Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
A patient taking isosorbide mononitrate asks about sildenafil for erectile dysfunction. What is the main danger?
ASevere hypertension
BSevere hypotension
CA very high potassium level
DBleeding from the gums
2.Med-surg: cardiovascular & respiratoryHard
A patient taking ramipril and indapamide for hypertension starts regular ibuprofen for back pain. A week later, creatinine has risen sharply. What is the most likely cause?
AAn allergic reaction to the diuretic causing inflammation of the kidney
BBack pain causing kidney damage
CAn ACE inhibitor, diuretic and NSAID together reducing kidney perfusion
DIbuprofen raising the blood pressure to levels that damage the kidneys
3.Med-surg: neuro, endocrine & renalMedium
A patient has taken metformin for many years and now has tingling feet and a low haemoglobin. Which blood test is most relevant?
ABlood alcohol level
BSerum amylase
CThyroid antibodies
DVitamin B12 level
4.Med-surg: neuro, endocrine & renalHard
Which of these patients with acute ischaemic stroke is least likely to be eligible for IV thrombolysis?
AA patient whose CT scan shows no sign of any intracranial bleeding
BA patient whose blood pressure is 170/95 mmHg
CA patient whose symptoms began 90 minutes ago
DA patient who had major abdominal surgery five days ago
5.Med-surg: GI, perioperative & oncologyMedium
Dysphagia that started with solids and now includes liquids, with weight loss, most suggests which cause?
AA narrowing such as an oesophageal tumour
BSimple anxiety about swallowing tablets
CA dry mouth from drinking too little water
DNormal ageing of the swallowing muscles
6.Med-surg: GI, perioperative & oncologyHard
A surgical patient's MUST score is 3 and the wound is healing slowly. What is the most appropriate action?
ARestrict protein to help the kidneys
BEncourage fasting to reduce wound exudate and the size of the dressing
CRepeat the score in three months' time
DRefer to the dietitian, start a nutrition plan and monitor intake
7.Clinical nursingMedium
An older adult has left lower abdominal pain, fever and a raised CRP. Which condition is most likely?
AAppendicitis
BBiliary colic
CGastric ulcer
DDiverticulitis
8.Clinical nursingHard
After a viral illness, a patient has sharp chest pain that is worse lying flat and eased by sitting forward. What is the most likely cause?
APericarditis
BAortic dissection
CStable angina
DPulmonary oedema
9.Lab values & electrolytesMedium
A patient receives subcutaneous enoxaparin (a low-molecular-weight heparin). Which statement about monitoring is correct?
AThe INR is used to adjust each dose, as with warfarin
BNo routine aPTT; platelets and kidney function are checked instead
CThe aPTT must be checked every 6 hours to adjust the dose
DNo blood tests of any kind are ever needed
10.Lab values & electrolytesHard
A patient with acute kidney injury has a potassium of 6.8 mEq/L despite medical treatment, a pH of 7.12 and pulmonary edema not responding to diuretics. Which treatment is most likely needed?
AAn IV magnesium dose
BMore oral fluid
CA potassium supplement
DUrgent dialysis
11.Arterial blood gas interpretationMedium
Practice values: Na⁺ 151 mmol/L, glucose 5 mmol/L and urea 5.6 mmol/L. Calculate the serum osmolality Osm = 2·Na⁺ + glucose + urea to the nearest whole number.
Na⁺ 151 mmol/Lglucose 5 mmol/Lurea 5.6 mmol/L
Osm = mOsm/kg
12.Arterial blood gas interpretationHard
Practice values: Na⁺ 138, Cl⁻ 107, HCO₃⁻ 17 mmol/L and albumin 37 g/L. Find the albumin-corrected anion gap AGc = AG + 0.25·(40 − albumin).
Interpret this lead II rhythm strip. Which rhythm is it? Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1normal sinus rhythm
2junctional rhythm
3first-degree AV block
4sinus bradycardia
14.ECG rhythm strip interpretationHard
This patient has a pacemaker. Interpret the lead II strip. Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1idioventricular rhythm
2sinus rhythm with wide QRS
3dual-chamber (AV) paced rhythm
4third-degree (complete) AV block
15.Prioritization & delegationMedium
A cardiac monitor shows a flat line (asystole) for a patient, but the patient is sitting up and talking. What does the nurse do first?
