Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
After thrombolysis for a myocardial infarction, which complication is the nurse most concerned to detect?
AConstipation from bed rest
BA high blood glucose caused by the thrombolytic drug itself
CBleeding, including a sudden change in neurological status
DA skin rash appearing at the sites of the ECG electrodes
2.Med-surg: cardiovascular & respiratoryHard
A 70-year-old man has a small abdominal aortic aneurysm found on screening and is placed under surveillance. Which advice is most important?
AAvoid all exercise and lifting for the rest of his life to protect the aorta
BHave the aneurysm repaired immediately, whatever its size or growth rate
CStop all blood pressure medicines to avoid low pressure
DStop smoking, control BP and seek help at once for sudden back pain
3.Med-surg: neuro, endocrine & renalMedium
Which statement about giving IV phenytoin is correct?
AIt needs no monitoring of the heart rhythm or blood pressure
BIt is given in 0.9% sodium chloride with cardiac monitoring
CIt should be pushed rapidly over a few seconds
DIt can be mixed into any glucose infusion
4.Med-surg: neuro, endocrine & renalHard
A nurse teaches a carer to give buccal midazolam for prolonged seizures. Which statement shows a need for further teaching?
A"I will write down the time the seizure started and the time I gave the dose."
B"I will call an ambulance if the care plan tells me to."
C"I will put something between his teeth so he does not bite his tongue."
D"I will give it into the space between his gum and cheek."
5.Med-surg: GI, perioperative & oncologyMedium
Which monitoring is especially important for a patient receiving parenteral nutrition?
APupil size and limb strength
BBowel sounds and stool colour only
CPeak flow and visual acuity
DBlood glucose and signs of line infection
6.Med-surg: GI, perioperative & oncologyHard
A nurse spills a small amount of a cytotoxic drug on the floor. What is the correct approach?
AWipe it with a paper towel and put it in the general waste bin
BMop it up with the ward mop and rinse the mop in the sluice
CLeave it to evaporate and keep people away for a few minutes
DUse the spill kit with PPE, clean up, bag as cytotoxic waste and report
7.Clinical nursingMedium
The WHO analgesic ladder recommends:
AUsing only non-drug methods for cancer pain
BMoving from non-opioids to weak and then strong opioids as pain increases
CGiving analgesia only when pain becomes severe
DStarting all patients on strong opioids
8.Clinical nursingHard
Soon after starting chemotherapy for a high-grade lymphoma, a patient has rising potassium, phosphate and uric acid with falling urine output. What is the most likely cause?
ATumour lysis syndrome
BRefeeding syndrome
CAdrenal insufficiency
DSyndrome of inappropriate ADH secretion
9.Lab values & electrolytesMedium
In the US, when is a pregnant woman without known risk factors usually screened for gestational diabetes?
AAt about 38–40 weeks of pregnancy
BAt about 6–8 weeks of pregnancy
COnly after the baby is born
DAt about 24–28 weeks of pregnancy
10.Lab values & electrolytesHard
A patient with diabetic ketoacidosis is receiving an IV insulin infusion. Which laboratory value must be monitored especially closely?
AAlbumin, because insulin makes the liver stop producing it
BHemoglobin, because insulin breaks down red blood cells
CSodium, because insulin causes the kidneys to excrete very large amounts of it
DPotassium, because insulin moves it into the cells and it can fall quickly
11.Arterial blood gas interpretationMedium
A practice arterial blood gas shows pH 7.42, PaCO₂ 54 mmHg (7.2 kPa) and HCO₃⁻ 34 mmol/L. The primary disorder is metabolic alkalosis. How far is it compensated? Click your answer.
pH 7.42PaCO₂ 54 mmHg (7.2 kPa)HCO₃⁻ 34 mmol/L
1uncompensated
2partially compensated
3fully compensated
12.Arterial blood gas interpretationHard
A practice gas shows pH 7.26, PaCO₂ 23 mmHg (3.1 kPa) and HCO₃⁻ 10 mmol/L, with Na⁺ 138 and Cl⁻ 109 mmol/L. Use the anion gap and the delta ratio to click the best interpretation.
This lead II strip shows sinus rhythm with one pause. Measure the pause, the R–R interval across it, in seconds.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
pause = s
14.ECG rhythm strip interpretationHard
Identify the rhythm on this lead II strip. Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1sinus bradycardia
2ventricular fibrillation
3asystole
4third-degree (complete) AV block
15.Prioritization & delegationMedium
A patient receiving chemotherapy has a temperature of 38.3 °C and a very low neutrophil count. What should the nurse do?
