Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
A patient with peripheral arterial disease has leg pain at night. Which position may ease it?
AWrapping the legs in compression bandages
BRaising the legs on pillows above heart level
CApplying a hot water bottle directly to the feet
DHanging the legs down over the side of the bed
2.Med-surg: cardiovascular & respiratoryHard
A patient on warfarin for atrial fibrillation has an INR of 8.5 but no bleeding. What is the most likely management?
AWithhold warfarin, inform the prescriber and recheck the INR soon
BGive IV protamine sulfate immediately to reverse it
CContinue the usual dose and recheck the INR in a month
DGive prothrombin complex concentrate and a blood transfusion
3.Med-surg: neuro, endocrine & renalMedium
In the first trimester of pregnancy, why is propylthiouracil often preferred to carbimazole for hyperthyroidism?
ACarbimazole cannot cross into the mother's blood
BPropylthiouracil has no side effects at all
CPropylthiouracil works faster than any other drug
DCarbimazole has a higher risk of birth defects early on
4.Med-surg: neuro, endocrine & renalHard
A patient on levothyroxine has palpitations, weight loss and poor sleep. TSH is suppressed, and free T4 is high. What is the most likely explanation?
AThe dose is too high
BThe thyroid has stopped working
CA normal response to the drug
DThe dose is too low
5.Med-surg: GI, perioperative & oncologyMedium
How are skin staples usually removed from a healed incision?
AOnly the staples at each end, leaving the others for good
BAll staples at once by pulling each one straight up from the skin
CThe staples are left in permanently under the skin
DAlternate staples first, then the rest if the wound holds
6.Med-surg: GI, perioperative & oncologyHard
A 76-year-old with a past peptic ulcer needs long-term anti-inflammatory treatment for arthritis. Which plan best reduces GI bleeding risk?
ACombine two different NSAIDs at lower doses
BTake the NSAID with a glass of milk instead of food
CUse the highest NSAID dose to shorten the course
DConsider an alternative; if an NSAID is needed, add a PPI
7.Clinical nursingMedium
Which lifestyle advice helps a patient with gastro-oesophageal reflux disease?
ALie down straight after each meal to let the food settle
BWear tight belts to support the stomach
CAvoid large meals late in the evening and raise the head of the bed
DEat one very large meal a day rather than several small ones
8.Clinical nursingHard
A patient has a single hot, swollen, very painful knee and a fever. Why is urgent joint aspiration important?
ATo measure the patient's cholesterol
BTo prevent osteoporosis
CTo rule out septic arthritis, which can rapidly destroy the joint
DTo check for rheumatoid arthritis antibodies in the joint fluid
9.Lab values & electrolytesMedium
A nurse completed the hepatitis B vaccine series. Which result shows protective immunity?
AA raised ALT level
BAnti-HBs of 10 mIU/mL or more
CA positive HBsAg test
DA positive IgM anti-HBc
10.Lab values & electrolytesHard
After surgery, a patient receiving large volumes of hypotonic IV fluid develops headache, nausea and confusion. Which result best explains this?
AA calcium of 9.4 mg/dL (2.35 mmol/L)
BA potassium of 4.2 mEq/L
CA glucose of 110 mg/dL (6.1 mmol/L)
DA sodium of 126 mEq/L
11.Arterial blood gas interpretationMedium
A practice arterial blood gas shows pH 7.14, PaCO₂ 73 mmHg (9.7 kPa) and HCO₃⁻ 24 mmol/L. The primary disorder is respiratory acidosis. How far is it compensated? Click your answer.
pH 7.14PaCO₂ 73 mmHg (9.7 kPa)HCO₃⁻ 24 mmol/L
1uncompensated
2partially compensated
3fully compensated
12.Arterial blood gas interpretationHard
Practice values: Na⁺ 136, Cl⁻ 111, HCO₃⁻ 16 mmol/L and albumin 29 g/L. Find the albumin-corrected anion gap AGc = AG + 0.25·(40 − albumin).
Interpret this lead II rhythm strip. Which rhythm is it? Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1supraventricular tachycardia (SVT)
2accelerated junctional rhythm
3atrial flutter, 2:1 conduction
4atrial fibrillation
14.ECG rhythm strip interpretationHard
Interpret this lead II strip with the five steps in order: rate, rhythm, P waves, PR interval, QRS duration. At which step do you find the first abnormal finding? Click it.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1rate
2rhythm
3P waves
4PR interval
5QRS duration
15.Prioritization & delegationMedium
Which patient with diabetes should the nurse see first?
AHbA1c result of 8.2%, asking about diet
BGlucose 210 mg/dL (11.7 mmol/L) after a large lunch, feels well
CNeeds foot care teaching before discharge tomorrow
DGlucose 48 mg/dL (2.7 mmol/L), sweating and confused
16.Prioritization & delegationHard
Four patients arrive at the emergency department together. Who should be seen first?