ACall the cardiac arrest team
BCheck the patient and the electrode leads
CStart chest compressions at once
DPrepare the defibrillator to deliver a shock
16.Prioritization & delegationHard
On an addiction unit, which patient should the nurse assess first?
AAnxious, with goose bumps, stomach cramps and loose stools
BAsking for an extra blanket and a hot drink
CYawning, with a runny nose and dilated pupils
DDrowsy with pinpoint pupils and a respiratory rate of 7/min
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: B · Severe hypotension
Why this is the answer
Phosphodiesterase-5 inhibitors such as sildenafil enhance the vasodilator effect of nitrates and can cause profound, life-threatening hypotension. The combination is contraindicated, and patients should tell emergency staff if they have taken one.
Answer
B · Severe hypotension
2.Med-surg: cardiovascular & respiratory
Answer: C · An ACE inhibitor, diuretic and NSAID together reducing kidney perfusion
Why this is the answer
NSAIDs constrict the afferent arteriole, ACE inhibitors dilate the efferent arteriole and diuretics reduce volume. Together (sometimes called the "triple whammy") they can cause acute kidney injury. The NSAID is stopped, and the prescriber reviews the other drugs.
Answer
C · An ACE inhibitor, diuretic and NSAID together reducing kidney perfusion
3.Med-surg: neuro, endocrine & renal
Answer: D · Vitamin B12 level
Why this is the answer
Long-term metformin can lower vitamin B12 absorption, causing anaemia and neuropathy that may be mistaken for diabetic neuropathy. B12 levels are checked, especially when symptoms appear.
Answer
D · Vitamin B12 level
4.Med-surg: neuro, endocrine & renal
Answer: D · A patient who had major abdominal surgery five days ago
Why this is the answer
Recent major surgery (within roughly 14 days in many guidelines) greatly increases the bleeding risk and is a contraindication to thrombolysis. Onset within 4.5 hours, a blood pressure below 185/110 mmHg and a CT without haemorrhage are conditions that permit it.
Answer
D · A patient who had major abdominal surgery five days ago
5.Med-surg: GI, perioperative & oncology
Answer: A · A narrowing such as an oesophageal tumour
Why this is the answer
Progressive dysphagia, solids first then liquids, with weight loss, is typical of a mechanical obstruction such as oesophageal cancer or a stricture. It needs an urgent referral for endoscopy.
Answer
A · A narrowing such as an oesophageal tumour
6.Med-surg: GI, perioperative & oncology
Answer: D · Refer to the dietitian, start a nutrition plan and monitor intake
Why this is the answer
A MUST score of 2 or more indicates high risk of malnutrition. Poor nutrition delays healing, so the nurse refers to the dietitian, starts a care plan with food charts and supplements as advised, and rescreens regularly.
Answer
D · Refer to the dietitian, start a nutrition plan and monitor intake
7.Clinical nursing
Answer: D · Diverticulitis
Why this is the answer
Diverticulitis is inflammation of diverticula, usually in the sigmoid colon, so pain is typically in the left iliac fossa. It is common in older adults.
Answer
D · Diverticulitis
8.Clinical nursing
Answer: A · Pericarditis
Why this is the answer
Pericarditis typically causes sharp, positional chest pain relieved by sitting forward, sometimes with a pericardial rub. Viral infection is a common cause.
Answer
A · Pericarditis
9.Lab values & electrolytes
Answer: B · No routine aPTT; platelets and kidney function are checked instead
Why this is the answer
Enoxaparin has a predictable effect, so the aPTT is not used to monitor it. Platelet counts help detect heparin-induced thrombocytopenia, and kidney function matters because the drug is cleared by the kidneys. Anti-Xa levels may be used in pregnancy, obesity or kidney disease.
Answer
B · No routine aPTT; platelets and kidney function are checked instead
10.Lab values & electrolytes
Answer: D · Urgent dialysis
Why this is the answer
Indications for urgent dialysis in AKI include refractory hyperkalemia, severe metabolic acidosis, fluid overload not responding to diuretics, uremic complications and some poisonings. This patient has three of them.Checked against:Acute tubular necrosis · MedlinePlus (NIH) (2025)
Answer
D · Urgent dialysis
11.Arterial blood gas interpretation
Answer: Osm = 313 mOsm/kg
Derived values: calculated serum osmolality is 2·Na⁺ + glucose + urea with all values in mmol/L (2·Na⁺ + glucose/18 + BUN/2.8 with glucose and BUN in mg/dL); normal is about 275–295 mOsm/kg. The P/F ratio is PaO₂ divided by FiO₂ as a fraction. The alveolar oxygen pressure is PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 mmHg at sea level, and the A–a gradient is PAO₂ − PaO₂.
