Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
A patient with a long QT interval develops a polymorphic ventricular tachycardia that twists around the baseline but still has a pulse. Which drug is used first?
AIntravenous potassium chloride as a bolus
BIntravenous magnesium sulfate
CIntravenous adenosine
DOral digoxin
2.Med-surg: cardiovascular & respiratoryHard
Two days after coronary artery bypass surgery, a patient feels palpitations. The pulse is irregularly irregular at 140/min and BP is 112/70 mmHg. Which rhythm is most likely?
ASinus tachycardia
BVentricular fibrillation
CComplete heart block
DAtrial fibrillation
3.Med-surg: neuro, endocrine & renalMedium
Which measure best prevents catheter-associated urinary tract infection?
AChange the catheter for a new one every day
BDisconnect the bag regularly to empty it
CKeep the drainage bag above bladder level
DRemove the catheter as soon as it is no longer needed
4.Med-surg: neuro, endocrine & renalHard
A patient taking digoxin has a potassium of 2.9 mmol/L. Why is this especially dangerous?
ALow potassium makes digoxin leave the body faster
BLow potassium increases the risk of digoxin toxicity
CDigoxin raises the potassium to dangerous levels
DDigoxin stops working when potassium is low
5.Med-surg: GI, perioperative & oncologyMedium
Why is the "whoosh" test no longer used to check nasogastric tube position?
AAir can be heard even when the tube is in the lung
BIt needs an X-ray machine at the bedside
CThe air always makes the tube block
DThe test is far too painful for most patients to tolerate
6.Med-surg: GI, perioperative & oncologyHard
Shortly after a spinal anaesthetic, a patient says their arms feel weak and it is hard to breathe, and the BP is falling. What is most likely?
AA normal spinal effect
BA high spinal block
CAn anxiety attack
DA post-dural puncture headache
7.Clinical nursingMedium
In UK guidance, neutropenic sepsis is commonly defined by a temperature above 38 °C or signs of sepsis with a neutrophil count at or below:
A15 × 109/L
B0.5 × 109/L
C5 × 109/L
D150 × 109/L
8.Clinical nursingHard
An older patient has fallen several times since starting a new medicine. Which drug group is most likely to contribute?
AVitamin D supplements
BBenzodiazepine sleeping tablets
CEmollient creams applied to the legs
DLubricating eye drops
9.Lab values & electrolytesMedium
Which finding during a transfusion suggests transfusion-associated circulatory overload (TACO)?
ABack pain with dark red urine output
BHives and itching without other signs
CCrackles, hypertension and a raised BNP
DA low temperature and slow heart rate
10.Lab values & electrolytesHard
A patient with diabetic ketoacidosis is receiving an IV insulin infusion. Which laboratory value must be monitored especially closely?
AAlbumin, because insulin makes the liver stop producing it
BSodium, because insulin causes the kidneys to excrete very large amounts of it
CHemoglobin, because insulin breaks down red blood cells
DPotassium, because insulin moves it into the cells and it can fall quickly
11.Arterial blood gas interpretationMedium
A practice gas shows PaCO₂ 60 mmHg (8.0 kPa). Use the rule that in acute respiratory acidosis HCO₃⁻ rises by 1 mmol/L for every 10 mmHg that PaCO₂ is above 40, starting from HCO₃⁻ 24 mmol/L, to find the expected HCO₃⁻.
Practice values: Na⁺ 143, Cl⁻ 94 and HCO₃⁻ 16 mmol/L. Calculate the delta ratio (AG − 12)/(24 − HCO₃⁻), using AG = Na⁺ − (Cl⁻ + HCO₃⁻). Give two decimals.
