Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
After an acute coronary syndrome, a patient with a normal cholesterol level is prescribed a high-intensity statin. Why?
AStatins work as painkillers for chest pain
BStatins are given after an ACS mainly to lower the blood pressure
CStatins reduce further events whatever the starting cholesterol
DStatins are needed only if the cholesterol level is very high
2.Med-surg: cardiovascular & respiratoryHard
One hour after cardiac surgery, a mediastinal chest drain has drained 350 mL of bright red blood and the heart rate is rising. What should the nurse do?
ARecord the volume and continue hourly checks
BStrip the tubing hard every five minutes
CReport it to the surgical team at once
DClamp the drain to stop further blood loss
3.Med-surg: neuro, endocrine & renalMedium
Which complication of haemodialysis causes headache, nausea, restlessness and sometimes seizures, especially in the first sessions?
AVenous air embolism through the lines
BBacterial peritonitis
CDialysate hypoglycaemia
DDialysis disequilibrium syndrome
4.Med-surg: neuro, endocrine & renalHard
A nurse teaches a patient about peritoneal dialysis. Which statement shows a need for further teaching?
A"If the fluid is cloudy, I'll see if it clears next time."
B"I will weigh myself daily and record my fluid balance."
C"I will wash my hands carefully before each exchange."
D"I will check my exit site every day."
5.Med-surg: GI, perioperative & oncologyMedium
Which bedside assessments are used to follow ascites?
ADaily weight and abdominal girth
BCapillary glucose before each meal
CPupil size and reaction twice daily
DPeak flow and oxygen saturation
6.Med-surg: GI, perioperative & oncologyHard
Which history should most alert the nurse to a possible latex allergy before surgery?
AA rash after taking amoxicillin as a child, with a family history of asthma
BItching with bananas, avocado and kiwi, and many operations
CHay fever every spring since childhood
DFeeling sick after eating shellfish once
7.Clinical nursingMedium
After a laparoscopic cholecystectomy, a patient has pain in the shoulder tip. What is the most likely cause?
AGas used during the operation irritating the diaphragm
BAn allergic reaction to the dressing
CA heart attack caused by the stress of surgery
DA broken collarbone from being moved onto the table
8.Clinical nursingHard
A patient who used sildenafil the day before develops chest pain. Why is glyceryl trinitrate (GTN, nitroglycerin) normally avoided?
AThe combination causes severe hyperkalaemia
BThe combination can cause a severe, dangerous fall in blood pressure
CGTN makes sildenafil toxic to the liver
DSildenafil stops GTN from being absorbed under the tongue at all
9.Lab values & electrolytesMedium
A patient had a total gastrectomy. Which long-term therapy is needed to prevent anemia?
AWeekly doses of oral vitamin K tablets
BLifelong oral folic acid tablets only
CMonthly transfusions of red blood cells
DLifelong vitamin B12 replacement
10.Lab values & electrolytesHard
Four drug levels are reported. Which patient should the nurse assess first?
AValproate 75 mcg/mL with no symptoms
BLithium 1.8 mEq/L with a new coarse tremor
CDigoxin 1.0 ng/mL with a pulse of 72/min
DPhenytoin 15 mcg/mL with no symptoms
11.Arterial blood gas interpretationMedium
A practice arterial blood gas shows pH 7.33, PaCO₂ 78 mmHg (10.4 kPa) and HCO₃⁻ 40 mmol/L. The primary disorder is respiratory acidosis. How far is it compensated? Click your answer.
pH 7.33PaCO₂ 78 mmHg (10.4 kPa)HCO₃⁻ 40 mmol/L
1uncompensated
2partially compensated
3fully compensated
12.Arterial blood gas interpretationHard
A practice gas shows a metabolic acidosis: pH 7.10, PaCO₂ 30 mmHg (4.0 kPa), HCO₃⁻ 9 mmol/L. Compare the measured PaCO₂ with Winter’s formula. Click your interpretation.
pH 7.10PaCO₂ 30 mmHg (4.0 kPa)HCO₃⁻ 9 mmol/L
1appropriate compensation
2added respiratory acidosis
3added respiratory alkalosis
13.ECG rhythm strip interpretationMedium
Measure the QT interval and the R–R interval on this regular lead II strip, then calculate the rate-corrected QTc with Fridericia’s formula QTc = QT/∛RR (both in seconds). Give the answer in seconds to three decimals.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
QTc = s
14.ECG rhythm strip interpretationHard
This lead II strip shows an AV block, so the atria and the ventricles beat at different rates. The QRS complexes are regular: find the ventricular rate in beats per minute (1500 method, whole number).
