Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
A patient on nasal cannula oxygen breathes mainly through the mouth. What is the most accurate statement?
AIt can still work, because oxygen collects in the nasopharynx
BThe cannula should be placed in the mouth
CThe flow must be increased to 15 L/min to make it work at all
DIt has no effect at all in mouth breathers and must be stopped
2.Med-surg: cardiovascular & respiratoryHard
A ventilated patient is coughing, and the high-pressure alarm sounds. Coarse sounds are heard over the trachea. What should the nurse do first?
AIncrease the tidal volume on the ventilator to overcome it
BAssess the patient and suction if secretions are present
CDeflate the endotracheal tube cuff fully
DTurn the alarm off and reassess the patient in an hour
3.Med-surg: neuro, endocrine & renalMedium
A man starts finasteride for an enlarged prostate. Which statement is correct?
AIt is used only for a few days at a time
BIt takes months to work; pregnant women must not handle broken tablets
CIt lowers the blood pressure, so dizziness is very common
DIt works within hours by relaxing the bladder muscle
4.Med-surg: neuro, endocrine & renalHard
A patient with myasthenia gravis is admitted with pneumonia. Which newly prescribed antibiotic should the nurse question?
AAmoxicillin
BGentamicin
CBenzylpenicillin
DCeftriaxone
5.Med-surg: GI, perioperative & oncologyMedium
How large should the opening of a stoma appliance be cut?
AAbout 2 cm larger than the stoma all round
BAbout 2–3 mm larger than the stoma all round
CSlightly smaller than the stoma for a tight seal
DAny size, as long as the stoma is covered
6.Med-surg: GI, perioperative & oncologyHard
A patient on an opioid PCA receives oxygen by mask. SpO₂ is 97% and the respiratory rate 11/min, but they are now hard to rouse. What should the nurse conclude?
AThe patient is safe, because the oxygen saturation is normal
BThe patient is simply sleeping well, as the pain is controlled
CThe PCA dose should be increased to keep the patient comfortable
DOpioid toxicity is likely; the oxygen may be masking hypoventilation
7.Clinical nursingMedium
A very anxious patient breathes rapidly for a long period. Which change is expected?
ARespiratory acidosis from a high PaCO2
BMetabolic acidosis from a low bicarbonate
CMetabolic alkalosis from vomiting
DRespiratory alkalosis from a low PaCO2
8.Clinical nursingHard
A patient starting a DOAC is taught about missed doses. Which statement shows a need for further teaching?
A"If I forget a dose, I'll take two the next day to catch up."
B"I will tell other doctors and my dentist I take an anticoagulant."
C"I will report any blood in my urine."
D"I will take it at the same time each day."
9.Lab values & electrolytesMedium
In chronic kidney disease, a high serum phosphate is usually accompanied by which change in calcium?
ANo change in calcium
BA high serum calcium
CA low serum calcium
DA high serum potassium only, with no calcium change
10.Lab values & electrolytesHard
A patient's creatinine was 0.9 mg/dL (80 µmol/L) on admission and is 1.3 mg/dL (115 µmol/L) 36 hours later. Using the common KDIGO criteria, what does this show?
AChronic kidney disease, because creatinine has risen above baseline
BNo kidney injury, because the creatinine is still within the normal range
CAcute kidney injury, because it rose by at least 0.3 mg/dL within 48 hours
DA laboratory error, because creatinine cannot change within 2 days
11.Arterial blood gas interpretationMedium
Practice values: Na⁺ 145 mmol/L, glucose 15.6 mmol/L and urea 24.5 mmol/L. Calculate the serum osmolality Osm = 2·Na⁺ + glucose + urea to the nearest whole number.
Na⁺ 145 mmol/Lglucose 15.6 mmol/Lurea 24.5 mmol/L
Osm = mOsm/kg
12.Arterial blood gas interpretationHard
A practice gas shows a metabolic acidosis: pH 7.11, PaCO₂ 26 mmHg (3.5 kPa), HCO₃⁻ 8 mmol/L. Compare the measured PaCO₂ with Winter’s formula. Click your interpretation.
pH 7.11PaCO₂ 26 mmHg (3.5 kPa)HCO₃⁻ 8 mmol/L
1appropriate compensation
2added respiratory acidosis
3added respiratory alkalosis
13.ECG rhythm strip interpretationMedium
Interpret this lead II rhythm strip. Which rhythm is it? Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1ventricular bigeminy
2atrial fibrillation
3sinus rhythm with PVCs
4normal sinus rhythm
14.ECG rhythm strip interpretationHard
This patient has a pacemaker. Interpret the lead II strip. Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1third-degree (complete) AV block
2idioventricular rhythm
3sinus rhythm with wide QRS
4dual-chamber (AV) paced rhythm
15.Prioritization & delegationMedium
On day 3 after hip surgery, a patient suddenly becomes short of breath with sharp chest pain and an SpO₂ of 88%. What should the nurse do first?