Calculated osmolality
Osm = 2·151 + 5 + 5.6 = 312.6 ≈ 313 mOsm/kg
Answer
Osm = 313 mOsm/kg
12.Arterial blood gas interpretation
Answer: AGc = 14.75 mmol/L
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Anion gap
AG = 138 − (107 + 17) = 14
Correction for albumin
14 + 0.25·(40 − 37) = 14.75 mmol/L
Answer
AGc = 14.75 mmol/L
Above about 12 after correction: a high anion gap.
13.ECG rhythm strip interpretation
Answer: first-degree AV block
Rhythm criteria (lead II): sinus rhythm has an upright P wave before every QRS, a constant PR of 0.12–0.20 s and a narrow QRS: normal sinus rhythm at 60–100/min, sinus bradycardia below 60, sinus tachycardia above 100. Atrial fibrillation: no P waves, a fibrillatory baseline and an irregularly irregular R–R. Atrial flutter: sawtooth flutter waves at about 250–350/min with a fixed conduction ratio such as 2:1 or 4:1. First-degree AV block: sinus rhythm with a constant PR above 0.20 s. Junctional rhythm: narrow QRS at 40–60/min with absent or inverted P waves (PR below 0.12 s, or P after the QRS). A PVC is an early, wide (0.12 s or more), bizarre QRS without a P wave, with the T wave in the opposite direction and usually a full compensatory pause; in bigeminy every second beat is a PVC.
Five steps
1. Rate: R–R = 22 small boxes, 1500 ÷ 22 ≈ 68 per minute.
2. Rhythm: regular, every R–R is 0.88 s.
3. P waves: upright, one before every QRS, all alike.
4. PR interval: 0.26 s, constant, longer than 0.20 s.
5. QRS: 0.10 s, narrow (below 0.12 s).
Interpretation
first-degree AV block
Answer
first-degree AV block
14.ECG rhythm strip interpretation
Answer: dual-chamber (AV) paced rhythm
Paced rhythms: a pacemaker impulse shows as a narrow vertical pacing spike. After a ventricular spike the QRS is wide (0.12 s or more), because the impulse spreads from the lead through the muscle instead of the conduction system; with right-ventricular pacing it is often mostly negative in lead II. A spike before each P wave means atrial pacing, and a dual-chamber (AV) pacemaker shows an atrial spike and a P wave, then, after the programmed AV delay, a ventricular spike and a wide QRS. Capture means every spike is followed by a depolarisation. Failure to capture is a spike without a P wave or QRS after it; failure to sense (spikes that ignore the patient’s own beats) and failure to pace (no spike when one is due) are the other classic malfunctions.
Five steps
1. Rate: R–R = 25 small boxes, 1500 ÷ 25 ≈ 60 per minute.
2. Rhythm: regular, every R–R is 1.00 s.
3. P waves: each P wave follows its own pacing spike (atrial pacing).
4. AV interval: the second spike comes 0.20 s after the first one (the programmed AV delay).
5. QRS: 0.14 s, wide, right after the second spike (ventricular pacing).
Interpretation
dual-chamber (AV) paced rhythm
Answer
dual-chamber (AV) paced rhythm
The paced QRS is wide by nature; do not call it a bundle branch block or a ventricular rhythm.
15.Prioritization & delegation
Answer: B · Check the patient and the electrode leads
Why this is the answer
A talking patient has a pulse, so the flat line is almost certainly a lead or electrode problem. The nurse assesses the patient and fixes the leads. CPR and defibrillation are for patients who are actually in arrest.
Answer
B · Check the patient and the electrode leads
16.Prioritization & delegation
Answer: D · Drowsy with pinpoint pupils and a respiratory rate of 7/min
Why this is the answer
Pinpoint pupils, drowsiness and slow breathing suggest opioid overdose, which can be fatal. Yawning, a runny nose, dilated pupils and cramps are signs of opioid withdrawal, which is distressing but rarely life-threatening.
Answer
D · Drowsy with pinpoint pupils and a respiratory rate of 7/min