Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
A patient's blood pressure is 120/60 mmHg. What is the approximate mean arterial pressure?
A100 mmHg
B60 mmHg
C90 mmHg
D80 mmHg
2.Med-surg: cardiovascular & respiratoryHard
A patient being treated for pulmonary TB repeatedly misses doses and stops when they feel better. Which strategy is most effective?
ADirectly observed therapy with support for barriers to adherence
BStopping treatment, as it is clearly not working for this patient
CDoubling the dose on the days the patient remembers to take it
DSwitching to a single drug to make it easier
3.Med-surg: neuro, endocrine & renalMedium
What is the dexamethasone suppression test used for?
ATo check thyroid function
BTo measure kidney function
CTo diagnose diabetes insipidus
DTo help diagnose Cushing's syndrome
4.Med-surg: neuro, endocrine & renalHard
A patient's glucose is 6.2 mmol/L (112 mg/dL) at 03:00 and 12 mmol/L (216 mg/dL) before breakfast. No hypoglycaemia occurred overnight. What is the most likely explanation?
AThe Somogyi effect from a night-time hypo
BThe meter is faulty and should be replaced
CA large snack eaten in the night by mistake
DThe dawn phenomenon from early-morning hormones
5.Med-surg: GI, perioperative & oncologyMedium
What are anticipatory ("just in case") medicines at the end of life usually prescribed for?
AWeight gain and appetite stimulation
BInfection prevention and vaccination
CHigh blood pressure, high cholesterol and diabetes
DPain, nausea, agitation and respiratory secretions
6.Med-surg: GI, perioperative & oncologyHard
During a nerve block, a patient reports a metallic taste and ringing in the ears, then has a seizure. Besides calling for help and supporting the airway, which specific treatment is given?
AIV dantrolene
BIV glucose 50%
CIV lipid emulsion
DIV naloxone
7.Clinical nursingMedium
A dying patient can no longer drink and has a dry mouth. What is the most appropriate nursing care?
ALeaving the mouth alone to avoid disturbing them
BStarting a fast intravenous infusion to correct the dryness
CFrequent mouth care that keeps the lips and mouth moist
DInserting a nasogastric tube for fluids
8.Clinical nursingHard
A day after surgery, a patient's haemoglobin has fallen from 125 g/L to 85 g/L (12.5 to 8.5 g/dL) and their heart rate has risen to 118/min. What is the priority?
ARecheck the haemoglobin next week
BEscalate urgently, as the patient may be bleeding
CEncourage the patient to eat iron-rich foods
DDocument the result and take no further action
9.Lab values & electrolytesMedium
A patient is on an IV insulin infusion protocol in the ICU. How often is the blood glucose usually checked?
AOnly if symptoms occur
BOnce a day before breakfast
CAbout every hour
DOnce every 12 hours
10.Lab values & electrolytesHard
A patient in DKA is receiving IV fluids and insulin. The glucose has fallen to about 220 mg/dL (12.2 mmol/L), but the anion gap is still high. What change would the nurse expect?
AStop the insulin infusion because the glucose is near normal
BAdd dextrose to the IV fluids and continue the insulin
CGive an IV bolus of sodium bicarbonate at once
DStop the IV fluids and start oral fluids only
11.Arterial blood gas interpretationMedium
A practice arterial blood gas shows pH 7.56, PaCO₂ 42 mmHg (5.6 kPa) and HCO₃⁻ 36 mmol/L. The primary disorder is metabolic alkalosis. How far is it compensated? Click your answer.
pH 7.56PaCO₂ 42 mmHg (5.6 kPa)HCO₃⁻ 36 mmol/L
1uncompensated
2partially compensated
3fully compensated
12.Arterial blood gas interpretationHard
A practice gas shows a metabolic alkalosis with HCO₃⁻ 35 mmol/L. Use expected PaCO₂ = 0.7·HCO₃⁻ + 21 to find the expected PaCO₂.
HCO₃⁻ 35 mmol/L
PaCO₂ = mmHg
13.ECG rhythm strip interpretationMedium
Measure the QT interval and the R–R interval on this regular lead II strip, then calculate the rate-corrected QTc with Bazett’s formula QTc = QT/√RR (both in seconds). Give the answer in seconds to three decimals.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
QTc = s
14.ECG rhythm strip interpretationHard
This lead II strip shows a conduction problem between the atria and the ventricles. Which rhythm is it? Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1atrial fibrillation
2second-degree AV block type II
3second-degree AV block type I (Wenckebach)
4third-degree (complete) AV block
15.Prioritization & delegationMedium
A patient taking lithium has vomiting, diarrhea and a new coarse tremor. What should the nurse do?
