Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
How is a patient usually positioned for a thoracentesis?
AFlat on the back with the legs raised
BLying on the affected side with the head down
CSitting upright and leaning forward over a table
DProne with the arms by the sides
2.Med-surg: cardiovascular & respiratoryHard
Three weeks after a myocardial infarction, a patient has fever, pleuritic chest pain that eases on leaning forward and a pericardial friction rub. Which condition is most likely?
AAcute aortic dissection
BAcute left ventricular failure
CA new STEMI in another artery
DPost-MI (Dressler's) syndrome
3.Med-surg: neuro, endocrine & renalMedium
The day after a thyroidectomy, a patient reports tingling around the mouth and in the fingers. Why might this happen?
AThe thyroid hormone level has risen too high after surgery
BThe anaesthetic has caused an allergic reaction
CThe parathyroid glands may have been damaged, lowering calcium
DThe patient is breathing too slowly after the operation
4.Med-surg: neuro, endocrine & renalHard
A man who takes tamsulosin for BPH is listed for cataract surgery. Which statement is correct?
AThe eye surgeon must be told, as it can cause floppy iris during surgery
BThe dose should be doubled before surgery to prevent urinary retention
CIt should be swapped for oxybutynin the night before to protect the eye
DTamsulosin has no effects outside the urinary tract, so nothing changes
5.Med-surg: GI, perioperative & oncologyMedium
A patient is starting regular oral morphine. Which bowel advice is most appropriate?
AWait until there has been no stool for a week
BTake a bulk-forming laxative only with very little water
CStart a regular laxative at the same time
DStop eating fibre completely
6.Med-surg: GI, perioperative & oncologyHard
Which new prescription for a patient with cirrhosis should the nurse question?
ARegular ibuprofen for back pain
BThiamine supplements
CLactulose to keep the bowels open
DSpironolactone for ascites
7.Clinical nursingMedium
Which advice is correct for a patient taking levothyroxine?
AStop taking it once the symptoms improve
BTake it only on days when feeling tired
CTake it with a large meal to avoid nausea and stomach upset
DTake it on an empty stomach, usually before breakfast
8.Clinical nursingHard
After a viral illness, a patient has sharp chest pain that is worse lying flat and eased by sitting forward. What is the most likely cause?
APulmonary oedema
BStable angina
CAortic dissection
DPericarditis
9.Lab values & electrolytesMedium
A tired patient with heavy menstrual periods has a normal hemoglobin and MCV but a ferritin of 8 ng/mL. What does this show?
AVitamin B12 deficiency anemia
BA completely normal iron status
CIron overload from too much iron
DIron deficiency without anemia yet
10.Lab values & electrolytesHard
A middle-aged man has fatigue, joint pain, a raised ALT and new diabetes. His ferritin is very high and his transferrin saturation is above 60%. Which condition is most likely?
AIron-deficiency anemia
BAnemia of chronic disease
CAcute viral hepatitis A
DHereditary hemochromatosis
11.Arterial blood gas interpretationMedium
A practice gas shows a metabolic acidosis with HCO₃⁻ 10 mmol/L. Use Winter’s formula to find the expected PaCO₂ (the centre of the range) in mmHg.
HCO₃⁻ 10 mmol/L
PaCO₂ = mmHg
12.Arterial blood gas interpretationHard
Practice values: Na⁺ 140, Cl⁻ 96 and HCO₃⁻ 18 mmol/L. Calculate the delta ratio (AG − 12)/(24 − HCO₃⁻), using AG = Na⁺ − (Cl⁻ + HCO₃⁻). Give two decimals.
Na⁺ 140 mmol/LCl⁻ 96 mmol/LHCO₃⁻ 18 mmol/L
delta ratio =
13.ECG rhythm strip interpretationMedium
Measure the QT interval and the R–R interval on this regular lead II strip, then calculate the rate-corrected QTc with Fridericia’s formula QTc = QT/∛RR (both in seconds). Give the answer in seconds to three decimals.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
QTc = s
14.ECG rhythm strip interpretationHard
This patient has a pacemaker. Interpret the lead II strip. Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1idioventricular rhythm
2second-degree AV block type II
3paced rhythm, failure to capture
4dual-chamber (AV) paced rhythm
15.Prioritization & delegationMedium
A patient asks the nursing assistant about the side effects of a new medication. What should the assistant do?
