Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
A patient with heart failure starts dapagliflozin, an SGLT2 inhibitor. Which teaching is most relevant?
AExpect the urine to turn bright orange and stain underwear and clothes
BAvoid drinking any fluids at all for the first week of treatment
CKeep the genital area clean, as fungal infections are more common
DTake an extra dose if the ankles swell
2.Med-surg: cardiovascular & respiratoryHard
A patient's chest drain tubing disconnects from the drainage unit. What should the nurse do first?
ALeave it open to air until the doctor arrives to review it
BReconnect it, or put the tube end in sterile water, then assess
CClamp the tube for several hours and recheck the patient later
DRemove the drain from the chest and cover the site
3.Med-surg: neuro, endocrine & renalMedium
Why does a patient with untreated hypothyroidism need extra care when given opioids or sedatives?
AThere is no difference compared with other patients
BThey clear the drugs too fast, so higher doses are needed
CThey break the drugs down slowly and are more sensitive to them
DThese drugs make the thyroid gland overactive
4.Med-surg: neuro, endocrine & renalHard
A patient's glucose is 6.2 mmol/L (112 mg/dL) at 03:00 and 12 mmol/L (216 mg/dL) before breakfast. No hypoglycaemia occurred overnight. What is the most likely explanation?
AThe Somogyi effect from a night-time hypo
BThe meter is faulty and should be replaced
CThe dawn phenomenon from early-morning hormones
DA large snack eaten in the night by mistake
5.Med-surg: GI, perioperative & oncologyMedium
Which wound drain observation should be reported immediately?
ADrainage slowly falling each day
BSmall amounts of pink serous fluid
CA sudden large volume of fresh red blood
DA little dried blood around the drain site
6.Med-surg: GI, perioperative & oncologyHard
A patient with facial burns from a house fire was talking normally on arrival. Two hours later, the voice is hoarse and there is stridor. What should the nurse do?
ACall for urgent anaesthetic help, as the airway is swelling
BGive a warm drink to soothe the throat
CEncourage the patient to rest the voice and reassess tomorrow
DLay the patient flat to help them sleep
7.Clinical nursingMedium
Why is blood pressure monitored closely in a patient with an epidural infusion?
AThe local anaesthetic can block sympathetic nerves and cause hypotension
BThe epidural pump uses the blood pressure to set the rate
CEpidurals always cause severe hypertension that needs regular treatment
DBlood pressure readings show whether the catheter is infected
8.Clinical nursingHard
A patient with lung cancer develops swelling of the face and arms, distended neck veins and breathlessness that is worse lying down. What should be suspected?
AHypothyroidism
BAn allergic reaction to food
CRight-sided heart failure from valve disease
DSuperior vena cava obstruction
9.Lab values & electrolytesMedium
A healthy patient's result is slightly outside the laboratory reference range, and all other results are normal. Which statement best explains why this can happen?
AReference ranges include every healthy person without exception
BAny result outside the range always means disease is present
CReference ranges are the same in every laboratory worldwide
DRanges cover about 95% of healthy people, so some fall outside
10.Lab values & electrolytesHard
A patient recovering from acute tubular necrosis now passes 4–5 L of urine a day. Which electrolyte changes should the nurse watch for?
ANo changes, because the kidneys are now normal
BLow potassium and low sodium from urine losses
CHigh potassium and high sodium from retention
DHigh calcium and high phosphate from bone loss
11.Arterial blood gas interpretationMedium
A practice gas shows a metabolic acidosis with HCO₃⁻ 18 mmol/L. Use Winter’s formula to find the expected PaCO₂ (the centre of the range) in mmHg.
HCO₃⁻ 18 mmol/L
PaCO₂ = mmHg
12.Arterial blood gas interpretationHard
A practice gas shows a metabolic acidosis: pH 7.10, PaCO₂ 40 mmHg (5.3 kPa), HCO₃⁻ 12 mmol/L. Compare the measured PaCO₂ with Winter’s formula. Click your interpretation.
pH 7.10PaCO₂ 40 mmHg (5.3 kPa)HCO₃⁻ 12 mmol/L
1appropriate compensation
2added respiratory acidosis
3added respiratory alkalosis
13.ECG rhythm strip interpretationMedium
This lead II strip shows sinus rhythm with one pause. Measure the pause, the R–R interval across it, in seconds.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
pause = s
14.ECG rhythm strip interpretationHard
Identify the rhythm on this lead II strip. Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1asystole
2junctional rhythm
3ventricular fibrillation
4sinus bradycardia
15.Prioritization & delegationMedium
Which action helps prevent a catheter-associated urinary tract infection?
