Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
Before compression therapy is applied for a venous leg ulcer, which assessment is essential?
AA full blood count and CRP
BA chest X-ray and ECG
CA wound swab for culture and sensitivity
DAn ankle–brachial pressure index (ABPI)
2.Med-surg: cardiovascular & respiratoryHard
As the defibrillator charges, a nurse sees a colleague still holding the patient's bed rail. What should the nurse do?
ADeliver the shock now, as the bed rail is not part of the patient
BAsk the colleague to hold the patient's hand instead
CTurn off the defibrillator and start a new cycle of CPR
DCall clearly for everyone to stand clear and check before the shock
3.Med-surg: neuro, endocrine & renalMedium
Why is nimodipine given to patients after a subarachnoid haemorrhage?
ATo reduce brain injury from delayed vasospasm
BTo raise the blood pressure and improve perfusion
CTo stop seizures in the first few days
DTo dissolve the blood clot around the aneurysm
4.Med-surg: neuro, endocrine & renalHard
On the first day after a kidney transplant, urine output suddenly falls from 200 mL/h to 10 mL/h. What should the nurse check first?
AThe patient's temperature and pulse
BThat the catheter is not blocked or kinked
CThe patient's blood glucose level
DWhether the patient has eaten
5.Med-surg: GI, perioperative & oncologyMedium
In the UK National Early Warning Score (NEWS2), what does an aggregate score of 5 or more usually trigger?
ADischarge planning for the next day
BAn urgent review by a clinician skilled in acute illness
CRoutine observations once every 12 hours, with no other change in care
DNo change unless the patient complains
6.Med-surg: GI, perioperative & oncologyHard
Why is an SGLT2 inhibitor such as dapagliflozin usually withheld before surgery?
AIt makes the patient's potassium dangerously high
BIt raises the risk of ketoacidosis, even with near-normal glucose
CIt interacts with all general anaesthetic gases and stops them working
DIt causes the surgical wound to bleed more
7.Clinical nursingMedium
What does HbA1c measure?
AInsulin levels after a meal
BBlood glucose at the moment of testing
CThe amount of ketones in the urine
DAverage blood glucose over roughly the previous two to three months
8.Clinical nursingHard
A patient with full mental capacity decides against a treatment that the team thinks is best. What does the Mental Capacity Act 2005 (England and Wales) say?
AThe family may make the decision instead if they disagree with the patient's choice
BThe patient must be assessed by a psychiatrist before refusing
CA person is not treated as lacking capacity just because they make an unwise decision
DThe team may override any decision that it disagrees with if it is serious
9.Lab values & electrolytesMedium
Which treatment lowers serum potassium by moving it into the cells?
AOral potassium chloride supplements
BIV 0.45% sodium chloride infusion
CIV regular insulin given with glucose
DIV calcium gluconate given over 10 minutes
10.Lab values & electrolytesHard
A patient on clozapine for 2 years has been stable. Which statement shows a need for further teaching?
A"I'll report a sore throat or fever at once"
B"I'll tell other doctors that I take clozapine"
C"I can stop my blood tests since I feel well"
D"I'll keep all my scheduled blood test visits"
11.Arterial blood gas interpretationMedium
A practice gas shows PaCO₂ 21 mmHg (2.8 kPa). Use the rule that in acute respiratory alkalosis HCO₃⁻ falls by 2 mmol/L for every 10 mmHg that PaCO₂ is below 40, starting from HCO₃⁻ 24 mmol/L, to find the expected HCO₃⁻.
A practice gas shows a metabolic acidosis: pH 7.32, PaCO₂ 30 mmHg (4.0 kPa), HCO₃⁻ 15 mmol/L. Compare the measured PaCO₂ with Winter’s formula. Click your interpretation.
pH 7.32PaCO₂ 30 mmHg (4.0 kPa)HCO₃⁻ 15 mmol/L
1appropriate compensation
2added respiratory acidosis
3added respiratory alkalosis
13.ECG rhythm strip interpretationMedium
Interpret this lead II rhythm strip. Which rhythm is it? Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1second-degree AV block type II
2normal sinus rhythm
3sinus rhythm with sinus arrest
4sinus bradycardia
14.ECG rhythm strip interpretationHard
This lead II strip shows an AV block with an irregular ventricular rhythm. Use the 6-second method to find the ventricular rate in beats per minute.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
ventricular rate = bpm
15.Prioritization & delegationMedium
Straight after birth, what is the first priority for a healthy-looking newborn?
