Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
A patient with heart failure is comfortable at rest but becomes breathless walking across a room. Which NYHA class fits best?
AClass I
BClass IV
CClass III
DClass II
2.Med-surg: cardiovascular & respiratoryHard
A patient with heart failure on a 1.5 L/day fluid restriction complains of severe thirst. Which measure is most appropriate?
AUnlimited water, because thirst must always be satisfied
BNo fluids at all until the next morning's weight
CSalty snacks to stimulate saliva and relieve dryness
DMouth care, counted ice chips and fluids spread through the day
3.Med-surg: neuro, endocrine & renalMedium
Which group of drugs is a well-known cause of SIADH and hyponatraemia, especially in older people?
APenicillin antibiotics
BProton pump inhibitors
CBulk-forming laxatives
DSSRI antidepressants
4.Med-surg: neuro, endocrine & renalHard
Why may HbA1c be unreliable in a patient with haemolytic anaemia or a recent large blood transfusion?
ABlood transfusions contain large amounts of glucose
BAnaemia always makes the HbA1c very high
CIt depends on how long red blood cells survive in the blood
DThe test only measures the glucose in the plasma, not in the cells
5.Med-surg: GI, perioperative & oncologyMedium
Which is a recognised cause of anaphylaxis during surgery?
AThe patient's own blood from cell salvage
BSterile normal saline
CChlorhexidine skin preparation
DA warmed blanket
6.Med-surg: GI, perioperative & oncologyHard
On day 5 after bowel resection, a patient has a fever, tachycardia and worsening abdominal pain, and the drain contains brown, faeculent fluid. What is most likely?
AAn anastomotic leak
BA normal day 5 recovery
CPostoperative constipation
DA urinary tract infection
7.Clinical nursingMedium
Which group of symptoms suggests hypercalcaemia?
AThirst, constipation, confusion and abdominal pain
BTingling lips, muscle cramps and spasms of the hands and feet
CWeight gain, feeling cold and a slow pulse
DSweating, tremor and sudden hunger
8.Clinical nursingHard
A patient with central chest pain has ST elevation on the 12-lead ECG. What is the main aim of urgent treatment?
AWaiting for the troponin result before taking any action
BRestoring blood flow through the blocked coronary artery quickly
CStrict bed rest for several days before deciding on treatment
DStarting a cholesterol-lowering drug before any other treatment is given
9.Lab values & electrolytesMedium
How does IV calcium gluconate help a patient with severe hyperkalemia?
AIt increases potassium excretion by the kidneys
BIt stabilizes heart cell membranes without lowering potassium
CIt binds potassium in the gut so that it is passed in the stool
DIt moves potassium from the blood into the cells
10.Lab values & electrolytesHard
A patient has taken metformin for 8 years and now has numbness in the feet, a hemoglobin of 10.2 g/dL (102 g/L) and an MCV of 108 fL. Which deficiency is most likely?
AIron deficiency from gut loss
BVitamin K deficiency
CVitamin B12 deficiency
DVitamin D (calciferol) deficiency
11.Arterial blood gas interpretationMedium
A practice arterial blood gas shows pH 7.54, PaCO₂ 39 mmHg (5.2 kPa) and HCO₃⁻ 32 mmol/L. The primary disorder is metabolic alkalosis. How far is it compensated? Click your answer.
pH 7.54PaCO₂ 39 mmHg (5.2 kPa)HCO₃⁻ 32 mmol/L
1uncompensated
2partially compensated
3fully compensated
12.Arterial blood gas interpretationHard
A practice gas shows a metabolic acidosis: pH 7.19, PaCO₂ 43 mmHg (5.7 kPa), HCO₃⁻ 16 mmol/L. Compare the measured PaCO₂ with Winter’s formula. Click your interpretation.
pH 7.19PaCO₂ 43 mmHg (5.7 kPa)HCO₃⁻ 16 mmol/L
1appropriate compensation
2added respiratory acidosis
3added respiratory alkalosis
13.ECG rhythm strip interpretationMedium
Interpret this lead II rhythm strip. Which rhythm is it? Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1junctional rhythm
2sinus tachycardia
3first-degree AV block
4normal sinus rhythm
14.ECG rhythm strip interpretationHard
This lead II strip shows an AV block, so the atria and the ventricles beat at different rates. The QRS complexes are regular: find the ventricular rate in beats per minute (1500 method, whole number).
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
ventricular rate = bpm
15.Prioritization & delegationMedium
Which scheduled medication is the most time-critical?