AReport it at once, because cultures and antibiotics are needed quickly
BGive a cool shower and offer extra fluids, then wait and see what happens
CRecheck the temperature in four hours before telling anyone
DDocument the reading and mention it at the next handover
16.Prioritization & delegationHard
A 2-month-old infant has a spiral fracture of the femur. The parents say the baby rolled off the sofa. What should the nurse recognize?
ANo further action is needed once the fracture is treated
BThe injury does not fit the infant’s development, so possible abuse must be reported
CA spiral fracture in an infant is always caused by birth trauma
DInfants of this age often roll off furniture and break bones in this way
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: C · Bleeding, including a sudden change in neurological status
Why this is the answer
The main risk of thrombolysis is bleeding, from puncture sites, gums or the gut, and most seriously intracranial haemorrhage. The nurse monitors puncture sites, vital signs and neurological status and minimises invasive procedures. Reperfusion arrhythmias are also common.
Answer
C · Bleeding, including a sudden change in neurological status
2.Med-surg: cardiovascular & respiratory
Answer: D · Stop smoking, control BP and seek help at once for sudden back pain
Why this is the answer
Small aneurysms are usually monitored with regular ultrasound, with repair considered when they reach a threshold size or grow fast. Stopping smoking slows growth, and BP and cardiovascular risk are managed. Sudden abdominal or back pain may mean rupture and needs emergency care.
Answer
D · Stop smoking, control BP and seek help at once for sudden back pain
3.Med-surg: neuro, endocrine & renal
Answer: B · It is given in 0.9% sodium chloride with cardiac monitoring
Why this is the answer
Phenytoin precipitates in glucose-containing solutions and is given in 0.9% sodium chloride, usually through an in-line filter. Infusing too fast can cause hypotension, bradycardia and arrhythmias, so the rate is limited and ECG and blood pressure are monitored.
Answer
B · It is given in 0.9% sodium chloride with cardiac monitoring
4.Med-surg: neuro, endocrine & renal
Answer: C · "I will put something between his teeth so he does not bite his tongue."
Why this is the answer
Nothing should ever be put between the teeth during a seizure. Buccal midazolam is given between the gum and cheek, so the mouth does not need to be forced open. Timing the seizure and following the emergency care plan are correct.
Answer
C · "I will put something between his teeth so he does not bite his tongue."
5.Med-surg: GI, perioperative & oncology
Answer: D · Blood glucose and signs of line infection
Why this is the answer
PN can cause hyperglycaemia and electrolyte disturbance, and the central line is a route for bloodstream infection. Glucose, electrolytes, fluid balance, weight and temperature are monitored closely.
Answer
D · Blood glucose and signs of line infection
6.Med-surg: GI, perioperative & oncology
Answer: D · Use the spill kit with PPE, clean up, bag as cytotoxic waste and report
Why this is the answer
Cytotoxic spills are managed using a dedicated spill kit with gloves, gown, eye protection and a mask as needed. The spill is contained, absorbed and cleaned from the outside in, waste is placed in labelled cytotoxic waste and the incident is reported.
Answer
D · Use the spill kit with PPE, clean up, bag as cytotoxic waste and report
7.Clinical nursing
Answer: B · Moving from non-opioids to weak and then strong opioids as pain increases
Why this is the answer
The ladder moves from non-opioids (such as paracetamol) to weak opioids and then strong opioids, with adjuvants at any step. Regular dosing is preferred for persistent pain.
Answer
B · Moving from non-opioids to weak and then strong opioids as pain increases
8.Clinical nursing
Answer: A · Tumour lysis syndrome
Why this is the answer
Rapid tumour cell death releases potassium, phosphate and nucleic acids (forming uric acid), which can cause AKI and arrhythmias. Prevention includes IV hydration and drugs to lower uric acid.
Answer
A · Tumour lysis syndrome
9.Lab values & electrolytes
Answer: D · At about 24–28 weeks of pregnancy
Why this is the answer
Placental hormones increase insulin resistance in the second half of pregnancy, so US guidance recommends screening all women at 24–28 weeks, with earlier testing for those with risk factors. In the UK, NICE recommends an oral glucose tolerance test at 24–28 weeks only for women with risk factors.Checked against:Glucose screening tests during pregnancy · MedlinePlus (NIH) (2026); Gestational diabetes · MedlinePlus (NIH) (2026)
Answer
D · At about 24–28 weeks of pregnancy
10.Lab values & electrolytes
Answer: D · Potassium, because insulin moves it into the cells and it can fall quickly
Why this is the answer
In DKA the body has lost potassium in the urine, but the serum level may be normal or high because acidosis and lack of insulin shift potassium out of cells. Insulin drives it back in, so the level can fall fast. Potassium is checked often and replaced as prescribed.