AAn adult with a deformed ankle and a normal pulse in the foot
BA 2-year-old who is drooling, sitting forward and has stridor
CAn adult with a migraine and a blood pressure of 150/90 mmHg
DA teenager with a cut on the arm whose bleeding is controlled
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: D · Hanging the legs down over the side of the bed
Why this is the answer
Ischaemic rest pain is often relieved by lowering the legs, which improves arterial flow by gravity. Elevation worsens ischaemia. Compression is contraindicated in significant arterial disease, and direct heat can burn insensitive, ischaemic skin.
Answer
D · Hanging the legs down over the side of the bed
2.Med-surg: cardiovascular & respiratory
Answer: A · Withhold warfarin, inform the prescriber and recheck the INR soon
Why this is the answer
A very high INR without bleeding is usually managed by withholding warfarin, informing the prescriber and repeating the INR. Low-dose oral vitamin K may also be prescribed depending on the INR and local protocol (UK guidance gives it above an INR of 8; US guidance mainly above 10 or with high bleeding risk). Prothrombin complex concentrate and IV vitamin K are used for major bleeding. Protamine reverses heparin. The reason for the rise (new drugs, illness, diet) should be explored.
Answer
A · Withhold warfarin, inform the prescriber and recheck the INR soon
3.Med-surg: neuro, endocrine & renal
Answer: D · Carbimazole has a higher risk of birth defects early on
Why this is the answer
Carbimazole is linked to congenital abnormalities when used in early pregnancy, so propylthiouracil is often used in the first trimester. Propylthiouracil can cause serious liver injury, so it is not preferred at other times.
Answer
D · Carbimazole has a higher risk of birth defects early on
4.Med-surg: neuro, endocrine & renal
Answer: A · The dose is too high
Why this is the answer
A suppressed TSH with raised free T4 and hyperthyroid symptoms in a patient on levothyroxine suggests over-replacement. The prescriber usually lowers the dose. Long-term over-replacement increases the risk of atrial fibrillation and bone loss.
Answer
A · The dose is too high
5.Med-surg: GI, perioperative & oncology
Answer: D · Alternate staples first, then the rest if the wound holds
Why this is the answer
Removing alternate staples first allows the nurse to check that the wound edges stay together. If the wound is secure, the rest are removed, and adhesive strips can be applied for support.
Answer
D · Alternate staples first, then the rest if the wound holds
6.Med-surg: GI, perioperative & oncology
Answer: D · Consider an alternative; if an NSAID is needed, add a PPI
Why this is the answer
Older age and a previous ulcer greatly increase NSAID-related bleeding. Safer options are considered first; if an NSAID is needed, the lowest effective dose for the shortest time is used with gastroprotection such as a PPI.
Answer
D · Consider an alternative; if an NSAID is needed, add a PPI
7.Clinical nursing
Answer: C · Avoid large meals late in the evening and raise the head of the bed
Why this is the answer
Smaller meals, not eating close to bedtime, raising the head of the bed, weight loss and stopping smoking reduce reflux. Lying flat after eating makes it worse.
Answer
C · Avoid large meals late in the evening and raise the head of the bed
8.Clinical nursing
Answer: C · To rule out septic arthritis, which can rapidly destroy the joint
Why this is the answer
Septic arthritis can destroy cartilage within days. Aspiration allows microscopy and culture, and helps distinguish infection from crystal arthritis such as gout.
Answer
C · To rule out septic arthritis, which can rapidly destroy the joint
9.Lab values & electrolytes
Answer: B · Anti-HBs of 10 mIU/mL or more
Why this is the answer
An anti-HBs level of at least 10 mIU/mL after vaccination indicates protection. HBsAg and IgM anti-HBc indicate infection, not immunity. Health care workers are often tested after vaccination.Checked against:Hepatitis virus panel · MedlinePlus (NIH) (2024)
Answer
B · Anti-HBs of 10 mIU/mL or more
10.Lab values & electrolytes
Answer: D · A sodium of 126 mEq/L
Why this is the answer
Surgical stress raises antidiuretic hormone, and hypotonic fluids add free water, so sodium falls. Hyponatremia causes headache, nausea and confusion. The other values are normal.Checked against:Low blood sodium · MedlinePlus (NIH) (2025); Syndrome of inappropriate antidiuretic hormone secretion · MedlinePlus (NIH) (2025); Hyponatremia · StatPearls (NCBI Bookshelf)
Answer
D · A sodium of 126 mEq/L
11.Arterial blood gas interpretation
Answer: uncompensated
Reading a blood gas (ROME): first the pH: below 7.35 is acidaemia, above 7.45 alkalaemia. Then find the value that explains it. PaCO₂ (normal 35–45 mmHg, 4.7–6.0 kPa) is the respiratory part and moves Opposite to the pH in a respiratory disorder; HCO₃⁻ (normal 22–26 mmol/L) is the metabolic part and moves in the same direction as the pH (Respiratory Opposite, Metabolic Equal). The other value shows the compensation: normal means uncompensated; abnormal in the direction that pulls the pH back while the pH is still abnormal means partially compensated; a normal pH with both values abnormal means fully compensated. Ranges differ slightly between laboratories; these are practice values.