AReassure the patient that a coarse tremor is expected at first
BEncourage the patient to cut down on salt and fluids
CHold the next dose and report for an urgent lithium level
DGive the dose with food to reduce the stomach upset
16.Prioritization & delegationHard
Which patient’s finding is the most urgent?
AA patient whose platelet count result is pending
BA patient on warfarin with an INR of 2.5 who is due for the usual evening dose
CA patient on a heparin infusion who has new confusion and a severe headache
DA patient after knee surgery with a small bruise at an injection site
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: D · 80 mmHg
Why this is the answer
MAP ≈ diastolic + (systolic − diastolic) ÷ 3 = 60 + 60 ÷ 3 = 80 mmHg. The heart spends longer in diastole, so MAP is closer to the diastolic value. A MAP of at least about 65 mmHg is a common target for organ perfusion.
Answer
D · 80 mmHg
2.Med-surg: cardiovascular & respiratory
Answer: A · Directly observed therapy with support for barriers to adherence
Why this is the answer
Directly observed therapy, where a health worker watches each dose, plus help with practical and social barriers, improves completion and reduces multidrug-resistant TB. Single-drug therapy or interrupted treatment breeds resistance.
Answer
A · Directly observed therapy with support for barriers to adherence
3.Med-surg: neuro, endocrine & renal
Answer: D · To help diagnose Cushing's syndrome
Why this is the answer
A dose of dexamethasone normally suppresses ACTH and cortisol. In Cushing's syndrome, cortisol stays high. The test is part of the work-up for cortisol excess.
Answer
D · To help diagnose Cushing's syndrome
4.Med-surg: neuro, endocrine & renal
Answer: D · The dawn phenomenon from early-morning hormones
Why this is the answer
In the dawn phenomenon, cortisol and growth hormone rise in the early morning and push glucose up without a preceding hypo. A night-time hypo followed by rebound hyperglycaemia would suggest the Somogyi effect. The prescriber can adjust the insulin regimen.
Answer
D · The dawn phenomenon from early-morning hormones
5.Med-surg: GI, perioperative & oncology
Answer: D · Pain, nausea, agitation and respiratory secretions
Why this is the answer
Anticipatory medicines are prescribed in advance, usually for subcutaneous use, so that common end-of-life symptoms can be treated quickly without delay, especially at home.
Answer
D · Pain, nausea, agitation and respiratory secretions
6.Med-surg: GI, perioperative & oncology
Answer: C · IV lipid emulsion
Why this is the answer
These are signs of local anaesthetic systemic toxicity. The injection is stopped, help is called, the airway is secured and seizures are treated. IV lipid emulsion is the specific treatment, especially if the circulation is affected.
Answer
C · IV lipid emulsion
7.Clinical nursing
Answer: C · Frequent mouth care that keeps the lips and mouth moist
Why this is the answer
Regular mouth care with moist swabs, water sprays and lip balm relieves a dry mouth in the last days of life. Families can be shown how to help.
Answer
C · Frequent mouth care that keeps the lips and mouth moist
8.Clinical nursing
Answer: B · Escalate urgently, as the patient may be bleeding
Why this is the answer
A large fall in haemoglobin with tachycardia suggests ongoing blood loss. The nurse assesses the patient with ABCDE, checks wounds and drains and escalates for urgent review.
Answer
B · Escalate urgently, as the patient may be bleeding
9.Lab values & electrolytes
Answer: C · About every hour
Why this is the answer
IV insulin acts quickly and has a short half-life, so glucose is usually checked hourly (or as the protocol specifies) and the rate adjusted. This reduces the risk of hypoglycemia and keeps glucose in the target range.
Answer
C · About every hour
10.Lab values & electrolytes
Answer: B · Add dextrose to the IV fluids and continue the insulin
Why this is the answer
The glucose usually falls before the ketoacidosis resolves. Dextrose is added so insulin can continue, clearing ketones without causing hypoglycemia, until the anion gap closes. Stopping insulin too early lets ketoacidosis return.