AA daily multivitamin tablet due at 08:00
BRapid-acting insulin due with a breakfast tray that has arrived
CA daily stool softener due with breakfast
DA daily cholesterol-lowering statin tablet due with breakfast at 08:00
16.Prioritization & delegationHard
After cardiac surgery, a patient becomes hypotensive with distended neck veins and muffled heart sounds, and chest drain output has suddenly stopped. What should the nurse suspect?
AHypovolemic shock from dehydration
BLeft-sided heart failure
CA blocked urinary catheter
DCardiac tamponade
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: C · Class III
Why this is the answer
NYHA class I has no limitation, class II slight limitation with ordinary activity, class III marked limitation with less than ordinary activity but comfortable at rest, and class IV symptoms at rest. The class guides treatment and prognosis.
Answer
C · Class III
2.Med-surg: cardiovascular & respiratory
Answer: D · Mouth care, counted ice chips and fluids spread through the day
Why this is the answer
Spreading fluids through the day, using small cups, sucking ice chips (counted in the total), sugar-free gum and regular mouth care help patients tolerate fluid restriction. Salty foods increase thirst and fluid retention.
Answer
D · Mouth care, counted ice chips and fluids spread through the day
3.Med-surg: neuro, endocrine & renal
Answer: D · SSRI antidepressants
Why this is the answer
SSRIs such as sertraline and citalopram can cause SIADH, particularly in older adults. Carbamazepine, some antipsychotics and some chemotherapy drugs are other causes. Sodium is checked if symptoms appear.
Answer
D · SSRI antidepressants
4.Med-surg: neuro, endocrine & renal
Answer: C · It depends on how long red blood cells survive in the blood
Why this is the answer
HbA1c reflects glucose exposure over the lifespan of red cells. If red cells are destroyed early, or donor cells are added, the result may not match true average glucose. Glucose monitoring or other tests may be used instead.
Answer
C · It depends on how long red blood cells survive in the blood
5.Med-surg: GI, perioperative & oncology
Answer: C · Chlorhexidine skin preparation
Why this is the answer
Common causes of perioperative anaphylaxis include neuromuscular blockers, antibiotics, chlorhexidine and latex. Allergies are documented, and suspected reactions are investigated afterwards.
Answer
C · Chlorhexidine skin preparation
6.Med-surg: GI, perioperative & oncology
Answer: A · An anastomotic leak
Why this is the answer
Leakage at the join in the bowel causes peritonitis and sepsis, usually a few days after surgery. Faeculent drain fluid makes it very likely. It needs urgent surgical review, sepsis care and often return to theatre.
Answer
A · An anastomotic leak
7.Clinical nursing
Answer: A · Thirst, constipation, confusion and abdominal pain
Why this is the answer
High calcium causes polyuria and thirst, constipation, abdominal pain, kidney stones and confusion. Tingling and cramps suggest low calcium instead.
Answer
A · Thirst, constipation, confusion and abdominal pain
8.Clinical nursing
Answer: B · Restoring blood flow through the blocked coronary artery quickly
Why this is the answer
ST-elevation myocardial infarction means a coronary artery is usually completely blocked. Urgent reperfusion by primary PCI, or thrombolysis if PCI is not available in time, limits the amount of heart muscle that dies.
Answer
B · Restoring blood flow through the blocked coronary artery quickly
9.Lab values & electrolytes
Answer: B · It stabilizes heart cell membranes without lowering potassium
Why this is the answer
Calcium counteracts the effect of high potassium on the heart’s electrical activity within minutes. The potassium must still be lowered by shifting it into cells (insulin with glucose) and removing it (binders, diuretics or dialysis).Checked against:High potassium level · MedlinePlus (NIH) (2025)
Answer
B · It stabilizes heart cell membranes without lowering potassium
10.Lab values & electrolytes
Answer: C · Vitamin B12 deficiency
Why this is the answer
Long-term metformin reduces vitamin B12 absorption in the gut. B12 deficiency causes macrocytic anemia and peripheral neuropathy, which can be mistaken for diabetic neuropathy. Periodic B12 testing is recommended for long-term users.Checked against:Vitamin B Test · MedlinePlus (NIH) (2026)
Answer
C · Vitamin B12 deficiency
11.Arterial blood gas interpretation
Answer: uncompensated
Reading a blood gas (ROME): first the pH: below 7.35 is acidaemia, above 7.45 alkalaemia. Then find the value that explains it. PaCO₂ (normal 35–45 mmHg, 4.7–6.0 kPa) is the respiratory part and moves Opposite to the pH in a respiratory disorder; HCO₃⁻ (normal 22–26 mmol/L) is the metabolic part and moves in the same direction as the pH (Respiratory Opposite, Metabolic Equal). The other value shows the compensation: normal means uncompensated; abnormal in the direction that pulls the pH back while the pH is still abnormal means partially compensated; a normal pH with both values abnormal means fully compensated. Ranges differ slightly between laboratories; these are practice values.