Answer
D · Potassium, because insulin moves it into the cells and it can fall quickly
11.Arterial blood gas interpretation
Answer: fully compensated
Reading a blood gas (ROME): first the pH: below 7.35 is acidaemia, above 7.45 alkalaemia. Then find the value that explains it. PaCO₂ (normal 35–45 mmHg, 4.7–6.0 kPa) is the respiratory part and moves Opposite to the pH in a respiratory disorder; HCO₃⁻ (normal 22–26 mmol/L) is the metabolic part and moves in the same direction as the pH (Respiratory Opposite, Metabolic Equal). The other value shows the compensation: normal means uncompensated; abnormal in the direction that pulls the pH back while the pH is still abnormal means partially compensated; a normal pH with both values abnormal means fully compensated. Ranges differ slightly between laboratories; these are practice values.
ROME, value by value
pH 7.42: within 7.35–7.45
PaCO₂ 54 mmHg: high (35–45)
HCO₃⁻ 34 mmol/L: high (22–26)
Compensation
Clinically, also check the expected compensation: for a metabolic alkalosis PaCO₂ ≈ 0.7·HCO₃⁻ + 21 = 42.8–46.8 mmHg, so the measured 54 mmHg points to an additional respiratory acidosis (a mixed disorder). The answer above is the ROME exam classification.
fully compensated
Answer
fully compensated
12.Arterial blood gas interpretation
Answer: added normal-gap acidosis
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Anion gap
AG = 138 − (109 + 10) = 19
Delta ratio
(19 − 12)/(24 − 10) = 0.5
added normal-gap acidosis
Answer
added normal-gap acidosis
13.ECG rhythm strip interpretation
Answer: pause = 2.12 s
Narrow-complex tachycardia and pauses: supraventricular tachycardia (SVT) is a regular tachycardia at about 150–250/min with narrow QRS complexes; the P waves are usually not visible because they are hidden in the QRS complex or the T wave. Sinus tachycardia in an adult at rest is usually below about 150/min and has a visible P wave before every QRS; atrial flutter with 2:1 conduction often runs at about 150/min and shows sawtooth waves. In sinus arrest the sinus node stops firing for a moment: a pause with no P wave and no QRS whose length is not a whole number of P–P cycles (a pause of exactly two or three cycles points to sinus exit block instead).
Measure
53 small boxes from R to R across the pause
Convert
pause = 53 × 0.04 s = 2.12 s
Compare with P–P
2.12 ÷ 0.92 ≈ 2.3 P–P cycles, not a whole number
Answer
pause = 2.12 s
No P wave appears in the pause, and the pause is not a whole number of P–P cycles: sinus arrest. A pause of exactly two or three cycles would point to sinus exit block.
14.ECG rhythm strip interpretation
Answer: asystole
Ventricular rhythms: ventricular tachycardia is a run of three or more wide (0.12 s or more) complexes in a row at more than 100/min, usually 150–250/min, regular, without related P waves. Ventricular fibrillation is a chaotic, irregular waveform with no identifiable P waves, QRS complexes or T waves and no countable rate. Asystole is an almost flat line with no ventricular activity; a flat line is always confirmed by checking the patient, the leads and the gain and a second lead. In resuscitation guidelines VF and pulseless VT are the shockable rhythms and asystole is not.
Five steps
1. Rate: no countable ventricular rate.
2. Rhythm: none; an almost flat line.
3. P waves: none identifiable.
4. PR interval: not measurable.
5. QRS: no QRS complexes.
Interpretation
asystole
Answer
asystole
A flat line is always checked: look at the patient, the leads and the gain, and view a second lead, because a loose electrode or fine VF can look like asystole.
15.Prioritization & delegation
Answer: A · Report it at once, because cultures and antibiotics are needed quickly
Why this is the answer
Neutropenic fever is a medical emergency. The patient may have few other signs of infection, so the nurse reports it immediately so that cultures can be taken and IV antibiotics started.
Answer
A · Report it at once, because cultures and antibiotics are needed quickly
16.Prioritization & delegation
Answer: B · The injury does not fit the infant’s development, so possible abuse must be reported
Why this is the answer
Most 2-month-olds cannot roll, and a spiral fracture in a non-mobile infant suggests a twisting force. Nurses must report suspected abuse according to law and policy.
Answer
B · The injury does not fit the infant’s development, so possible abuse must be reported