Na⁺ 143 mmol/LCl⁻ 94 mmol/LHCO₃⁻ 16 mmol/L
delta ratio =
13.ECG rhythm strip interpretationMedium
Measure the QT interval and the R–R interval on this regular lead II strip, then calculate the rate-corrected QTc with Fridericia’s formula QTc = QT/∛RR (both in seconds). Give the answer in seconds to three decimals.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
QTc = s
14.ECG rhythm strip interpretationHard
Interpret this lead II strip. Which interpretation can you defend from this single strip? Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1sinus bradycardia
2second-degree AV block type I (Wenckebach)
32:1 AV block (type undetermined)
4second-degree AV block type II
15.Prioritization & delegationMedium
A registered nurse tells a nursing assistant, “Check on the patient in room 12.” Which right of delegation is missing?
ARight circumstance
BRight person for the task
CRight task for the setting
DRight directions and communication
16.Prioritization & delegationHard
A patient admitted with a stroke this morning asks for a glass of water. What should the nurse do first?
ACheck that a swallow screen has been done before giving anything by mouth
BGive the water through a straw so it goes down slowly
CAsk the family to help the patient drink while sitting upright in a chair at the bedside
DGive thickened fluids without checking the swallow
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: B · Intravenous magnesium sulfate
Why this is the answer
Torsades de pointes is treated with IV magnesium, plus correction of low potassium and stopping drugs that prolong the QT interval. If the patient loses their pulse, defibrillation is needed. Potassium must never be given as an IV bolus.
Answer
B · Intravenous magnesium sulfate
2.Med-surg: cardiovascular & respiratory
Answer: D · Atrial fibrillation
Why this is the answer
New atrial fibrillation affects a large proportion of patients in the first days after cardiac surgery, often due to inflammation, electrolyte shifts and stress. Management includes a 12-lead ECG, checking potassium and magnesium, rate or rhythm control and considering anticoagulation.
Answer
D · Atrial fibrillation
3.Med-surg: neuro, endocrine & renal
Answer: D · Remove the catheter as soon as it is no longer needed
Why this is the answer
The risk of CAUTI rises with each day a catheter is in place. Avoiding unnecessary catheters and removing them early are the most effective measures. A closed system and keeping the bag below bladder level also help.
Answer
D · Remove the catheter as soon as it is no longer needed
4.Med-surg: neuro, endocrine & renal
Answer: B · Low potassium increases the risk of digoxin toxicity
Why this is the answer
Digoxin binds to the sodium–potassium pump, and low potassium increases this binding. Hypokalaemia therefore raises the risk of toxicity and arrhythmias, even with a normal digoxin level. The potassium is corrected and the patient monitored.
Answer
B · Low potassium increases the risk of digoxin toxicity
5.Med-surg: GI, perioperative & oncology
Answer: A · Air can be heard even when the tube is in the lung
Why this is the answer
Auscultation of injected air cannot distinguish the stomach from the lungs or oesophagus, and misplaced tubes have caused deaths. pH testing of aspirate or X-ray is used instead.
Answer
A · Air can be heard even when the tube is in the lung
6.Med-surg: GI, perioperative & oncology
Answer: B · A high spinal block
Why this is the answer
If local anaesthetic spreads upwards, it can affect the arms, breathing muscles and cardiac nerves, causing hypotension and bradycardia. It is an emergency; help is called, and breathing and circulation are supported.
Answer
B · A high spinal block
7.Clinical nursing
Answer: B · 0.5 × 109/L
Why this is the answer
Neutropenic sepsis is defined by a neutrophil count of 0.5 × 109/L or lower with fever or other signs of sepsis. It needs empirical antibiotics within one hour.
Answer
B · 0.5 × 109/L
8.Clinical nursing
Answer: B · Benzodiazepine sleeping tablets
Why this is the answer
Sedatives, hypnotics, antipsychotics and drugs that lower blood pressure increase falls risk. A medication review is part of every falls assessment.
Answer
B · Benzodiazepine sleeping tablets
9.Lab values & electrolytes
Answer: C · Crackles, hypertension and a raised BNP
Why this is the answer
TACO is fluid overload, often in older adults or those with heart or kidney disease. It causes dyspnea, crackles, hypertension, distended neck veins and a raised BNP. The transfusion is stopped, the patient is sat up and diuretics may be prescribed.
