Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
A patient with heart failure takes furosemide once a day. When is the best time to take it?
AJust before the evening meal, with a large drink
BAt bedtime, so the effect lasts through the night
CIn the morning, to avoid needing the toilet at night
DWhenever the ankles look swollen, on those days only
2.Med-surg: cardiovascular & respiratoryHard
A patient taking ramipril and indapamide for hypertension starts regular ibuprofen for back pain. A week later, creatinine has risen sharply. What is the most likely cause?
AAn allergic reaction to the diuretic causing inflammation of the kidney
BBack pain causing kidney damage
CIbuprofen raising the blood pressure to levels that damage the kidneys
DAn ACE inhibitor, diuretic and NSAID together reducing kidney perfusion
3.Med-surg: neuro, endocrine & renalMedium
For which patient would the nurse question an order for pioglitazone?
AA patient with heart failure
BA patient with an allergy to latex
CA patient with asthma
DA patient with hypothyroidism
4.Med-surg: neuro, endocrine & renalHard
A patient has frothy urine and marked leg swelling. Serum albumin is 18 g/L (1.8 g/dL), and BP is normal. The urine shows heavy protein but little blood. What is most likely?
ANephrotic syndrome
BA urethral stricture
CAcute pyelonephritis
DNephritic syndrome
5.Med-surg: GI, perioperative & oncologyMedium
Why may modified-release or enteric-coated tablets not work well for a patient with an ileostomy?
AThe stoma absorbs the drug far too quickly into the blood
BFast transit means it may pass before releasing the drug
CThe ileostomy enzymes destroy every type of oral medicine
DPatients with an ileostomy cannot take any oral medicines
6.Med-surg: GI, perioperative & oncologyHard
A patient asks whether to take their usual bisoprolol on the morning of surgery. What is the usual guidance?
ATake a double dose to protect the heart
BStop it one week before any operation
CUsually continue it with a sip of water, unless told otherwise
DTake it only after the operation is finished
7.Clinical nursingMedium
A patient without diabetes is started on high-dose prednisolone. Why might capillary blood glucose be monitored?
ASteroids destroy the pancreas
BSteroids make glucose meters inaccurate
CSteroids always cause hypoglycaemia
DSteroids can raise the blood glucose
8.Clinical nursingHard
A nurse realises she has given a patient a medicine prescribed for another patient. What should she do first?
AGive the patient's own medicine as well to balance it
BWait to see whether any side effects develop
CCheck the patient's condition and inform the doctor
DAsk a colleague not to mention it
9.Lab values & electrolytesMedium
A patient with pneumonia had a CRP of 180 mg/L on admission and 40 mg/L after 4 days of antibiotics. What does this most likely show?
AThe patient has developed a new infection
BThe antibiotic is causing liver damage
CThe infection has spread to another organ
DThe inflammation is settling with treatment
10.Lab values & electrolytesHard
A patient on IV gentamicin has a trough level above the target, and the creatinine has risen since yesterday. The next dose is due. What is the best action?
AGive half of the dose and document the reason for it
BGive the dose now and recheck the levels next week
CGive the dose with extra oral fluids to protect the kidneys
DHold the dose and report the results to the prescriber
11.Arterial blood gas interpretationMedium
A practice arterial blood gas shows pH 7.42, PaCO₂ 54 mmHg (7.2 kPa) and HCO₃⁻ 34 mmol/L. The primary disorder is metabolic alkalosis. How far is it compensated? Click your answer.
pH 7.42PaCO₂ 54 mmHg (7.2 kPa)HCO₃⁻ 34 mmol/L
1uncompensated
2partially compensated
3fully compensated
12.Arterial blood gas interpretationHard
A practice gas shows a respiratory acidosis: pH 7.24, PaCO₂ 77 mmHg (10.3 kPa), HCO₃⁻ 32 mmol/L. Use the rules ‘HCO₃⁻ rises 1 mmol/L per 10 mmHg (acute) or 3.5 mmol/L per 10 mmHg (chronic)’ to classify it. Click your answer.
pH 7.24PaCO₂ 77 mmHg (10.3 kPa)HCO₃⁻ 32 mmol/L
1acute
2chronic
3acute on chronic
13.ECG rhythm strip interpretationMedium
This lead II strip shows sinus rhythm with one pause. Measure the pause, the R–R interval across it, in seconds.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
pause = s
14.ECG rhythm strip interpretationHard
This lead II strip shows a conduction problem between the atria and the ventricles. Which rhythm is it? Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1first-degree AV block
2atrial fibrillation
3second-degree AV block type I (Wenckebach)
4third-degree (complete) AV block
15.Prioritization & delegationMedium
A patient has a new plaster cast that is still drying. How should the nurse handle it?