ROME, value by value
pH 7.14: acidaemia (below 7.35)
PaCO₂ 73 mmHg: high (35–45)
HCO₃⁻ 24 mmol/L: normal (22–26)
Compensation
uncompensated
Answer
uncompensated
12.Arterial blood gas interpretation
Answer: AGc = 11.75 mmol/L
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Anion gap
AG = 136 − (111 + 16) = 9
Correction for albumin
9 + 0.25·(40 − 29) = 11.75 mmol/L
Answer
AGc = 11.75 mmol/L
Still within about 8–12 after correction.
13.ECG rhythm strip interpretation
Answer: supraventricular tachycardia (SVT)
Rhythm criteria (lead II): sinus rhythm has an upright P wave before every QRS, a constant PR of 0.12–0.20 s and a narrow QRS: normal sinus rhythm at 60–100/min, sinus bradycardia below 60, sinus tachycardia above 100. Atrial fibrillation: no P waves, a fibrillatory baseline and an irregularly irregular R–R. Atrial flutter: sawtooth flutter waves at about 250–350/min with a fixed conduction ratio such as 2:1 or 4:1. First-degree AV block: sinus rhythm with a constant PR above 0.20 s. Junctional rhythm: narrow QRS at 40–60/min with absent or inverted P waves (PR below 0.12 s, or P after the QRS). A PVC is an early, wide (0.12 s or more), bizarre QRS without a P wave, with the T wave in the opposite direction and usually a full compensatory pause; in bigeminy every second beat is a PVC. Narrow-complex tachycardia and pauses: supraventricular tachycardia (SVT) is a regular tachycardia at about 150–250/min with narrow QRS complexes; the P waves are usually not visible because they are hidden in the QRS complex or the T wave. Sinus tachycardia in an adult at rest is usually below about 150/min and has a visible P wave before every QRS; atrial flutter with 2:1 conduction often runs at about 150/min and shows sawtooth waves. In sinus arrest the sinus node stops firing for a moment: a pause with no P wave and no QRS whose length is not a whole number of P–P cycles (a pause of exactly two or three cycles points to sinus exit block instead).
Five steps
1. Rate: R–R = 6 small boxes, 1500 ÷ 6 ≈ 250 per minute.
2. Rhythm: regular, every R–R is 0.24 s.
3. P waves: none visible; at this rate they are hidden in the QRS complexes or the T waves.
4. PR interval: not measurable.
5. QRS: 0.08 s, narrow (below 0.12 s), so the rhythm starts above the ventricles.
Interpretation
supraventricular tachycardia (SVT)
Answer
supraventricular tachycardia (SVT)
14.ECG rhythm strip interpretation
Answer: QRS duration
Five steps for every strip: 1. rate (300 or 1500 method, or the 6-second method if irregular); 2. rhythm: are the R–R intervals equal; 3. P waves: present, upright in lead II, one before every QRS and all alike; 4. PR interval: 0.12–0.20 s and constant; 5. QRS duration: below 0.12 s. Only after the five steps name the rhythm. Normal sinus rhythm passes all five: 60–100/min, regular, upright P before every QRS, PR 0.12–0.20 s, QRS below 0.12 s.
Five steps
1. Rate: R–R = 20 small boxes, 1500 ÷ 20 ≈ 75 per minute.
2. Rhythm: regular, every R–R is 0.80 s.
3. P waves: upright, one before every QRS, all alike.
4. PR interval: 0.18 s, constant, within 0.12–0.20 s.
5. QRS: 0.14 s, wide (0.12 s or more).
First abnormal step
QRS duration → sinus rhythm with wide QRS
Answer
QRS duration
15.Prioritization & delegation
Answer: D · Glucose 48 mg/dL (2.7 mmol/L), sweating and confused
Why this is the answer
Severe hypoglycemia with confusion can quickly lead to seizures and loss of consciousness. The other patients have problems that matter but are not immediately dangerous.
Answer
D · Glucose 48 mg/dL (2.7 mmol/L), sweating and confused
16.Prioritization & delegation
Answer: B · A 2-year-old who is drooling, sitting forward and has stridor
Why this is the answer
Drooling, a forward-leaning (tripod) position and stridor suggest a severe upper airway obstruction, such as epiglottitis, which can become complete quickly. The child should be kept calm and the throat not examined until airway experts are present.
Answer
B · A 2-year-old who is drooling, sitting forward and has stridor