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
ventricular rate = bpm
15.Prioritization & delegationMedium
During an IV vancomycin infusion, a patient develops flushing and itching of the face and neck. What should the nurse do first?
AApply a warm compress to the face and neck
BStop or slow the infusion and inform the provider
CSpeed up the infusion to finish it quickly
DIgnore it, because flushing is always harmless and passes
16.Prioritization & delegationHard
A child who had a tonsillectomy this morning is swallowing again and again while asleep. What should the nurse suspect?
AHunger after fasting for surgery
BBleeding from the operation site
CNormal swallowing during sleep
DA sore throat from the breathing tube
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: C · Statins reduce further events whatever the starting cholesterol
Why this is the answer
After ACS, high-intensity statin therapy reduces recurrent MI, stroke and death regardless of baseline cholesterol, partly by stabilising plaques. It is part of standard secondary prevention with antiplatelets, beta-blockers, ACE inhibitors and lifestyle change.
Answer
C · Statins reduce further events whatever the starting cholesterol
2.Med-surg: cardiovascular & respiratory
Answer: C · Report it to the surgical team at once
Why this is the answer
Drainage of more than about 100–200 mL/h (or a sudden large volume of fresh blood), especially with tachycardia or hypotension, may indicate surgical bleeding and needs urgent review. Clamping could cause cardiac tamponade. A sudden stop in drainage with falling blood pressure can also signal tamponade.
Answer
C · Report it to the surgical team at once
3.Med-surg: neuro, endocrine & renal
Answer: D · Dialysis disequilibrium syndrome
Why this is the answer
Rapid removal of urea from the blood creates an osmotic gradient, so water moves into brain cells, causing cerebral oedema. It is prevented by shorter, gentler first sessions.
Answer
D · Dialysis disequilibrium syndrome
4.Med-surg: neuro, endocrine & renal
Answer: A · "If the fluid is cloudy, I'll see if it clears next time."
Why this is the answer
Cloudy effluent may be the first sign of peritonitis and must be reported to the PD unit straight away, keeping the bag for testing. Waiting can allow a serious infection to develop.
Answer
A · "If the fluid is cloudy, I'll see if it clears next time."
5.Med-surg: GI, perioperative & oncology
Answer: A · Daily weight and abdominal girth
Why this is the answer
Daily weights and abdominal girth measured at the same marked level show whether ascites is increasing or decreasing. Fluid balance, renal function and electrolytes are also monitored, especially on diuretics.
Answer
A · Daily weight and abdominal girth
6.Med-surg: GI, perioperative & oncology
Answer: B · Itching with bananas, avocado and kiwi, and many operations
Why this is the answer
Latex–fruit syndrome links latex allergy with foods such as banana, avocado, kiwi and chestnut. Repeated exposure, for example through many operations or catheters, also increases risk.
Answer
B · Itching with bananas, avocado and kiwi, and many operations
7.Clinical nursing
Answer: A · Gas used during the operation irritating the diaphragm
Why this is the answer
Carbon dioxide used to inflate the abdomen can irritate the diaphragm, causing referred shoulder-tip pain. It usually settles within a few days with mobilisation and analgesia.
Answer
A · Gas used during the operation irritating the diaphragm
8.Clinical nursing
Answer: B · The combination can cause a severe, dangerous fall in blood pressure
Why this is the answer
PDE5 inhibitors such as sildenafil enhance the vasodilating effect of nitrates, which can cause profound hypotension. Patients should always be asked about these drugs before nitrates are given.
Answer
B · The combination can cause a severe, dangerous fall in blood pressure
9.Lab values & electrolytes
Answer: D · Lifelong vitamin B12 replacement
Why this is the answer
Intrinsic factor from the stomach is needed to absorb vitamin B12 in the ileum. After a total gastrectomy, B12 must be replaced for life, usually by injection, to prevent macrocytic anemia and nerve damage.Checked against:Vitamin B12 or folate deficiency anaemia - Causes · NHS (2023); Vitamin B12 deficiency anemia · MedlinePlus (NIH) (2026)
Answer
D · Lifelong vitamin B12 replacement
10.Lab values & electrolytes
Answer: B · Lithium 1.8 mEq/L with a new coarse tremor
Why this is the answer
A lithium level of 1.8 mEq/L with a coarse tremor suggests toxicity, which can progress to confusion and seizures. The digoxin, phenytoin and valproate levels are within commonly cited ranges and the patients are stable.