ABy covering it tightly with a plastic sheet
BWith the fingertips, pressing firmly to test it
CWith the palms of the hands, not the fingertips
DBy resting it directly on a hard surface
16.Prioritization & delegationHard
A nurse is supervising a new nursing assistant. When should the nurse check the assistant’s work most closely?
AOnly at the end of the shift, when the documentation is reviewed
BOnly when the assistant asks for help with a task they find difficult
CWhen the assistant is new to the task or the patient is less stable
DNever, because the assistant holds a certificate for the role
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: C · In the morning, to avoid needing the toilet at night
Why this is the answer
Loop diuretics produce a brisk diuresis that lasts several hours. Taking them in the morning (and a second dose by early afternoon if prescribed) avoids nocturia, broken sleep and night-time falls.
Answer
C · In the morning, to avoid needing the toilet at night
2.Med-surg: cardiovascular & respiratory
Answer: D · An ACE inhibitor, diuretic and NSAID together reducing kidney perfusion
Why this is the answer
NSAIDs constrict the afferent arteriole, ACE inhibitors dilate the efferent arteriole and diuretics reduce volume. Together (sometimes called the "triple whammy") they can cause acute kidney injury. The NSAID is stopped, and the prescriber reviews the other drugs.
Answer
D · An ACE inhibitor, diuretic and NSAID together reducing kidney perfusion
3.Med-surg: neuro, endocrine & renal
Answer: A · A patient with heart failure
Why this is the answer
Pioglitazone can cause fluid retention and oedema, which can worsen heart failure. It is contraindicated in patients with heart failure. Weight gain and an increased fracture risk are other effects.
Answer
A · A patient with heart failure
4.Med-surg: neuro, endocrine & renal
Answer: A · Nephrotic syndrome
Why this is the answer
Heavy proteinuria, very low albumin and oedema point to nephrotic syndrome. Nephritic syndrome is mainly haematuria with hypertension and reduced urine output. The cause is investigated, often with a biopsy.
Answer
A · Nephrotic syndrome
5.Med-surg: GI, perioperative & oncology
Answer: B · Fast transit means it may pass before releasing the drug
Why this is the answer
Without the colon, gut transit is faster, so slow-release or coated preparations may be poorly absorbed. Tablet remnants may appear in the pouch. A pharmacist can suggest alternative formulations.
Answer
B · Fast transit means it may pass before releasing the drug
6.Med-surg: GI, perioperative & oncology
Answer: C · Usually continue it with a sip of water, unless told otherwise
Why this is the answer
Beta-blockers are usually continued around surgery because sudden withdrawal can cause rebound tachycardia and ischaemia. The patient follows the specific instructions from the preoperative assessment.
Answer
C · Usually continue it with a sip of water, unless told otherwise
7.Clinical nursing
Answer: D · Steroids can raise the blood glucose
Why this is the answer
Glucocorticoids increase glucose production and insulin resistance, causing steroid-induced hyperglycaemia. Glucose monitoring identifies patients who need treatment.
Answer
D · Steroids can raise the blood glucose
8.Clinical nursing
Answer: C · Check the patient's condition and inform the doctor
Why this is the answer
The first priority is the patient: assess them and inform the prescriber so that any treatment can be given. The error must then be documented, reported and discussed openly with the patient (open disclosure; in the UK, the statutory duty of candour).
Answer
C · Check the patient's condition and inform the doctor
9.Lab values & electrolytes
Answer: D · The inflammation is settling with treatment
Why this is the answer
CRP has a short half-life of about 19 hours, so it falls within days when inflammation is controlled. A falling CRP, together with clinical improvement, supports a response to treatment; a CRP that stays high or rises again needs review.Checked against:C-reactive protein · MedlinePlus (NIH) (2025)
Answer
D · The inflammation is settling with treatment
10.Lab values & electrolytes
Answer: D · Hold the dose and report the results to the prescriber
Why this is the answer
A high aminoglycoside trough with rising creatinine means the drug is accumulating, which increases the risk of kidney damage and hearing loss. The nurse holds the dose, reports to the prescriber and asks about hearing changes and tinnitus. Only the prescriber or pharmacist changes the regimen.Checked against:Gentamicin sulfate injection - Boxed Warning (US prescribing information) · Pfizer Medical Information (FDA label)
Answer
D · Hold the dose and report the results to the prescriber
11.Arterial blood gas interpretation
Answer: fully compensated
Reading a blood gas (ROME): first the pH: below 7.35 is acidaemia, above 7.45 alkalaemia. Then find the value that explains it. PaCO₂ (normal 35–45 mmHg, 4.7–6.0 kPa) is the respiratory part and moves Opposite to the pH in a respiratory disorder; HCO₃⁻ (normal 22–26 mmol/L) is the metabolic part and moves in the same direction as the pH (Respiratory Opposite, Metabolic Equal). The other value shows the compensation: normal means uncompensated; abnormal in the direction that pulls the pH back while the pH is still abnormal means partially compensated; a normal pH with both values abnormal means fully compensated. Ranges differ slightly between laboratories; these are practice values.