ADisconnecting the bag every shift to empty it
BKeeping the drainage bag below the level of the bladder
CLeaving the catheter in place longer than needed
DRaising the drainage bag above the bladder when walking
16.Prioritization & delegationHard
An RN sees an LPN/LVN crushing an extended-release metoprolol tablet to mix with applesauce. What should the RN do?
AReport the LPN/LVN at the end of the month without saying anything now
BLet the LPN/LVN continue, since crushing makes the tablet easier to swallow
CTell the LPN/LVN to give half of the crushed tablet now and the other half at lunchtime
DStop the LPN/LVN and contact the prescriber or pharmacist about another form
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: C · Keep the genital area clean, as fungal infections are more common
Why this is the answer
SGLT2 inhibitors increase glucose loss in the urine, raising the risk of genital thrush and urinary infections. They also cause mild diuresis, and in people with diabetes there is a rare risk of ketoacidosis, so they are paused during acute illness as advised. They improve outcomes in heart failure.
Answer
C · Keep the genital area clean, as fungal infections are more common
2.Med-surg: cardiovascular & respiratory
Answer: B · Reconnect it, or put the tube end in sterile water, then assess
Why this is the answer
A disconnected tube lets atmospheric air enter the pleural space. Reconnecting quickly, or submerging the tube end 2–3 cm in sterile water as a temporary seal, restores the one-way valve. Then assess for respiratory distress and inform the team. Prolonged clamping risks tension pneumothorax.
Answer
B · Reconnect it, or put the tube end in sterile water, then assess
3.Med-surg: neuro, endocrine & renal
Answer: C · They break the drugs down slowly and are more sensitive to them
Why this is the answer
In hypothyroidism, drug metabolism is slowed, and patients are more sensitive to sedatives and opioids. These drugs can cause respiratory depression and may even trigger myxoedema coma, so they are used with caution.
Answer
C · They break the drugs down slowly and are more sensitive to them
4.Med-surg: neuro, endocrine & renal
Answer: C · The dawn phenomenon from early-morning hormones
Why this is the answer
In the dawn phenomenon, cortisol and growth hormone rise in the early morning and push glucose up without a preceding hypo. A night-time hypo followed by rebound hyperglycaemia would suggest the Somogyi effect. The prescriber can adjust the insulin regimen.
Answer
C · The dawn phenomenon from early-morning hormones
5.Med-surg: GI, perioperative & oncology
Answer: C · A sudden large volume of fresh red blood
Why this is the answer
A sudden increase in bright red drainage suggests active haemorrhage. The nurse checks vital signs and informs the surgical team urgently. Gradually decreasing serosanguinous drainage is expected.
Answer
C · A sudden large volume of fresh red blood
6.Med-surg: GI, perioperative & oncology
Answer: A · Call for urgent anaesthetic help, as the airway is swelling
Why this is the answer
Progressive hoarseness and stridor after a facial or inhalation burn mean the airway is narrowing. Early intubation by an experienced anaesthetist is needed before swelling makes it impossible. The patient is sat up and given oxygen.
Answer
A · Call for urgent anaesthetic help, as the airway is swelling
7.Clinical nursing
Answer: A · The local anaesthetic can block sympathetic nerves and cause hypotension
Why this is the answer
Epidural local anaesthetic can cause vasodilation and hypotension. Nurses also monitor sedation, respiratory rate, block height, motor function and the catheter site.
Answer
A · The local anaesthetic can block sympathetic nerves and cause hypotension
8.Clinical nursing
Answer: D · Superior vena cava obstruction
Why this is the answer
Superior vena cava obstruction prevents venous drainage from the head and arms. It is an oncological emergency; patients are positioned upright and need urgent specialist treatment.