ROME, value by value
pH 7.54: alkalaemia (above 7.45)
PaCO₂ 39 mmHg: normal (35–45)
HCO₃⁻ 32 mmol/L: high (22–26)
Compensation
Clinically, also check the expected compensation: for a metabolic alkalosis PaCO₂ ≈ 0.7·HCO₃⁻ + 21 = 41.4–45.4 mmHg, so the measured 39 mmHg points to an additional respiratory alkalosis (a mixed disorder). The answer above is the ROME exam classification.
uncompensated
Answer
uncompensated
12.Arterial blood gas interpretation
Answer: added respiratory acidosis
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Expected PaCO₂
1.5·16 + 8 = 32 → 30–34 mmHg
Compare
measured: 43 mmHg → added respiratory acidosis
Answer
added respiratory acidosis
13.ECG rhythm strip interpretation
Answer: first-degree AV block
Rhythm criteria (lead II): sinus rhythm has an upright P wave before every QRS, a constant PR of 0.12–0.20 s and a narrow QRS: normal sinus rhythm at 60–100/min, sinus bradycardia below 60, sinus tachycardia above 100. Atrial fibrillation: no P waves, a fibrillatory baseline and an irregularly irregular R–R. Atrial flutter: sawtooth flutter waves at about 250–350/min with a fixed conduction ratio such as 2:1 or 4:1. First-degree AV block: sinus rhythm with a constant PR above 0.20 s. Junctional rhythm: narrow QRS at 40–60/min with absent or inverted P waves (PR below 0.12 s, or P after the QRS). A PVC is an early, wide (0.12 s or more), bizarre QRS without a P wave, with the T wave in the opposite direction and usually a full compensatory pause; in bigeminy every second beat is a PVC.
Five steps
1. Rate: R–R = 25 small boxes, 1500 ÷ 25 ≈ 60 per minute.
2. Rhythm: regular, every R–R is 1.00 s.
3. P waves: upright, one before every QRS, all alike.
4. PR interval: 0.28 s, constant, longer than 0.20 s.
5. QRS: 0.06 s, narrow (below 0.12 s).
Interpretation
first-degree AV block
Answer
first-degree AV block
14.ECG rhythm strip interpretation
Answer: ventricular rate = 33 bpm
AV blocks: march out the P waves and check which ones are followed by a QRS. First-degree: every P conducted, PR constant and above 0.20 s. Second-degree type I (Mobitz I, Wenckebach): the PR lengthens from beat to beat until one P wave is not conducted, then the cycle starts again (group beating). Second-degree type II (Mobitz II): the PR of the conducted beats stays constant, and P waves are suddenly not conducted; the QRS is often wide. Third-degree (complete) block: P waves and QRS complexes are each regular but independent, the PR varies at random and the atrial rate is faster than the escape rate (junctional 40–60/min with a narrow QRS, ventricular 20–40/min with a wide QRS). A 2:1 block cannot be called type I or type II from one strip.
Atrial rate
P–P = 20 small boxes = 0.80 s → 1500 ÷ 20 = 75 ≈ 75 per minute
Ventricular rate
R–R = 46 small boxes = 1.84 s → 1500 ÷ 46 = 32.61 ≈ 33 per minute
Answer
ventricular rate = 33 bpm
Answer
ventricular rate = 33 bpm
Third-degree block with a wide-complex ventricular escape (usually 20–40 per minute).
15.Prioritization & delegation
Answer: B · Rapid-acting insulin due with a breakfast tray that has arrived
Why this is the answer
Rapid-acting insulin is given with a meal; giving it late or without food can cause high or low blood glucose. The other daily medicines can be given a little later without harm.
Answer
B · Rapid-acting insulin due with a breakfast tray that has arrived
16.Prioritization & delegation
Answer: D · Cardiac tamponade
Why this is the answer
Hypotension, distended neck veins and muffled heart sounds suggest fluid compressing the heart. A sudden stop in chest drain output can mean clots are trapping blood around the heart; this is an emergency.