Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
Analysis of a pleural effusion shows it is an exudate (high protein and LDH compared with blood). Which cause is most likely?
AHeart failure with raised venous pressure
BLiver cirrhosis with a low albumin
CNephrotic syndrome with protein lost in urine
DPneumonia or cancer affecting the pleura
2.Med-surg: cardiovascular & respiratoryHard
A patient with lung cancer develops swelling of the face and arms, distended neck and chest veins and breathlessness that is worse when bending forward. What is the most likely cause?
ARight-sided heart failure
BA deep vein thrombosis in the leg
CAn allergic reaction to chemotherapy
DSuperior vena cava obstruction
3.Med-surg: neuro, endocrine & renalMedium
A patient is starting nitrofurantoin for a UTI. Which teaching point is correct?
AIt must be taken only once a week
BIt may turn the urine dark yellow or brown
CIt should be taken on an empty stomach with milk
DIt turns the tears and sweat bright orange
4.Med-surg: neuro, endocrine & renalHard
A large pituitary tumour presses on the optic chiasm. Which visual field defect is most typical?
ALoss of the inner half of the field in both eyes
BComplete blindness in one eye only
CLoss of central vision in both eyes
DLoss of the outer half of the field in both eyes
5.Med-surg: GI, perioperative & oncologyMedium
A routine wound swab grows bacteria, but the wound shows no signs of infection. What does this usually mean?
AThe patient needs IV antibiotics straight away, whatever the wound looks like
BThe wound is colonised; antibiotics are not usually needed
CThe wound must be closed with sutures again
DThe swab result means the wound is infected
6.Med-surg: GI, perioperative & oncologyHard
A patient with cirrhosis takes spironolactone and furosemide. Which blood result should the nurse report before the next dose?
ASodium 138 mmol/L
BPotassium 4.2 mmol/L
CPotassium 6.0 mmol/L
DSodium 141 mmol/L
7.Clinical nursingMedium
A confused patient keeps trying to climb out of bed. Why are bed rails not automatically the answer?
ABed rails always make patients more confused, but only during the day
BBed rails stop staff from taking observations
CPatients can be seriously injured climbing over or becoming trapped in rails
DBed rails are illegal in all hospitals and must never be used at all
8.Clinical nursingHard
Shortly after starting a transfusion, a patient becomes breathless, wheezy and hypotensive with facial swelling. What should the nurse do first?
AStop the transfusion, keep IV access and call for urgent help
BGive paracetamol and an antihistamine and continue the transfusion
CFinish the unit quickly so the exposure time is as short as possible
DSlow the transfusion rate and recheck the observations in an hour
9.Lab values & electrolytesMedium
A patient with recurrent gout starts allopurinol. Which laboratory result shows that the treatment is achieving its goal?
AA falling serum uric acid
BA falling serum potassium
CA rising serum calcium
DA rising white cell count
10.Lab values & electrolytesHard
A patient with alcohol use disorder has a potassium of 3.0 mEq/L despite two days of replacement. The magnesium is 0.9 mEq/L. What is the most appropriate next step?
AGive a diuretic to remove the excess magnesium
BDouble the potassium dose and leave the magnesium for later
CStop all electrolyte replacement for 24 hours and recheck
DReplace the magnesium; low magnesium keeps the kidneys losing potassium
11.Arterial blood gas interpretationMedium
A practice gas shows a metabolic acidosis with HCO₃⁻ 8 mmol/L. Use Winter’s formula to find the expected PaCO₂ (the centre of the range) in mmHg.
HCO₃⁻ 8 mmol/L
PaCO₂ = mmHg
12.Arterial blood gas interpretationHard
A practice gas shows a metabolic alkalosis with HCO₃⁻ 46 mmol/L. Use expected PaCO₂ = 0.7·HCO₃⁻ + 21 to find the expected PaCO₂.
HCO₃⁻ 46 mmol/L
PaCO₂ = mmHg
13.ECG rhythm strip interpretationMedium
Measure the QT interval and the R–R interval on this regular lead II strip, then calculate the rate-corrected QTc with Fridericia’s formula QTc = QT/∛RR (both in seconds). Give the answer in seconds to three decimals.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
QTc = s
14.ECG rhythm strip interpretationHard
Identify the rhythm on this lead II strip. Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1torsades de pointes
2ventricular fibrillation
3idioventricular rhythm
4atrial flutter, 2:1 conduction
15.Prioritization & delegationMedium
A patient is receiving continuous tube feeds. Which action best reduces the risk of aspiration?