Answer
B · Add dextrose to the IV fluids and continue the insulin
11.Arterial blood gas interpretation
Answer: uncompensated
Reading a blood gas (ROME): first the pH: below 7.35 is acidaemia, above 7.45 alkalaemia. Then find the value that explains it. PaCO₂ (normal 35–45 mmHg, 4.7–6.0 kPa) is the respiratory part and moves Opposite to the pH in a respiratory disorder; HCO₃⁻ (normal 22–26 mmol/L) is the metabolic part and moves in the same direction as the pH (Respiratory Opposite, Metabolic Equal). The other value shows the compensation: normal means uncompensated; abnormal in the direction that pulls the pH back while the pH is still abnormal means partially compensated; a normal pH with both values abnormal means fully compensated. Ranges differ slightly between laboratories; these are practice values.
ROME, value by value
pH 7.56: alkalaemia (above 7.45)
PaCO₂ 42 mmHg: normal (35–45)
HCO₃⁻ 36 mmol/L: high (22–26)
Compensation
Clinically, also check the expected compensation: for a metabolic alkalosis PaCO₂ ≈ 0.7·HCO₃⁻ + 21 = 44.2–48.2 mmHg, so the measured 42 mmHg points to an additional respiratory alkalosis (a mixed disorder). The answer above is the ROME exam classification.
uncompensated
Answer
uncompensated
12.Arterial blood gas interpretation
Answer: PaCO₂ = 45.5 mmHg
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Expected PaCO₂
0.7·35 + 21 = 45.5 mmHg
Answer
PaCO₂ = 45.5 mmHg
The rise has a limit: PaCO₂ rarely goes above about 55 mmHg from compensation alone.
13.ECG rhythm strip interpretation
Answer: QTc = 0.509 s
QT and QTc: the QT interval runs from the start of the QRS complex to the end of the T wave. It shortens as the heart rate rises, so it is corrected for rate with the R–R interval in seconds: Bazett QTc = QT/√RR and Fridericia QTc = QT/∛RR. Bazett is the formula most textbooks use; it over-corrects at fast rates, where Fridericia is preferred. Limits differ between references: a QTc above about 0.45 s in men or 0.46 s in women is usually called prolonged, and above 0.50 s markedly prolonged.
Measure
QT = 10.5 × 0.04 = 0.42 s
RR = 17 × 0.04 = 0.68 s
Bazett’s formula
QTc = 0.42/√0.68 = 0.42/0.8246 = 0.509 s
Answer
QTc = 0.509 s
Above 0.50 s: markedly prolonged. (509 ms)
14.ECG rhythm strip interpretation
Answer: second-degree AV block type I (Wenckebach)
AV blocks: march out the P waves and check which ones are followed by a QRS. First-degree: every P conducted, PR constant and above 0.20 s. Second-degree type I (Mobitz I, Wenckebach): the PR lengthens from beat to beat until one P wave is not conducted, then the cycle starts again (group beating). Second-degree type II (Mobitz II): the PR of the conducted beats stays constant, and P waves are suddenly not conducted; the QRS is often wide. Third-degree (complete) block: P waves and QRS complexes are each regular but independent, the PR varies at random and the atrial rate is faster than the escape rate (junctional 40–60/min with a narrow QRS, ventricular 20–40/min with a wide QRS). A 2:1 block cannot be called type I or type II from one strip.
Five steps
1. Rate: 4 QRS complexes in 6 s, × 10 = 40 per minute.
2. Rhythm: regularly irregular, the QRS complexes come in groups separated by a pause (group beating).
3. P waves: upright and regular (P–P 1.00 s, 60 per minute); one P in every 4 is not followed by a QRS.
4. PR interval: lengthens 0.16 → 0.30 → 0.38 s, then a P wave is not conducted.
5. QRS: 0.10 s, narrow (below 0.12 s).
Interpretation
second-degree AV block type I (Wenckebach)
Answer
second-degree AV block type I (Wenckebach)
15.Prioritization & delegation
Answer: C · Hold the next dose and report for an urgent lithium level
Why this is the answer
Vomiting, diarrhea and a coarse tremor suggest lithium toxicity. The nurse holds the dose and reports so a serum level can be checked; low salt or fluid intake raises lithium levels further.
Answer
C · Hold the next dose and report for an urgent lithium level
16.Prioritization & delegation
Answer: C · A patient on a heparin infusion who has new confusion and a severe headache
Why this is the answer
New confusion and a severe headache in an anticoagulated patient may mean an intracranial bleed. An INR of 2.5 is within the common therapeutic range of 2 to 3, and a small injection-site bruise is common.
Answer
C · A patient on a heparin infusion who has new confusion and a severe headache