AGive the first bath to remove the blood and vernix
BDry and warm the baby while checking that it is breathing
CWeigh and measure the baby on the scale
DGive the vitamin K injection before anything else is done
16.Prioritization & delegationHard
A patient with diabetes is sweaty and confused, and no glucose meter is available. The patient can swallow. What should the nurse do?
AGive a dose of rapid-acting insulin in case the glucose is high
BWithhold all food and fluids until a meter is found
CTreat for hypoglycemia with fast-acting oral carbohydrate
DAsk the patient to lie down and sleep it off
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: D · An ankle–brachial pressure index (ABPI)
Why this is the answer
Compression helps venous return but can cause tissue necrosis if the arterial supply is inadequate. The ABPI compares ankle and arm systolic pressures; a value below about 0.8 (or above about 1.3, suggesting calcified vessels) needs specialist review before compression.
Answer
D · An ankle–brachial pressure index (ABPI)
2.Med-surg: cardiovascular & respiratory
Answer: D · Call clearly for everyone to stand clear and check before the shock
Why this is the answer
Before every shock, the operator states a clear warning, checks that nobody is touching the patient or bed and that oxygen is moved away from the chest. Compressions continue during charging in many protocols, then everyone stands clear for the shock. Touching the bed can conduct current to staff.
Answer
D · Call clearly for everyone to stand clear and check before the shock
3.Med-surg: neuro, endocrine & renal
Answer: A · To reduce brain injury from delayed vasospasm
Why this is the answer
Nimodipine, a calcium channel blocker, reduces the risk of poor outcome from delayed cerebral ischaemia caused by vasospasm. Blood pressure must be monitored because it can cause hypotension.
Answer
A · To reduce brain injury from delayed vasospasm
4.Med-surg: neuro, endocrine & renal
Answer: B · That the catheter is not blocked or kinked
Why this is the answer
A sudden drop in output after transplant may be caused by a blocked catheter, often from clots. The nurse checks the tubing and may flush the catheter per protocol, and then escalates urgently, because vascular thrombosis or rejection are also possible.
Answer
B · That the catheter is not blocked or kinked
5.Med-surg: GI, perioperative & oncology
Answer: B · An urgent review by a clinician skilled in acute illness
Why this is the answer
NEWS2 scores respiratory rate, SpO₂, oxygen use, BP, pulse, consciousness or new confusion, and temperature. A score of 5–6 needs an urgent response, and 7 or more an emergency response.
Answer
B · An urgent review by a clinician skilled in acute illness
6.Med-surg: GI, perioperative & oncology
Answer: B · It raises the risk of ketoacidosis, even with near-normal glucose
Why this is the answer
SGLT2 inhibitors can cause euglycaemic diabetic ketoacidosis around fasting and surgery. They are usually paused before surgery as advised, and ketones are checked if the patient becomes unwell.
Answer
B · It raises the risk of ketoacidosis, even with near-normal glucose
7.Clinical nursing
Answer: D · Average blood glucose over roughly the previous two to three months
Why this is the answer
HbA1c reflects glycation of haemoglobin over the life of red cells, giving an estimate of long-term glucose control.
Answer
D · Average blood glucose over roughly the previous two to three months
8.Clinical nursing
Answer: C · A person is not treated as lacking capacity just because they make an unwise decision
Why this is the answer
One of the Act's principles is that making an unwise decision is not, on its own, evidence of incapacity. The team should check understanding, explore reasons and document the discussion.
Answer
C · A person is not treated as lacking capacity just because they make an unwise decision
9.Lab values & electrolytes
Answer: C · IV regular insulin given with glucose
Why this is the answer
Insulin activates the sodium–potassium pump and moves potassium into the cells; glucose is given with it to prevent hypoglycemia. Calcium gluconate protects the heart but does not lower the potassium level.Checked against:High potassium level · MedlinePlus (NIH) (2025)
Answer
C · IV regular insulin given with glucose
10.Lab values & electrolytes
Answer: C · "I can stop my blood tests since I feel well"
Why this is the answer
Clozapine requires ongoing ANC monitoring according to the schedule, because severe neutropenia can occur without warning. The patient must keep blood test appointments and report signs of infection at once.