AEncourage the patient to walk to improve the circulation
BGive the next dose of oral analgesia and reassess the patient in an hour
CMassage the patient’s calves to ease any muscle cramp
DRaise the head of the bed, give oxygen and call for urgent help
16.Prioritization & delegationHard
An RN has five patients and a nursing assistant. One patient has just become short of breath. Which task should the RN delegate so that the RN can go to that patient?
AAssessing the breathless patient’s lung sounds
BExplaining the new diagnosis to the breathless patient’s family
CMorning vital signs on the four stable patients
DGiving the breathless patient’s IV furosemide
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: A · It can still work, because oxygen collects in the nasopharynx
Why this is the answer
Studies show that mouth breathing still draws in oxygen from the nasopharynx, so nasal cannulae can work. The effect is judged by the SpO₂, and the device is changed if targets are not reached. Cannulae are never placed in the mouth.
Answer
A · It can still work, because oxygen collects in the nasopharynx
2.Med-surg: cardiovascular & respiratory
Answer: B · Assess the patient and suction if secretions are present
Why this is the answer
High-pressure alarms are caused by secretions, coughing, biting the tube, kinked tubing or bronchospasm. With secretions heard, suctioning is the logical first step after a quick assessment. Low-pressure alarms suggest a leak or disconnection. Alarms must never be silenced without finding the cause.
Answer
B · Assess the patient and suction if secretions are present
3.Med-surg: neuro, endocrine & renal
Answer: B · It takes months to work; pregnant women must not handle broken tablets
Why this is the answer
Finasteride, a 5-alpha reductase inhibitor, reduces the conversion of testosterone to dihydrotestosterone and shrinks the prostate over several months. It can harm a male fetus, so pregnant women should avoid handling crushed or broken tablets.
Answer
B · It takes months to work; pregnant women must not handle broken tablets
4.Med-surg: neuro, endocrine & renal
Answer: B · Gentamicin
Why this is the answer
Aminoglycosides such as gentamicin can impair neuromuscular transmission and trigger a myasthenic crisis. Fluoroquinolones, magnesium and some other drugs carry similar warnings. The nurse checks with the prescriber before giving it.
Answer
B · Gentamicin
5.Med-surg: GI, perioperative & oncology
Answer: B · About 2–3 mm larger than the stoma all round
Why this is the answer
The aperture is cut to fit closely around the stoma, leaving a small margin of about 2–3 mm (about 1/8 inch). Too large exposes skin to output; too small can cut into the stoma. Stomas shrink during the first weeks, so measurement is repeated.
Answer
B · About 2–3 mm larger than the stoma all round
6.Med-surg: GI, perioperative & oncology
Answer: D · Opioid toxicity is likely; the oxygen may be masking hypoventilation
Why this is the answer
Supplemental oxygen can keep SpO₂ normal while CO₂ rises from hypoventilation. Increasing sedation is an early sign of opioid toxicity. The nurse stops the PCA, stimulates the patient, calls for help and follows the naloxone protocol, monitoring respiratory rate, depth and sedation closely.
Answer
D · Opioid toxicity is likely; the oxygen may be masking hypoventilation
7.Clinical nursing
Answer: D · Respiratory alkalosis from a low PaCO2
Why this is the answer
Hyperventilation blows off CO2, raising the pH. Symptoms can include tingling of the lips and fingers and lightheadedness.
Answer
D · Respiratory alkalosis from a low PaCO2
8.Clinical nursing
Answer: A · "If I forget a dose, I'll take two the next day to catch up."
Why this is the answer
Doubling up on an anticoagulant increases the bleeding risk. Patients follow the specific missed-dose advice for their drug and never take a double dose.
Answer
A · "If I forget a dose, I'll take two the next day to catch up."
9.Lab values & electrolytes
Answer: C · A low serum calcium
Why this is the answer
When failing kidneys retain phosphate, phosphate binds calcium and vitamin D activation falls, so serum calcium tends to drop. This drives secondary hyperparathyroidism and bone disease.Checked against:Hypocalcemia (StatPearls) · StatPearls (NCBI Bookshelf) (2026); Phosphate in Blood · MedlinePlus (NIH) (2023)
Answer
C · A low serum calcium
10.Lab values & electrolytes
Answer: C · Acute kidney injury, because it rose by at least 0.3 mg/dL within 48 hours
Why this is the answer
KDIGO defines AKI as a creatinine rise of at least 0.3 mg/dL (26.5 µmol/L) within 48 hours, a rise to 1.5 times baseline within 7 days, or urine output below 0.5 mL/kg/h for 6 hours. A result inside the reference range can still be a significant rise.