AIncrease the feed rate so the stomach empties sooner
BKeep the head of the bed raised to at least 30 degrees
CLay the patient flat for an hour after each bag is hung
DTurn the feed off only while the patient is asleep at night
16.Prioritization & delegationHard
During a continuous tube feed, a patient suddenly starts coughing, becomes breathless and the SpO₂ falls. What is the nurse’s first action?
AStop the feed, sit the patient upright and assess breathing
BIncrease the feed rate so that it finishes sooner
CFlush the tube with 50 mL of water, then continue the feed as before
DLie the patient flat so they can rest
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: D · Pneumonia or cancer affecting the pleura
Why this is the answer
Transudates form when hydrostatic or oncotic pressure changes push fluid out of vessels, as in heart failure, cirrhosis and nephrotic syndrome. Exudates form when inflammation or tumour makes the pleura leaky, so protein and LDH are high (Light's criteria). Common causes are pneumonia, cancer, TB and pulmonary embolism.
Answer
D · Pneumonia or cancer affecting the pleura
2.Med-surg: cardiovascular & respiratory
Answer: D · Superior vena cava obstruction
Why this is the answer
A tumour in the mediastinum can compress the superior vena cava, causing swelling of the face, neck and arms, dilated veins on the chest and breathlessness. It is an oncological emergency. The patient is sat upright and given oxygen if hypoxic, and treatment may include a stent, steroids or radiotherapy.
Answer
D · Superior vena cava obstruction
3.Med-surg: neuro, endocrine & renal
Answer: B · It may turn the urine dark yellow or brown
Why this is the answer
Nitrofurantoin can make urine dark yellow or brown, which is harmless. Taking it with food reduces nausea. Patients should report breathlessness, cough or tingling, which are rare but serious effects.
Answer
B · It may turn the urine dark yellow or brown
4.Med-surg: neuro, endocrine & renal
Answer: D · Loss of the outer half of the field in both eyes
Why this is the answer
The chiasm carries crossing fibres from the nasal retinas, which see the temporal (outer) fields. Compression causes a bitemporal hemianopia. Patients may bump into objects at their sides.
Answer
D · Loss of the outer half of the field in both eyes
5.Med-surg: GI, perioperative & oncology
Answer: B · The wound is colonised; antibiotics are not usually needed
Why this is the answer
Bacteria on the surface without clinical signs of infection is colonisation. Antibiotics are guided by clinical signs such as spreading redness, pain, heat, pus or systemic illness, not by a swab alone.
Answer
B · The wound is colonised; antibiotics are not usually needed
6.Med-surg: GI, perioperative & oncology
Answer: C · Potassium 6.0 mmol/L
Why this is the answer
Spironolactone blocks aldosterone and can cause hyperkalaemia, which risks arrhythmias. A potassium of 6.0 mmol/L is above the normal range (about 3.5–5.0) and needs urgent review before further doses.
Answer
C · Potassium 6.0 mmol/L
7.Clinical nursing
Answer: C · Patients can be seriously injured climbing over or becoming trapped in rails
Why this is the answer
Bed rails can cause entrapment or a fall from a greater height. Their use is based on an individual risk assessment; alternatives include a low bed, crash mats and closer observation.
Answer
C · Patients can be seriously injured climbing over or becoming trapped in rails
8.Clinical nursing
Answer: A · Stop the transfusion, keep IV access and call for urgent help
Why this is the answer
Severe transfusion reactions, including anaphylaxis, require immediately stopping the transfusion, keeping venous access, following the ABCDE approach and treating anaphylaxis with IM adrenaline.