Answer
C · "I can stop my blood tests since I feel well"
11.Arterial blood gas interpretation
Answer: HCO₃⁻ = 20.2 mmol/L
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Change in PaCO₂
|21 − 40| = 19 mmHg → 1.9 × 10 mmHg
Expected HCO₃⁻
HCO₃⁻ = 24 − 2·1.9 = 20.2 mmol/L
Answer
HCO₃⁻ = 20.2 mmol/L
12.Arterial blood gas interpretation
Answer: appropriate compensation
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Expected PaCO₂
1.5·15 + 8 = 30.5 → 28.5–32.5 mmHg
Compare
measured: 30 mmHg → appropriate compensation
Answer
appropriate compensation
13.ECG rhythm strip interpretation
Answer: sinus rhythm with sinus arrest
Rhythm criteria (lead II): sinus rhythm has an upright P wave before every QRS, a constant PR of 0.12–0.20 s and a narrow QRS: normal sinus rhythm at 60–100/min, sinus bradycardia below 60, sinus tachycardia above 100. Atrial fibrillation: no P waves, a fibrillatory baseline and an irregularly irregular R–R. Atrial flutter: sawtooth flutter waves at about 250–350/min with a fixed conduction ratio such as 2:1 or 4:1. First-degree AV block: sinus rhythm with a constant PR above 0.20 s. Junctional rhythm: narrow QRS at 40–60/min with absent or inverted P waves (PR below 0.12 s, or P after the QRS). A PVC is an early, wide (0.12 s or more), bizarre QRS without a P wave, with the T wave in the opposite direction and usually a full compensatory pause; in bigeminy every second beat is a PVC. Narrow-complex tachycardia and pauses: supraventricular tachycardia (SVT) is a regular tachycardia at about 150–250/min with narrow QRS complexes; the P waves are usually not visible because they are hidden in the QRS complex or the T wave. Sinus tachycardia in an adult at rest is usually below about 150/min and has a visible P wave before every QRS; atrial flutter with 2:1 conduction often runs at about 150/min and shows sawtooth waves. In sinus arrest the sinus node stops firing for a moment: a pause with no P wave and no QRS whose length is not a whole number of P–P cycles (a pause of exactly two or three cycles points to sinus exit block instead).
Five steps
1. Rate: 5 QRS complexes in 6 s, × 10 = 50 per minute.
2. Rhythm: regular (R–R 0.92 s) except for one pause of 2.12 s, which is not a whole number of P–P cycles.
3. P waves: upright, one before every QRS; no P wave at all during the pause.
4. PR interval: 0.18 s, constant, within 0.12–0.20 s.
5. QRS: 0.10 s, narrow (below 0.12 s).
Interpretation
sinus rhythm with sinus arrest
Answer
sinus rhythm with sinus arrest
14.ECG rhythm strip interpretation
Answer: ventricular rate = 60 bpm
AV blocks: march out the P waves and check which ones are followed by a QRS. First-degree: every P conducted, PR constant and above 0.20 s. Second-degree type I (Mobitz I, Wenckebach): the PR lengthens from beat to beat until one P wave is not conducted, then the cycle starts again (group beating). Second-degree type II (Mobitz II): the PR of the conducted beats stays constant, and P waves are suddenly not conducted; the QRS is often wide. Third-degree (complete) block: P waves and QRS complexes are each regular but independent, the PR varies at random and the atrial rate is faster than the escape rate (junctional 40–60/min with a narrow QRS, ventricular 20–40/min with a wide QRS). A 2:1 block cannot be called type I or type II from one strip.
Atrial rate
P–P = 19 small boxes = 0.76 s → 1500 ÷ 19 = 78.95 ≈ 79 per minute
Ventricular rate
6 QRS complexes in 6 s × 10 = 60 per minute
Answer
ventricular rate = 60 bpm
Answer
ventricular rate = 60 bpm
Second-degree type II: 4 P waves for every 3 QRS complexes, with a constant PR.
15.Prioritization & delegation
Answer: B · Dry and warm the baby while checking that it is breathing
Why this is the answer
Breathing and keeping warm come first. Drying stimulates breathing and reduces heat loss; skin-to-skin contact helps. Weighing and routine injections can wait.
Answer
B · Dry and warm the baby while checking that it is breathing
16.Prioritization & delegation
Answer: C · Treat for hypoglycemia with fast-acting oral carbohydrate
Why this is the answer
When in doubt, treat as hypoglycemia. A little sugar will not harm a patient with high glucose, but untreated hypoglycemia can cause brain injury within minutes, and insulin could be fatal.
Answer
C · Treat for hypoglycemia with fast-acting oral carbohydrate