing
Answer: D · Check the patient's condition and inform the doctor
Why this is the answer
The first priority is the patient: assess them and inform the prescriber so that any treatment can be given. The error must then be documented, reported and discussed openly with the patient (open disclosure; in the UK, the statutory duty of candour).
Answer
D · Check the patient's condition and inform the doctor
9.Lab values & electrolytes
Answer: A · Blood culture bottles
Why this is the answer
Blood cultures are drawn first to reduce contamination. A standard order of draw then follows (citrate, serum, heparin, EDTA, fluoride), which prevents additives being carried from one tube into the next and distorting results.
Answer
A · Blood culture bottles
10.Lab values & electrolytes
Answer: A · Subclinical hypothyroidism
Why this is the answer
A raised TSH with a normal free T4 is subclinical hypothyroidism; the pituitary is working harder to keep T4 normal. Overt hypothyroidism has a low free T4, and subclinical hyperthyroidism has a low TSH.Checked against:TSH (Thyroid-stimulating hormone) Test · MedlinePlus (NIH) (2024)
Answer
A · Subclinical hypothyroidism
11.Arterial blood gas interpretation
Answer: Osm = 291 mOsm/kg
Derived values: calculated serum osmolality is 2·Na⁺ + glucose + urea with all values in mmol/L (2·Na⁺ + glucose/18 + BUN/2.8 with glucose and BUN in mg/dL); normal is about 275–295 mOsm/kg. The P/F ratio is PaO₂ divided by FiO₂ as a fraction. The alveolar oxygen pressure is PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 mmHg at sea level, and the A–a gradient is PAO₂ − PaO₂.
Calculated osmolality
Osm = 2·140 + 7.3 + 3.7 = 291 ≈ 291 mOsm/kg
Answer
Osm = 291 mOsm/kg
12.Arterial blood gas interpretation
Answer: acute on chronic
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Expected HCO₃⁻
acute: 24 + 1·2.7 = 26.7 mmol/L
chronic: 24 + 3.5·2.7 = 33.45 mmol/L
Compare
measured: 30 mmol/L → acute on chronic
Answer
acute on chronic
13.ECG rhythm strip interpretation
Answer: QTc = 0.528 s
QT and QTc: the QT interval runs from the start of the QRS complex to the end of the T wave. It shortens as the heart rate rises, so it is corrected for rate with the R–R interval in seconds: Bazett QTc = QT/√RR and Fridericia QTc = QT/∛RR. Bazett is the formula most textbooks use; it over-corrects at fast rates, where Fridericia is preferred. Limits differ between references: a QTc above about 0.45 s in men or 0.46 s in women is usually called prolonged, and above 0.50 s markedly prolonged.
Measure
QT = 11.5 × 0.04 = 0.46 s
RR = 19 × 0.04 = 0.76 s
Bazett’s formula
QTc = 0.46/√0.76 = 0.46/0.8718 = 0.528 s
Answer
QTc = 0.528 s
Above 0.50 s: markedly prolonged. (528 ms)
14.ECG rhythm strip interpretation
Answer: 2:1 AV block (type undetermined)
2:1 AV block: with two P waves for every QRS, no two conducted P waves follow each other, so you cannot see whether the PR would lengthen (type I) or stay constant (type II) before a non-conducted P wave. From one strip it is called a 2:1 AV block; a longer strip or a change in the conduction ratio decides the type. A narrow QRS makes type I more likely and a wide QRS type II, but neither proves it.
Five steps
1. Rate: R–R = 40 small boxes, 1500 ÷ 40 ≈ 38 per minute.
2. Rhythm: regular, every R–R is 1.60 s.
3. P waves: upright and regular (P–P 0.80 s, 75 per minute), two for every QRS.
4. PR interval: constant at 0.16 s in the conducted beats.
5. QRS: 0.12 s, wide (0.12 s or more).
Why the type stays open
Every second P wave is not conducted, so no two conducted beats follow each other and a lengthening PR could never show.
2:1 AV block (type undetermined)
Answer
2:1 AV block (type undetermined)
A narrow QRS makes type I more likely and a wide QRS type II, but only a longer strip or a change in the conduction ratio decides.
15.Prioritization & delegation
Answer: D · Relieve pressure on the cord by lifting the presenting part with a gloved hand
Why this is the answer
In cord prolapse, the presenting part can compress the cord and cut off fetal oxygen. The nurse lifts the presenting part off the cord, calls for help and positions the patient (for example knee-chest) while urgent birth is arranged.
Answer
D · Relieve pressure on the cord by lifting the presenting part with a gloved hand
16.Prioritization & delegation
Answer: B · A brain scan to rule out bleeding
Why this is the answer
Thrombolytics dissolve clots and would worsen a hemorrhagic stroke. A brain CT (or MRI) is needed first to rule out bleeding, and it must be done quickly.