Answer
C · Acute kidney injury, because it rose by at least 0.3 mg/dL within 48 hours
11.Arterial blood gas interpretation
Answer: Osm = 330 mOsm/kg
Derived values: calculated serum osmolality is 2·Na⁺ + glucose + urea with all values in mmol/L (2·Na⁺ + glucose/18 + BUN/2.8 with glucose and BUN in mg/dL); normal is about 275–295 mOsm/kg. The P/F ratio is PaO₂ divided by FiO₂ as a fraction. The alveolar oxygen pressure is PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 mmHg at sea level, and the A–a gradient is PAO₂ − PaO₂.
Calculated osmolality
Osm = 2·145 + 15.6 + 24.5 = 330.1 ≈ 330 mOsm/kg
Answer
Osm = 330 mOsm/kg
12.Arterial blood gas interpretation
Answer: added respiratory acidosis
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Expected PaCO₂
1.5·8 + 8 = 20 → 18–22 mmHg
Compare
measured: 26 mmHg → added respiratory acidosis
Answer
added respiratory acidosis
13.ECG rhythm strip interpretation
Answer: ventricular bigeminy
Rhythm criteria (lead II): sinus rhythm has an upright P wave before every QRS, a constant PR of 0.12–0.20 s and a narrow QRS: normal sinus rhythm at 60–100/min, sinus bradycardia below 60, sinus tachycardia above 100. Atrial fibrillation: no P waves, a fibrillatory baseline and an irregularly irregular R–R. Atrial flutter: sawtooth flutter waves at about 250–350/min with a fixed conduction ratio such as 2:1 or 4:1. First-degree AV block: sinus rhythm with a constant PR above 0.20 s. Junctional rhythm: narrow QRS at 40–60/min with absent or inverted P waves (PR below 0.12 s, or P after the QRS). A PVC is an early, wide (0.12 s or more), bizarre QRS without a P wave, with the T wave in the opposite direction and usually a full compensatory pause; in bigeminy every second beat is a PVC.
Five steps
1. Rate: 7 QRS complexes in 6 s, × 10 = 70 per minute.
2. Rhythm: regularly irregular, a short and a long R–R alternate (0.42 s and 1.18 s).
3. P waves: upright before every narrow QRS; none before the early wide beats.
4. PR interval: 0.14 s, constant, within 0.12–0.20 s.
5. QRS: 0.08 s in the sinus beats; the early beats are wide (0.14 s) and bizarre, with the T wave pointing the other way.
Interpretation
ventricular bigeminy
Answer
ventricular bigeminy
14.ECG rhythm strip interpretation
Answer: dual-chamber (AV) paced rhythm
Paced rhythms: a pacemaker impulse shows as a narrow vertical pacing spike. After a ventricular spike the QRS is wide (0.12 s or more), because the impulse spreads from the lead through the muscle instead of the conduction system; with right-ventricular pacing it is often mostly negative in lead II. A spike before each P wave means atrial pacing, and a dual-chamber (AV) pacemaker shows an atrial spike and a P wave, then, after the programmed AV delay, a ventricular spike and a wide QRS. Capture means every spike is followed by a depolarisation. Failure to capture is a spike without a P wave or QRS after it; failure to sense (spikes that ignore the patient’s own beats) and failure to pace (no spike when one is due) are the other classic malfunctions.
Five steps
1. Rate: R–R = 21 small boxes, 1500 ÷ 21 ≈ 71 per minute.
2. Rhythm: regular, every R–R is 0.84 s.
3. P waves: each P wave follows its own pacing spike (atrial pacing).
4. AV interval: the second spike comes 0.16 s after the first one (the programmed AV delay).
5. QRS: 0.14 s, wide, right after the second spike (ventricular pacing).
Interpretation
dual-chamber (AV) paced rhythm
Answer
dual-chamber (AV) paced rhythm
The paced QRS is wide by nature; do not call it a bundle branch block or a ventricular rhythm.
15.Prioritization & delegation
Answer: D · Raise the head of the bed, give oxygen and call for urgent help
Why this is the answer
Sudden breathlessness and chest pain after surgery suggest a pulmonary embolism. The nurse supports breathing with positioning and oxygen and escalates at once; walking or leg massage could make things worse.
Answer
D · Raise the head of the bed, give oxygen and call for urgent help
16.Prioritization & delegation
Answer: C · Morning vital signs on the four stable patients
Why this is the answer
Routine vital signs on stable patients can be delegated, freeing the RN to assess and treat the unstable patient. Assessment, IV medication and explaining a new diagnosis stay with the RN.
Answer
C · Morning vital signs on the four stable patients