ASay the nurse will come to answer, and tell the nurse
BExplain the side effects listed in the drug’s patient leaflet
CReassure the patient that side effects are rare
DLook the drug up online and read out what it says
16.Prioritization & delegationHard
On a surgical unit, which postoperative patient should the nurse see first?
A2 days after hip replacement: pain 5/10 on moving, analgesic given 1 hour ago
B2 days after colostomy formation: stoma moist and pink, small amount of output
CAfter prostate surgery with bladder irrigation: light pink urine, no clots
D6 hours after carotid endarterectomy: neck swelling increasing, says it is hard to swallow
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: C · Sitting upright and leaning forward over a table
Why this is the answer
Sitting upright and leaning forward on a bedside table widens the intercostal spaces at the back and lets the fluid settle at the base. If the patient cannot sit, lying on the unaffected side may be used.
Answer
C · Sitting upright and leaning forward over a table
2.Med-surg: cardiovascular & respiratory
Answer: D · Post-MI (Dressler's) syndrome
Why this is the answer
Dressler's syndrome is an immune-mediated pericarditis occurring weeks after MI, with fever, pleuritic pain relieved by sitting forward and a friction rub. It is now uncommon in the reperfusion era. A new infarction causes ischaemic pain not changed by posture; dissection causes tearing pain radiating to the back.
Answer
D · Post-MI (Dressler's) syndrome
3.Med-surg: neuro, endocrine & renal
Answer: C · The parathyroid glands may have been damaged, lowering calcium
Why this is the answer
The parathyroid glands lie behind the thyroid and can be damaged or removed during surgery. Low PTH leads to hypocalcaemia, causing tingling, cramps and, if severe, tetany or arrhythmias. Calcium is checked after surgery.
Answer
C · The parathyroid glands may have been damaged, lowering calcium
4.Med-surg: neuro, endocrine & renal
Answer: A · The eye surgeon must be told, as it can cause floppy iris during surgery
Why this is the answer
Tamsulosin blocks alpha-1A receptors in the iris dilator muscle as well as in the prostate, which can cause intraoperative floppy iris syndrome during cataract surgery. The effect can persist after the drug is stopped, so the surgeon must know in advance to plan the operation. Whether to pause it is a decision for the team.
Answer
A · The eye surgeon must be told, as it can cause floppy iris during surgery
5.Med-surg: GI, perioperative & oncology
Answer: C · Start a regular laxative at the same time
Why this is the answer
Opioids slow gut movement, and tolerance to constipation does not develop. A regular laxative, often a stimulant with a softener, is started with the opioid, alongside fluids and mobility where possible.
Answer
C · Start a regular laxative at the same time
6.Med-surg: GI, perioperative & oncology
Answer: A · Regular ibuprofen for back pain
Why this is the answer
NSAIDs can cause kidney injury, fluid retention and GI bleeding in cirrhosis and should be avoided. Paracetamol at a reduced, carefully reviewed dose is usually preferred for pain.
Answer
A · Regular ibuprofen for back pain
7.Clinical nursing
Answer: D · Take it on an empty stomach, usually before breakfast
Why this is the answer
Levothyroxine is absorbed best on an empty stomach and is usually taken at the same time each morning. It is normally lifelong, with doses adjusted by thyroid blood tests.
Answer
D · Take it on an empty stomach, usually before breakfast
8.Clinical nursing
Answer: D · Pericarditis
Why this is the answer
Pericarditis typically causes sharp, positional chest pain relieved by sitting forward, sometimes with a pericardial rub. Viral infection is a common cause.