Answer
A · Stop the transfusion, keep IV access and call for urgent help
9.Lab values & electrolytes
Answer: A · A falling serum uric acid
Why this is the answer
Allopurinol reduces uric acid production by blocking xanthine oxidase. Over time, a lower serum uric acid reduces gout attacks and dissolves urate crystals. Kidney function is checked, and a rash must be reported because of rare severe skin reactions.Checked against:Gout · StatPearls (NCBI Bookshelf) (2026)
Answer
A · A falling serum uric acid
10.Lab values & electrolytes
Answer: D · Replace the magnesium; low magnesium keeps the kidneys losing potassium
Why this is the answer
Low magnesium makes the kidneys lose potassium, so hypokalemia does not correct until the magnesium is replaced. Both are common in alcohol use disorder.Checked against:Low blood potassium · MedlinePlus (NIH) (2025); Magnesium Blood Test · MedlinePlus (NIH) (2023)
Answer
D · Replace the magnesium; low magnesium keeps the kidneys losing potassium
11.Arterial blood gas interpretation
Answer: PaCO₂ = 20 mmHg
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Winter’s formula
PaCO₂ = 1.5·8 + 8 = 20 mmHg
range: 18–22 mmHg
Answer
PaCO₂ = 20 mmHg
12.Arterial blood gas interpretation
Answer: PaCO₂ = 53.2 mmHg
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Expected PaCO₂
0.7·46 + 21 = 53.2 mmHg
Answer
PaCO₂ = 53.2 mmHg
The rise has a limit: PaCO₂ rarely goes above about 55 mmHg from compensation alone.
13.ECG rhythm strip interpretation
Answer: QTc = 0.385 s
QT and QTc: the QT interval runs from the start of the QRS complex to the end of the T wave. It shortens as the heart rate rises, so it is corrected for rate with the R–R interval in seconds: Bazett QTc = QT/√RR and Fridericia QTc = QT/∛RR. Bazett is the formula most textbooks use; it over-corrects at fast rates, where Fridericia is preferred. Limits differ between references: a QTc above about 0.45 s in men or 0.46 s in women is usually called prolonged, and above 0.50 s markedly prolonged.
Measure
QT = 10 × 0.04 = 0.40 s
RR = 28 × 0.04 = 1.12 s
Fridericia’s formula
QTc = 0.40/∛1.12 = 0.40/1.038 = 0.385 s
Answer
QTc = 0.385 s
Within the usual limits (about 0.45 s for men, 0.46 s for women). (385 ms)
14.ECG rhythm strip interpretation
Answer: torsades de pointes
More ventricular rhythms: torsades de pointes is a polymorphic ventricular tachycardia, usually 150–250/min, in which the wide complexes change in height and twist around the baseline, pointing up for a few beats and then down. Textbooks link it to a prolonged QT interval, and magnesium sulfate is the drug resuscitation guidelines name for it. An idioventricular rhythm is a ventricular escape rhythm: regular, wide QRS (0.12 s or more), no P waves, at 20–40/min (an accelerated idioventricular rhythm runs at 40–100/min). Monomorphic VT has identical wide complexes at more than 100/min. VF is chaotic, without any repeating complex.
Five steps
1. Rate: very fast, the complexes are about 6 small boxes apart (about 250 per minute).
2. Rhythm: fast and roughly regular, but the height and direction of the complexes change in a repeating spindle pattern.
3. P waves: none identifiable.
4. PR interval: not measurable.
5. QRS: wide and polymorphic; the complexes twist around the baseline, pointing up for a few beats and then down.
Interpretation
torsades de pointes
Answer
torsades de pointes
Torsades de pointes is a polymorphic VT linked to a prolonged QT interval. This is identification practice only.
15.Prioritization & delegation
Answer: B · Keep the head of the bed raised to at least 30 degrees
Why this is the answer
Raising the head of the bed to at least 30 degrees during and after feeding lowers the risk of reflux and aspiration. Lying flat greatly increases the risk.
Answer
B · Keep the head of the bed raised to at least 30 degrees
16.Prioritization & delegation
Answer: A · Stop the feed, sit the patient upright and assess breathing
Why this is the answer
Coughing, breathlessness and a falling saturation during tube feeding suggest aspiration or a displaced tube. The feed is stopped at once, the patient is sat upright, the airway and breathing are assessed, suction and oxygen are used as needed and the provider is informed. Tube position is checked before any feed restarts.
Answer
A · Stop the feed, sit the patient upright and assess breathing