Answer
C · Crackles, hypertension and a raised BNP
10.Lab values & electrolytes
Answer: D · Potassium, because insulin moves it into the cells and it can fall quickly
Why this is the answer
In DKA the body has lost potassium in the urine, but the serum level may be normal or high because acidosis and lack of insulin shift potassium out of cells. Insulin drives it back in, so the level can fall fast. Potassium is checked often and replaced as prescribed.
Answer
D · Potassium, because insulin moves it into the cells and it can fall quickly
11.Arterial blood gas interpretation
Answer: HCO₃⁻ = 26 mmol/L
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Change in PaCO₂
|60 − 40| = 20 mmHg → 2 × 10 mmHg
Expected HCO₃⁻
HCO₃⁻ = 24 + 1·2 = 26 mmol/L
Answer
HCO₃⁻ = 26 mmol/L
12.Arterial blood gas interpretation
Answer: delta ratio = 2.625
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Anion gap
AG = 143 − (94 + 16) = 33
Delta ratio
(33 − 12)/(24 − 16) = 21/8 = 2.625
Answer
delta ratio = 2.625
Above 2: an added metabolic alkalosis.
13.ECG rhythm strip interpretation
Answer: QTc = 0.455 s
QT and QTc: the QT interval runs from the start of the QRS complex to the end of the T wave. It shortens as the heart rate rises, so it is corrected for rate with the R–R interval in seconds: Bazett QTc = QT/√RR and Fridericia QTc = QT/∛RR. Bazett is the formula most textbooks use; it over-corrects at fast rates, where Fridericia is preferred. Limits differ between references: a QTc above about 0.45 s in men or 0.46 s in women is usually called prolonged, and above 0.50 s markedly prolonged.
Measure
QT = 10 × 0.04 = 0.40 s
RR = 17 × 0.04 = 0.68 s
Fridericia’s formula
QTc = 0.40/∛0.68 = 0.40/0.8794 = 0.455 s
Answer
QTc = 0.455 s
Between the usual limits for men (about 0.45 s) and women (about 0.46 s): borderline, depending on the reference used. (455 ms)
14.ECG rhythm strip interpretation
Answer: 2:1 AV block (type undetermined)
2:1 AV block: with two P waves for every QRS, no two conducted P waves follow each other, so you cannot see whether the PR would lengthen (type I) or stay constant (type II) before a non-conducted P wave. From one strip it is called a 2:1 AV block; a longer strip or a change in the conduction ratio decides the type. A narrow QRS makes type I more likely and a wide QRS type II, but neither proves it.
Five steps
1. Rate: R–R = 36 small boxes, 1500 ÷ 36 ≈ 42 per minute.
2. Rhythm: regular, every R–R is 1.44 s.
3. P waves: upright and regular (P–P 0.72 s, 83 per minute), two for every QRS.
4. PR interval: constant at 0.18 s in the conducted beats.
5. QRS: 0.14 s, wide (0.12 s or more).
Why the type stays open
Every second P wave is not conducted, so no two conducted beats follow each other and a lengthening PR could never show.
2:1 AV block (type undetermined)
Answer
2:1 AV block (type undetermined)
A narrow QRS makes type I more likely and a wide QRS type II, but only a longer strip or a change in the conduction ratio decides.
15.Prioritization & delegation
Answer: D · Right directions and communication
Why this is the answer
“Check on” does not say what to measure, when, or which findings to report. A clear instruction would be, for example, “Measure his blood pressure and pulse at 10:00 and tell me at once if the systolic is below 100.”
Answer
D · Right directions and communication
16.Prioritization & delegation
Answer: A · Check that a swallow screen has been done before giving anything by mouth
Why this is the answer
After a stroke, the patient stays NPO (nothing by mouth) until a swallow screen shows it is safe. Giving fluids first risks aspiration, even with a straw or thickener.
Answer
A · Check that a swallow screen has been done before giving anything by mouth