ROME, value by value
pH 7.42: within 7.35–7.45
PaCO₂ 54 mmHg: high (35–45)
HCO₃⁻ 34 mmol/L: high (22–26)
Compensation
Clinically, also check the expected compensation: for a metabolic alkalosis PaCO₂ ≈ 0.7·HCO₃⁻ + 21 = 42.8–46.8 mmHg, so the measured 54 mmHg points to an additional respiratory acidosis (a mixed disorder). The answer above is the ROME exam classification.
fully compensated
Answer
fully compensated
12.Arterial blood gas interpretation
Answer: acute on chronic
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Expected HCO₃⁻
acute: 24 + 1·3.7 = 27.7 mmol/L
chronic: 24 + 3.5·3.7 = 36.95 mmol/L
Compare
measured: 32 mmol/L → acute on chronic
Answer
acute on chronic
13.ECG rhythm strip interpretation
Answer: pause = 1.76 s
Narrow-complex tachycardia and pauses: supraventricular tachycardia (SVT) is a regular tachycardia at about 150–250/min with narrow QRS complexes; the P waves are usually not visible because they are hidden in the QRS complex or the T wave. Sinus tachycardia in an adult at rest is usually below about 150/min and has a visible P wave before every QRS; atrial flutter with 2:1 conduction often runs at about 150/min and shows sawtooth waves. In sinus arrest the sinus node stops firing for a moment: a pause with no P wave and no QRS whose length is not a whole number of P–P cycles (a pause of exactly two or three cycles points to sinus exit block instead).
Measure
44 small boxes from R to R across the pause
Convert
pause = 44 × 0.04 s = 1.76 s
Compare with P–P
1.76 ÷ 0.72 ≈ 2.4 P–P cycles, not a whole number
Answer
pause = 1.76 s
No P wave appears in the pause, and the pause is not a whole number of P–P cycles: sinus arrest. A pause of exactly two or three cycles would point to sinus exit block.
14.ECG rhythm strip interpretation
Answer: second-degree AV block type I (Wenckebach)
AV blocks: march out the P waves and check which ones are followed by a QRS. First-degree: every P conducted, PR constant and above 0.20 s. Second-degree type I (Mobitz I, Wenckebach): the PR lengthens from beat to beat until one P wave is not conducted, then the cycle starts again (group beating). Second-degree type II (Mobitz II): the PR of the conducted beats stays constant, and P waves are suddenly not conducted; the QRS is often wide. Third-degree (complete) block: P waves and QRS complexes are each regular but independent, the PR varies at random and the atrial rate is faster than the escape rate (junctional 40–60/min with a narrow QRS, ventricular 20–40/min with a wide QRS). A 2:1 block cannot be called type I or type II from one strip.
Five steps
1. Rate: 4 QRS complexes in 6 s, × 10 = 40 per minute.
2. Rhythm: regularly irregular, the QRS complexes come in groups separated by a pause (group beating).
3. P waves: upright and regular (P–P 0.96 s, 63 per minute); one P in every 3 is not followed by a QRS.
4. PR interval: lengthens 0.16 → 0.30 s, then a P wave is not conducted.
5. QRS: 0.08 s, narrow (below 0.12 s).
Interpretation
second-degree AV block type I (Wenckebach)
Answer
second-degree AV block type I (Wenckebach)
15.Prioritization & delegation
Answer: C · With the palms of the hands, not the fingertips
Why this is the answer
A wet plaster cast can be dented by fingertips, causing pressure points under the cast. It is handled with the palms, supported on pillows and left uncovered to dry.
Answer
C · With the palms of the hands, not the fingertips
16.Prioritization & delegation
Answer: C · When the assistant is new to the task or the patient is less stable
Why this is the answer
Supervision is greater when the delegate has less experience, the patient’s condition is less predictable or the task carries more risk. Passive or end-of-shift checking can miss problems while they can still be fixed.
Answer
C · When the assistant is new to the task or the patient is less stable