Answer
B · Lithium 1.8 mEq/L with a new coarse tremor
11.Arterial blood gas interpretation
Answer: partially compensated
Reading a blood gas (ROME): first the pH: below 7.35 is acidaemia, above 7.45 alkalaemia. Then find the value that explains it. PaCO₂ (normal 35–45 mmHg, 4.7–6.0 kPa) is the respiratory part and moves Opposite to the pH in a respiratory disorder; HCO₃⁻ (normal 22–26 mmol/L) is the metabolic part and moves in the same direction as the pH (Respiratory Opposite, Metabolic Equal). The other value shows the compensation: normal means uncompensated; abnormal in the direction that pulls the pH back while the pH is still abnormal means partially compensated; a normal pH with both values abnormal means fully compensated. Ranges differ slightly between laboratories; these are practice values.
ROME, value by value
pH 7.33: acidaemia (below 7.35)
PaCO₂ 78 mmHg: high (35–45)
HCO₃⁻ 40 mmol/L: high (22–26)
Compensation
partially compensated
Answer
partially compensated
12.Arterial blood gas interpretation
Answer: added respiratory acidosis
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Expected PaCO₂
1.5·9 + 8 = 21.5 → 19.5–23.5 mmHg
Compare
measured: 30 mmHg → added respiratory acidosis
Answer
added respiratory acidosis
13.ECG rhythm strip interpretation
Answer: QTc = 0.462 s
QT and QTc: the QT interval runs from the start of the QRS complex to the end of the T wave. It shortens as the heart rate rises, so it is corrected for rate with the R–R interval in seconds: Bazett QTc = QT/√RR and Fridericia QTc = QT/∛RR. Bazett is the formula most textbooks use; it over-corrects at fast rates, where Fridericia is preferred. Limits differ between references: a QTc above about 0.45 s in men or 0.46 s in women is usually called prolonged, and above 0.50 s markedly prolonged.
Measure
QT = 12 × 0.04 = 0.48 s
RR = 28 × 0.04 = 1.12 s
Fridericia’s formula
QTc = 0.48/∛1.12 = 0.48/1.038 = 0.462 s
Answer
QTc = 0.462 s
Above the usual limits for both men (about 0.45 s) and women (about 0.46 s): prolonged. (462 ms)
14.ECG rhythm strip interpretation
Answer: ventricular rate = 36 bpm
AV blocks: march out the P waves and check which ones are followed by a QRS. First-degree: every P conducted, PR constant and above 0.20 s. Second-degree type I (Mobitz I, Wenckebach): the PR lengthens from beat to beat until one P wave is not conducted, then the cycle starts again (group beating). Second-degree type II (Mobitz II): the PR of the conducted beats stays constant, and P waves are suddenly not conducted; the QRS is often wide. Third-degree (complete) block: P waves and QRS complexes are each regular but independent, the PR varies at random and the atrial rate is faster than the escape rate (junctional 40–60/min with a narrow QRS, ventricular 20–40/min with a wide QRS). A 2:1 block cannot be called type I or type II from one strip.
Atrial rate
P–P = 18 small boxes = 0.72 s → 1500 ÷ 18 = 83.33 ≈ 83 per minute
Ventricular rate
R–R = 42 small boxes = 1.68 s → 1500 ÷ 42 = 35.71 ≈ 36 per minute
Answer
ventricular rate = 36 bpm
Answer
ventricular rate = 36 bpm
Third-degree block with a wide-complex ventricular escape (usually 20–40 per minute).
15.Prioritization & delegation
Answer: B · Stop or slow the infusion and inform the provider
Why this is the answer
Flushing of the upper body during vancomycin is usually an infusion reaction related to the rate. The nurse stops or slows the infusion, assesses for anaphylaxis and informs the provider.
Answer
B · Stop or slow the infusion and inform the provider
16.Prioritization & delegation
Answer: B · Bleeding from the operation site
Why this is the answer
Frequent swallowing after tonsillectomy is a classic sign of bleeding. The nurse checks the throat with a light, looks at vital signs and reports at once.