Answer
D · Superior vena cava obstruction
9.Lab values & electrolytes
Answer: D · Ranges cover about 95% of healthy people, so some fall outside
Why this is the answer
A reference range is usually the central 95% of results from a healthy population, so about 1 in 20 healthy people will have a value just outside it. The result is interpreted with the clinical picture and previous values, and repeated if needed.Checked against:How to Understand Your Lab Results · MedlinePlus (NIH) (2025)
Answer
D · Ranges cover about 95% of healthy people, so some fall outside
10.Lab values & electrolytes
Answer: B · Low potassium and low sodium from urine losses
Why this is the answer
In the diuretic phase of AKI, the recovering tubules lose large amounts of water and electrolytes, so dehydration, hypokalemia and hyponatremia can occur. Daily weights, intake and output, and frequent electrolytes guide replacement.Checked against:Acute tubular necrosis · MedlinePlus (NIH) (2025)
Answer
B · Low potassium and low sodium from urine losses
11.Arterial blood gas interpretation
Answer: PaCO₂ = 35 mmHg
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Winter’s formula
PaCO₂ = 1.5·18 + 8 = 35 mmHg
range: 33–37 mmHg
Answer
PaCO₂ = 35 mmHg
12.Arterial blood gas interpretation
Answer: added respiratory acidosis
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Expected PaCO₂
1.5·12 + 8 = 26 → 24–28 mmHg
Compare
measured: 40 mmHg → added respiratory acidosis
Answer
added respiratory acidosis
13.ECG rhythm strip interpretation
Answer: pause = 1.4 s
Narrow-complex tachycardia and pauses: supraventricular tachycardia (SVT) is a regular tachycardia at about 150–250/min with narrow QRS complexes; the P waves are usually not visible because they are hidden in the QRS complex or the T wave. Sinus tachycardia in an adult at rest is usually below about 150/min and has a visible P wave before every QRS; atrial flutter with 2:1 conduction often runs at about 150/min and shows sawtooth waves. In sinus arrest the sinus node stops firing for a moment: a pause with no P wave and no QRS whose length is not a whole number of P–P cycles (a pause of exactly two or three cycles points to sinus exit block instead).
Measure
35 small boxes from R to R across the pause
Convert
pause = 35 × 0.04 s = 1.4 s
Compare with P–P
1.40 ÷ 0.84 ≈ 1.7 P–P cycles, not a whole number
Answer
pause = 1.4 s
No P wave appears in the pause, and the pause is not a whole number of P–P cycles: sinus arrest. A pause of exactly two or three cycles would point to sinus exit block.
14.ECG rhythm strip interpretation
Answer: asystole
Ventricular rhythms: ventricular tachycardia is a run of three or more wide (0.12 s or more) complexes in a row at more than 100/min, usually 150–250/min, regular, without related P waves. Ventricular fibrillation is a chaotic, irregular waveform with no identifiable P waves, QRS complexes or T waves and no countable rate. Asystole is an almost flat line with no ventricular activity; a flat line is always confirmed by checking the patient, the leads and the gain and a second lead. In resuscitation guidelines VF and pulseless VT are the shockable rhythms and asystole is not.
Five steps
1. Rate: no countable ventricular rate.
2. Rhythm: none; an almost flat line.
3. P waves: none identifiable.
4. PR interval: not measurable.
5. QRS: no QRS complexes.
Interpretation
asystole
Answer
asystole
A flat line is always checked: look at the patient, the leads and the gain, and view a second lead, because a loose electrode or fine VF can look like asystole.
15.Prioritization & delegation
Answer: B · Keeping the drainage bag below the level of the bladder
Why this is the answer
Keeping the bag below the bladder prevents backflow, and the closed system is not broken. Catheters are removed as soon as they are no longer needed.
Answer
B · Keeping the drainage bag below the level of the bladder
16.Prioritization & delegation
Answer: D · Stop the LPN/LVN and contact the prescriber or pharmacist about another form
Why this is the answer
Crushing an extended-release tablet releases the whole dose at once and can cause toxicity, such as severe bradycardia or hypotension. The RN steps in now and arranges a suitable form.
Answer
D · Stop the LPN/LVN and contact the prescriber or pharmacist about another form