Answer
D · Pericarditis
9.Lab values & electrolytes
Answer: D · Iron deficiency without anemia yet
Why this is the answer
Iron stores (ferritin) are depleted before the hemoglobin falls. A low ferritin with a normal hemoglobin indicates iron deficiency without anemia, and it is usually treated, along with the cause of blood loss.Checked against:Ferritin Blood Test · MedlinePlus (NIH) (2025); Iron deficiency anemia - Medical Encyclopedia · MedlinePlus (NIH) (2025)
Answer
D · Iron deficiency without anemia yet
10.Lab values & electrolytes
Answer: D · Hereditary hemochromatosis
Why this is the answer
Hemochromatosis is an inherited disorder of increased iron absorption. Iron is deposited in the liver, pancreas, joints, heart and skin. A high transferrin saturation with a high ferritin suggests the diagnosis, and treatment is regular venesection (phlebotomy).Checked against:Hemochromatosis · MedlinePlus (NIH) (2026); Ferritin Blood Test · MedlinePlus (NIH) (2025)
Answer
D · Hereditary hemochromatosis
11.Arterial blood gas interpretation
Answer: PaCO₂ = 23 mmHg
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Winter’s formula
PaCO₂ = 1.5·10 + 8 = 23 mmHg
range: 21–25 mmHg
Answer
PaCO₂ = 23 mmHg
12.Arterial blood gas interpretation
Answer: delta ratio = 2.333
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Anion gap
AG = 140 − (96 + 18) = 26
Delta ratio
(26 − 12)/(24 − 18) = 14/6 = 2.333
Answer
delta ratio = 2.333
Above 2: an added metabolic alkalosis.
13.ECG rhythm strip interpretation
Answer: QTc = 0.466 s
QT and QTc: the QT interval runs from the start of the QRS complex to the end of the T wave. It shortens as the heart rate rises, so it is corrected for rate with the R–R interval in seconds: Bazett QTc = QT/√RR and Fridericia QTc = QT/∛RR. Bazett is the formula most textbooks use; it over-corrects at fast rates, where Fridericia is preferred. Limits differ between references: a QTc above about 0.45 s in men or 0.46 s in women is usually called prolonged, and above 0.50 s markedly prolonged.
Measure
QT = 11 × 0.04 = 0.44 s
RR = 21 × 0.04 = 0.84 s
Fridericia’s formula
QTc = 0.44/∛0.84 = 0.44/0.9435 = 0.466 s
Answer
QTc = 0.466 s
Above the usual limits for both men (about 0.45 s) and women (about 0.46 s): prolonged. (466 ms)
14.ECG rhythm strip interpretation
Answer: paced rhythm, failure to capture
Paced rhythms: a pacemaker impulse shows as a narrow vertical pacing spike. After a ventricular spike the QRS is wide (0.12 s or more), because the impulse spreads from the lead through the muscle instead of the conduction system; with right-ventricular pacing it is often mostly negative in lead II. A spike before each P wave means atrial pacing, and a dual-chamber (AV) pacemaker shows an atrial spike and a P wave, then, after the programmed AV delay, a ventricular spike and a wide QRS. Capture means every spike is followed by a depolarisation. Failure to capture is a spike without a P wave or QRS after it; failure to sense (spikes that ignore the patient’s own beats) and failure to pace (no spike when one is due) are the other classic malfunctions.
Five steps
1. Rate: 6 QRS complexes in 6 s, × 10 = 60 per minute.
2. Rhythm: the pacing spikes are regular (every 0.88 s), but the R–R is not, because a QRS is missing after some spikes.
3. P waves: none visible.
4. PR interval: not measurable.
5. QRS: 0.14 s and wide after the captured spikes; one spike is not followed by a QRS (no capture).
Interpretation
paced rhythm, failure to capture
Answer
paced rhythm, failure to capture
Failure to capture: the pacemaker fires but the heart does not respond. Textbooks treat it as urgent to report, because the patient may depend on the pacemaker.
15.Prioritization & delegation
Answer: A · Say the nurse will come to answer, and tell the nurse
Why this is the answer
Patient teaching about medicines is a nursing responsibility. The assistant passes the question on to the nurse, so the patient gets accurate information that fits their situation.
Answer
A · Say the nurse will come to answer, and tell the nurse
16.Prioritization & delegation
Answer: D · 6 hours after carotid endarterectomy: neck swelling increasing, says it is hard to swallow
Why this is the answer
Growing neck swelling after carotid surgery suggests a hematoma that can compress the airway. A pink, moist stoma and light pink urine with irrigation are expected, and moderate pain with movement is common.
Answer
D · 6 hours after carotid endarterectomy: neck swelling increasing, says it is hard to swallow